| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Melnikova VO et al. | Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. | 2006 | J. Biol. Chem. | pmid:16306050 |
| Karagiorga G et al. | Biochemical parameters of bronchoalveolar lavage fluid in fat embolism. | 2006 | Intensive Care Med | pmid:16322975 |
| Mest HJ et al. | Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats. | 1992 | Agents Actions Suppl. | pmid:1632298 |
| Koltai M and Braquet PG | Involvement of PAF in atherogenesis. Brief review. | 1992 | Agents Actions Suppl. | pmid:1632308 |
| Löhrke B et al. | Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. | 2005 | J. Mol. Endocrinol. | pmid:16326838 |
| Appleyard CB and Hillier K | Catabolism of platelet-activating factor by human colonic mucosa. Calcium dependence of the catabolizing enzymes. | 1992 | Biochem. Pharmacol. | pmid:1632809 |
| Hollister AS et al. | Humoral factor, intraplatelet calcium, and hypertension. | 1992 | Am. J. Hypertens. | pmid:1632935 |
| Gomes MT et al. | Platelet-activating factor-like activity isolated from Trypanosoma cruzi. | 2006 | Int. J. Parasitol. | pmid:16337632 |
| Mauri P et al. | LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity. | 2006 | J Pharm Biomed Anal | pmid:16343838 |
| Bussolino F et al. | Synthesis of platelet-activating factor by polymorphonuclear neutrophils stimulated with interleukin-8. | 1992 | J. Biol. Chem. | pmid:1634507 |
| Ushiogi Y et al. | [Miscellaneous factors on mechanisms of blood pressure regulation]. | 1992 | Nippon Rinsho | pmid:1635219 |
| Mest HJ et al. | Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. | 1992 Feb-Mar | Pharmacol. Res. | pmid:1635894 |
| Lograno MD et al. | Effects of prostaglandins and PAF on the contractility of the bovine ciliary muscle. | 1992 Feb-Mar | Pharmacol. Res. | pmid:1635897 |
| Ozturk H et al. | PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. | 2006 | Pediatr. Surg. Int. | pmid:16369775 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Nakagawa Y et al. | Possible influence of lysophospholipase on the production of 1-acyl-2-acetylglycerophosphocholine in macrophages. | 1992 | Biochim. Biophys. Acta | pmid:1637856 |
| Sugiura T et al. | Distribution of alkyl and alkenyl ether-linked phospholipids and platelet-activating factor-like lipid in various species of invertebrates. | 1992 | Biochim. Biophys. Acta | pmid:1637858 |
| Ahmed A et al. | Platelet-activating factor mediates phosphatidylcholine hydrolysis by phospholipase D in human endometrium. | 1992 | Biol. Reprod. | pmid:1637948 |
| Faghiri Z and Bazan NG | Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16384990 |
| Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
| Blank ML et al. | Meats and fish consumed in the American diet contain substantial amounts of ether-linked phospholipids. | 1992 | J. Nutr. | pmid:1640259 |
| Wang CP et al. | [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16409839 |
| Snyder F et al. | The role of transacylases in the metabolism of arachidonate and platelet activating factor. | 1992 | Prog. Lipid Res. | pmid:1641397 |
| Uhlig S et al. | Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. | 2005 | Pharmacol Rep | pmid:16415501 |
| Kantorski J and Tchórzewski H | The effect of serine and thiol protease inhibitors on the chemiluminescence of human neutrophils in investigations in vitro. | 1992 | J. Biolumin. Chemilumin. | pmid:1642140 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Heinrich S et al. | Evidence-based treatment of acute pancreatitis: a look at established paradigms. | 2006 | Ann. Surg. | pmid:16432347 |
| Kojima S et al. | Existence of lipid vesicles containing platelet-activating factor in endothelial cell lysate. | 1992 | Biosci. Rep. | pmid:1643272 |
| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Kurose I et al. | Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1. | 1992 | Gut | pmid:1644323 |
| Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
| Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
| Dianzani C et al. | Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. | 2006 | J. Pharm. Pharmacol. | pmid:16451750 |
