| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Foster AP et al. | Effects of WEB 2086, an antagonist to the receptor for platelet-activating factor (PAF), on PAF-induced responses in the horse. | 1992 | Equine Vet. J. | pmid:1318830 |
| Asako H et al. | Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. | 1992 | Gastroenterology | pmid:1319367 |
| Smither RL and Fan TP | Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. | 1992 | EXS | pmid:1319778 |
| Zeng N | [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. | 1992 | Zhonghua Yi Xue Za Zhi | pmid:1319804 |
| Sakamoto T et al. | Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. | 1992 | Eur. J. Pharmacol. | pmid:1319919 |
| Travis SP and Jewell DP | Regional differences in the response to platelet-activating factor in rabbit colon. | 1992 | Clin. Sci. | pmid:1320548 |
| Di Maria GU et al. | Nedocromil sodium inhibits the increase in airway reactivity induced by platelet activating factor in humans. | 1992 | Chest | pmid:1320563 |
| Casale TB et al. | Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1320901 |
| Mabuchi K et al. | Differential effects of platelet-activating factor on superoxide anion production in human eosinophils and neutrophils. | 1992 | Biochem. Int. | pmid:1321621 |
| Patel KD et al. | Novel leukocyte agonists are released by endothelial cells exposed to peroxide. | 1992 | J. Biol. Chem. | pmid:1321830 |
| Tufano MA et al. | Salmonella typhimurium porins stimulate platelet-activating factor synthesis by human polymorphonuclear neutrophils. | 1992 | J. Immunol. | pmid:1321849 |
| Hennet T et al. | A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. | 1992 | J. Immunol. | pmid:1321855 |
| Schwinger RH et al. | Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium. | 1992 | Am. Heart J. | pmid:1322030 |
| Seyfried CE et al. | The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. | 1992 | Genomics | pmid:1322356 |
| Heller R et al. | Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. | 1992 | Biochem. Pharmacol. | pmid:1322663 |
| Kowanko IC et al. | Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants. | 1992 | Arthritis Rheum. | pmid:1322671 |
| Gandhi CR et al. | Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. | 1992 | Biochim. Biophys. Acta | pmid:1322709 |
| Cabellos C et al. | Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae. | 1992 | J. Clin. Invest. | pmid:1322943 |
| Chau LY et al. | Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells. | 1992 | J. Neurochem. | pmid:1322966 |
| Lee TC and Snyder F | 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. | 1992 | Meth. Enzymol. | pmid:1323043 |
| Snyder F et al. | 1-alkyl-2-lyso-sn-glycero-3-phosphate acetyltransferase. | 1992 | Meth. Enzymol. | pmid:1323050 |
| Jones MA et al. | Rabbit blastocysts accumulate platelet-activating factor (PAF) and lyso-PAF in vitro. | 1992 | Mol. Reprod. Dev. | pmid:1323306 |
| Bito H et al. | Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. | 1992 | Neuron | pmid:1323312 |
| Hanahan DJ | Platelet-activating factor: a novel lipid agonist. | 1992 | Curr. Top. Cell. Regul. | pmid:1323447 |
| de Lima WT et al. | Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions. | 1992 | Eur. J. Pharmacol. | pmid:1323472 |
| Filep JG et al. | Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. | 1992 | Br. J. Pharmacol. | pmid:1324056 |
| Brodie C et al. | Ethanol inhibits ligand-activated Ca2+ channels in human B lymphocytes. | 1992 | J. Cell. Physiol. | pmid:1324242 |
| Rabinovici R et al. | Role of complement in endotoxin/platelet-activating factor-induced lung injury. | 1992 | J. Immunol. | pmid:1324280 |
| Yue TL et al. | Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells. | 1992 | Neurochem. Res. | pmid:1324441 |
| Wang S and Townley RG | Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. | 1992 | Ann Allergy | pmid:1324627 |
| Salari H et al. | Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells. | 1992 | Biochem. Cell Biol. | pmid:1324692 |
| Hiltz ME et al. | Alpha-MSH peptides inhibit acute inflammation induced in mice by rIL-1 beta, rIL-6, rTNF-alpha and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8. | 1992 | Cytokine | pmid:1325196 |
| Travers JB et al. | Binding of carbamyl-platelet-activating factor to the Raji lymphoblast platelet-activating factor receptor. | 1992 | Int. J. Immunopharmacol. | pmid:1325953 |
