| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway. | 1986 | Biochem. Pharmacol. | pmid:3021173 |
| Okamoto M et al. | FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. | 1986 | J. Antibiot. | pmid:3082838 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| Chung KF et al. | Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3005546 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Söling HD and Fest W | Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues. | 1986 | J. Biol. Chem. | pmid:3095313 |
| Ostermann G et al. | The role of lipoproteins in the degradation of platelet-activating factor. | 1986 | Thromb. Res. | pmid:3798402 |
| Bussolino F et al. | Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. | 1986 | Acta Haematol. | pmid:3019063 |
| Wallace JL and Whittle BJ | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. | 1986 | Br. J. Pharmacol. | pmid:3096408 |
| Kawaguchi H and Yasuda H | Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3081036 |
| Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
| Godfroid JJ et al. | Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity. | 1987 | J. Med. Chem. | pmid:3572968 |
| Woodard DS et al. | The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. | 1987 | J. Biol. Chem. | pmid:3029085 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | 1987 | J. Biol. Chem. | pmid:3558407 |
| Miwa M et al. | Occurrence of an endogenous inhibitor of platelet-activating factor in rat liver. | 1987 | J. Biol. Chem. | pmid:3804997 |
| Doly M et al. | Effects of PAF-acether on electrophysiological response of isolated retina. | 1987 | Int J Tissue React | pmid:3596955 |
| Wilcox RW et al. | The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D. | 1987 | Lipids | pmid:3444369 |
| Kudo I et al. | Antitumor activity of synthetic alkylphospholipids with or without PAF activity. | 1987 | Lipids | pmid:3444379 |
| Codde JP et al. | Can the synthesis of platelet-activating factor, a potent vasodilator and pro-aggregatory agent, be altered by dietary marine oils? | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:2822306 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Di Marzo V et al. | Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2822041 |
| Lang CH et al. | Attenuation of endotoxin-induced increase in glucose metabolism by platelet-activating factor antagonist. | 1987 | Circ. Shock | pmid:3427772 |
| Korth R and Benveniste J | BN 52021 displaces [3H]paf-acether from, and inhibits its binding to intact human platelets. | 1987 | Eur. J. Pharmacol. | pmid:3428349 |
| Gomez-Cambronero J et al. | The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2823810 |
| Bertani T et al. | Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. | 1987 | Kidney Int. | pmid:3039232 |
| Doebber TW and Wu MS | Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3478712 |
| Bussolino F et al. | Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. | 1987 | Biochim. Biophys. Acta | pmid:3024738 |