| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
| Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
| Ganbo T et al. | Platelet activating factor (PAF) effects on ciliary activity of human paranasal sinus mucosa in vitro. | 1991 | Rhinology | pmid:1947682 |
| Ganbo T et al. | Turn-over of PAF in cultures of human paranasal sinus mucosa. | 1994 | Rhinology | pmid:7839082 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Oda M et al. | [Platelet-activating factor producing cell--target cell interactions]. | 1989 | Rinsho Byori | pmid:2754814 |
| Oura Y | [The effects of platelet-activating factor (PAF) on the collagen-induced whole blood aggregation]. | 1994 | Rinsho Byori | pmid:8107285 |
| Maki N et al. | [Analysis of platelet-activating factor and its effect on the lung]. | 1993 | Rinsho Byori | pmid:8361018 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Izumi T and Shimizu T | [Biological regulation with platelet activating factor--molecular cloning and signal transduction of PAF]. | 1994 | Rinsho Ketsueki | pmid:8028185 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
| Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
| Debek W et al. | Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528982 |
| Kirejczyk JK et al. | Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528996 |
| Kirejczyk JK et al. | Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528997 |
| Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |
| Zăgrean L et al. | Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats. | 1998 Jan-Jun | Rom J Physiol | pmid:11000876 |
| Kaminker AJ and Carreras LO | [Physiopathology of thrombotic microangiopathy]. | 1989 | Sangre (Barc) | pmid:2667170 |
| Rotllan E et al. | [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. | 1993 | Sangre (Barc) | pmid:8390724 |
| Meloni Bruneri LH and Barbieri D | [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. | 1985 | Sangre (Barc) | pmid:4071355 |
| Rylander R | Role of endotoxin and glucan for the development of granulomatous disease in the lung. | 1989 | Sarcoidosis | pmid:2623374 |
| Teles de Araújo A et al. | Surfactant modifications and lipidic mediators in occupational lung diseases. | 1989 | Sarcoidosis | pmid:2623375 |
| Bottecchia D et al. | Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. | 1984 | Scand J Haematol | pmid:6695148 |
| Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
| Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
| Møller CH and Steinbrüchel DA | Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? | 2003 | Scand. Cardiovasc. J. | pmid:12881156 |
| Palmblad J et al. | Interactions between alkylglycerols and human neutrophil granulocytes. | 1990 | Scand. J. Clin. Lab. Invest. | pmid:2168089 |
| Jørgensen L et al. | Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8272758 |
| Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
| Wang LS et al. | Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. | 2002 | Scand. J. Gastroenterol. | pmid:11989839 |
| Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Binnaka T et al. | Gastric hemodynamic disturbance induced by hemorrhagic shock in rats. Role of platelet-activating factor. | 1990 | Scand. J. Gastroenterol. | pmid:2359986 |
| Gustafson C et al. | Phospholipase C from Clostridium perfringens stimulates formation and release of platelet-activating factor (PAF-acether) in cultured intestinal epithelial cells (INT 407). | 1991 | Scand. J. Gastroenterol. | pmid:1947765 |
| Kald B et al. | Phospholipase C from Clostridium perfringens stimulates acetyltransferase-dependent formation of platelet-activating factor in cultured intestinal epithelial cells (INT 407). | 1994 | Scand. J. Gastroenterol. | pmid:8209184 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
| Binnaka T et al. | Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor. | 1992 | Scand. J. Gastroenterol. | pmid:1561532 |
| Yoshida N et al. | Pathogenesis of platelet-activating factor-induced gastric mucosal damage in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2556790 |
| Rachmilewitz D et al. | Platelet-activating factor--a possible mediator in the pathogenesis of ulcerative colitis. | 1990 | Scand. J. Gastroenterol. Suppl. | pmid:1972295 |
| Kingsnorth AN | Platelet-activating factor. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8865468 |
| Iwai A et al. | Role of PAF in ischemia-reperfusion injury in the rat stomach. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595310 |
| Binnaka T et al. | Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595311 |
| Hatakeyama K et al. | Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595312 |
| Renkonen R et al. | Signal transduction during platelet-activating factor-induced lymphocyte binding to endothelial cells. | 1990 | Scand. J. Immunol. | pmid:2159182 |
| Geffner JR et al. | Interferon-gamma enhances PAF-acether production by stimulated human polymorphonuclear leucocytes. | 1991 | Scand. J. Immunol. | pmid:1903211 |
| Lindström P et al. | Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. | 1990 | Scand. J. Immunol. | pmid:1972589 |