| Mazer BD et al. | Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. | 1992 | J. Clin. Invest. | pmid:1325997 |
| Sung CP et al. | CGRP stimulates the adhesion of leukocytes to vascular endothelial cells. | 1992 May-Jun | Peptides | pmid:1326102 |
| Agrawal DK et al. | PAF receptors and G-proteins in human blood eosinophils and neutrophils. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326343 |
| Honda Z et al. | Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326344 |
| Sugiura T et al. | Synthesis and action of PAF in human eosinophils. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326345 |
| Ikegami K et al. | Hetrazepine PAF antagonists. | 1992 Jun-Jul | J Lipid Mediat | pmid:1326346 |
| Turner NC and Wood LJ | Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1326625 |
| Jamil KM et al. | Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). | 1992 | Biochem. Biophys. Res. Commun. | pmid:1326956 |
| Nieminen MM et al. | Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man. | 1992 | Br J Clin Pharmacol | pmid:1327049 |
| Kuznetsova TI and Kulikov VI | [The effect of aldehydogenic and acyl structural analogs of platelet activating factor on the formation of superoxide radicals by human blood leukocytes]. | 1992 | Biokhimiia | pmid:1327185 |
| Herbert JM et al. | Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding. | 1992 | J Lipid Mediat | pmid:1327264 |
| Schmidt J et al. | Characterization of platelet-activating factor induced superoxide anion generation by guinea-pig alveolar macrophages. | 1992 | J Lipid Mediat | pmid:1327265 |
| Chung KF | Platelet-activating factor in inflammation and pulmonary disorders. | 1992 | Clin. Sci. | pmid:1327626 |
| Ko FN et al. | PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. | 1992 | Eur. J. Pharmacol. | pmid:1327822 |
| Liu H et al. | Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. | 1992 | J. Biol. Chem. | pmid:1328211 |
| Alvaro RF et al. | Determination of enantiomeric concentrations of a 2,5-diaryltetrahydrofuran (L-668,750), a platelet-activating factor receptor antagonist, in rat plasma using a chiral alpha 1-acid glycoprotein high-performance liquid chromatographic column. | 1992 | J. Chromatogr. | pmid:1328270 |
| Nguer CM et al. | Regulation of paf-acether receptor expression in human B cells. | 1992 | J. Immunol. | pmid:1328384 |
| Brady HR et al. | Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury. | 1992 | Kidney Int. | pmid:1328754 |
| Bensard DD et al. | Platelet activating factor alters receptor-coupled function in the isolated perfused rat heart. | 1992 | J. Surg. Res. | pmid:1328766 |
| Domingo MT et al. | Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists. | 1992 | Lipids | pmid:1328798 |
| Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
| Shukla SD et al. | Hypersensitivity of diabetic human platelets to platelet activating factor. | 1992 | Thromb. Res. | pmid:1329254 |
| Shimizu T et al. | Platelet-activating factor receptor and signal transduction. | 1992 | Biochem. Pharmacol. | pmid:1329754 |
| Rossi AG et al. | The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. | 1992 | Br. J. Pharmacol. | pmid:1330163 |
| Grigoriadis G and Stewart AG | Albumin inhibits platelet-activating factor (PAF)-induced responses in platelets and macrophages: implications for the biologically active form of PAF. | 1992 | Br. J. Pharmacol. | pmid:1330167 |
| Hiraide A et al. | Platelet-activating factor causes hypoketonaemia in starved rats. | 1992 | Clin. Sci. | pmid:1330413 |
| Nagahisa A et al. | Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist. | 1992 | Eur. J. Pharmacol. | pmid:1330589 |
| Müller S and Nigam S | Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide. | 1992 | Eur. J. Pharmacol. | pmid:1330596 |
| el-Moatassim C and Dubyak GR | A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages. | 1992 | J. Biol. Chem. | pmid:1331096 |
| Kester M et al. | Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells. | 1992 | J. Cell. Physiol. | pmid:1331121 |
| Thivierge M and Rola-Pleszczynski M | Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. | 1992 | J. Allergy Clin. Immunol. | pmid:1331218 |
| Atochina EN et al. | Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme. | 1992 | Lung | pmid:1331624 |
