Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Viremia D014766 4 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Bronchiectasis D001987 7 associated lipids
Anthrax D000881 1 associated lipids
Heart Injuries D006335 6 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Han GQ et al. [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. 1989 Yao Xue Xue Bao pmid:2609983
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Cheng NN et al. [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. 1992 Yao Xue Xue Bao pmid:1299136
Ju DW et al. [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. 1994 Yao Xue Xue Bao pmid:8042517
Zeng GQ et al. Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. 1993 Yao Xue Xue Bao pmid:8285049
Ma Y et al. [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8368081
Peng SY et al. [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. 2010 Yao Xue Xue Bao pmid:21351565
Zang BX et al. [Antagonistic effect of myricetin on platelet activing factor]. 2003 Yao Xue Xue Bao pmid:14991995
Nie ZG et al. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. 2004 Yao Xue Xue Bao pmid:15491096
Ou-Yang XY et al. [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. 2005 Yao Xue Xue Bao pmid:16011257