| Valone FH | Binding of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine to intact platelets and platelet membranes. | 1992 | Meth. Enzymol. | pmid:1331707 |
| Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
| Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
| Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
| O'Flaherty JT et al. | Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. | 1992 | Biochem. J. | pmid:1332696 |
| Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
| Cattaneo M et al. | Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. | 1992 | Blood | pmid:1333302 |
| Selak MA | Neutrophil elastase potentiates cathepsin G-induced platelet activation. | 1992 | Thromb. Haemost. | pmid:1333649 |
| Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
| Nakamura M et al. | Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. | 1992 | FEBS Lett. | pmid:1333988 |
| Bautista AP and Spitzer JJ | Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. | 1992 | Free Radic. Res. Commun. | pmid:1334036 |
| Bauldry SA et al. | Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production. | 1992 | J. Biol. Chem. | pmid:1334083 |
| Schrör K and Felsch A | Ramiprilat prevents PAF-induced myocellular and endothelial injury in a neutrophil-perfused heart preparation. | 1992 | Agents Actions Suppl. | pmid:1334351 |
| Clark GD et al. | Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | 1992 | Neuron | pmid:1334422 |
| Menegazzi R et al. | A new, one-step assay on whole cell suspensions for peroxidase secretion by human neutrophils and eosinophils. | 1992 | J. Leukoc. Biol. | pmid:1334501 |
| Bochkov VN et al. | Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins. | 1992 | Atherosclerosis | pmid:1334652 |
| Qian C et al. | Increased platelet-activating factor (PAF) concentrations in hearts and lungs of Pichinde virus-infected guinea pigs. | 1992 | J Lipid Mediat | pmid:1334721 |
| Kudolo GB and Harper MJ | Pregnancy-associated remodeling of rabbit endometrial platelet-activating factor receptors. | 1992 | J Lipid Mediat | pmid:1334722 |
| Burgers JA and Akkerman JW | Effect of platelet agonists on the binding of platelet-activating factor to human platelets. | 1992 | J Lipid Mediat | pmid:1334723 |
| Kadiri C et al. | Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF. | 1992 | Br. J. Pharmacol. | pmid:1334747 |
| Tashiro K et al. | Effects of PAF on excitatory neuro-effector transmission in dog airways. | 1992 | Br. J. Pharmacol. | pmid:1334755 |
| Tanimoto Y et al. | Effects of cytokines on human basophil chemotaxis. | 1992 | Clin. Exp. Allergy | pmid:1334781 |
| Sargeant P et al. | Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry. | 1992 | Cell Calcium | pmid:1334809 |
| Chao W et al. | Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. | 1992 | Biochem. J. | pmid:1335232 |
| Hii CS et al. | Basal and phorbol-ester-stimulated turnover of phosphatidylcholine in HeLa cells involve different pathways. | 1992 | Biochem. J. | pmid:1335237 |
| Müller S and Nigam S | Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1335246 |
| Camussi G et al. | Porins and lipopolysaccharide stimulate platelet activating factor synthesis by human mesangial cells. | 1992 | Kidney Int. | pmid:1335527 |
| Ahmed AS and Smith SK | The endometrium: prostaglandins and intracellular signalling at implantation. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1335852 |
| Wissner A et al. | Analogues of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF. | 1992 | J. Med. Chem. | pmid:1336052 |
| Hayes JP et al. | Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium. | 1992 | Eur. Respir. J. | pmid:1336735 |
| Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
| Smith IL and Smith EA | Inhibition of PAF-induced activation of human platelets by verapamil. | 1992 | Blood Coagul. Fibrinolysis | pmid:1336985 |
| Watanabe T | [Metabolism and action mechanisms of eicosanoids and platelet-activating factor in the kidney]. | 1992 | Nippon Rinsho | pmid:1337118 |
| Doucet JP and Bazan NG | Excitable membranes, lipid messengers, and immediate-early genes. Alteration of signal transduction in neuromodulation and neurotrauma. | 1992 | Mol. Neurobiol. | pmid:1337456 |
| Walker BA and Ward PA | Priming and signal transduction in neutrophils. | 1992 Sep-Oct | Biol. Signals | pmid:1339178 |