| Gopichandran N and Leese HJ | The effect of paracrine/autocrine interactions on the in vitro culture of bovine preimplantation embryos. | 2006 | Reproduction | pmid:16452720 |
| Fischer A et al. | The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. | 2006 | Chembiochem | pmid:16453359 |
| Dohi T et al. | Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells. | 1991 | Biochem. J. | pmid:1645529 |
| Wirthmueller U et al. | Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645549 |
| Kikuchi I et al. | Eosinophil trans-basement membrane migration induced by interleukin-8 and neutrophils. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16456187 |
| Smiley PL et al. | Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor. | 1991 | J. Biol. Chem. | pmid:1645725 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Warringa RA et al. | Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3. | 1991 | Blood | pmid:1646045 |
| Brecht HM et al. | Pharmacodynamics, pharmacokinetics and safety profile of the new platelet-activating factor antagonist apafant in man. | 1991 | Arzneimittelforschung | pmid:1646613 |
| Miyamoto A et al. | Interaction between PAF and drugs that stimulate formation of inositol phosphates. | 1991 | Gen. Pharmacol. | pmid:1646747 |
| Levine L | Effects of okadaic acid on agonist-stimulated PGI2 production by rat liver cells (the C-9 cell line). | 1991 | Prostaglandins | pmid:1647047 |
| Triggiani M et al. | Biological effects of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in the human neutrophil. | 1991 | Biochim. Biophys. Acta | pmid:1647203 |
| Rabinovici R et al. | Priming by platelet-activating factor of endotoxin-induced lung injury and cardiovascular shock. | 1991 | Circ. Res. | pmid:1647275 |
| Ezoulin MJ et al. | Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | 2006 | Toxicol In Vitro | pmid:16472967 |
| Braquet P et al. | Recent progress in ginkgolide research. | 1991 | Med Res Rev | pmid:1647474 |
| Randriamampita C et al. | Cyclic-GMP-dependent refilling of calcium stores in macrophages. | 1991 | Pflugers Arch. | pmid:1647519 |
| Kubes P et al. | Platelet-activating factor-induced mucosal dysfunction: role of oxidants and granulocytes. | 1991 | Am. J. Physiol. | pmid:1647676 |
| Marchand C et al. | Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. | 2006 | J. Cell. Biochem. | pmid:16479592 |
| Wang CJ and Tai HH | Monoclonal anti-idiotypic antibodies to platelet activating factor (PAF) and their interaction with PAF receptors. | 1991 | J. Biol. Chem. | pmid:1648095 |
| Brokaw JJ et al. | Effects of platelet-activating factor on vascular permeability and granulocyte recruitment in the rat trachea. | 1991 | Lung | pmid:1648156 |
| Buchanan MR | Biological basis and clinical implications of acetylsalicylic acid resistance. | 2006 | Can J Cardiol | pmid:16485051 |
| Liu LR and Xia SH | Role of platelet-activating factor in the pathogenesis of acute pancreatitis. | 2006 | World J. Gastroenterol. | pmid:16489665 |
| Faccioli LH et al. | The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo. | 1991 | Immunology | pmid:1649126 |
| Fleisher LN et al. | Lipid mediators of tumor necrosis factor-alpha-induced uveitis. | 1991 | Invest. Ophthalmol. Vis. Sci. | pmid:1649146 |
| Spitzer AL et al. | Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. | 2006 | Ann. Surg. | pmid:16495704 |
| Biancone L et al. | Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. | 2006 | Transplantation | pmid:16495796 |
| Flamand N et al. | Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. | 2006 | J. Leukoc. Biol. | pmid:16501051 |
| Thivierge M and Rola-Pleszczynski M | Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. | 1991 | Am. Rev. Respir. Dis. | pmid:1650153 |
| Zhang C et al. | Platelet activating factor-induced shock and intestinal necrosis in the rat: role of endogenous platelet-activating factor and effect of saline infusion. | 1991 | Crit. Care Med. | pmid:1650306 |
| He J and Bazan HE | Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16505020 |
| Dohi T et al. | [Role of platelet-activating factor on spinal pain transduction]. | 2006 | Nippon Yakurigaku Zasshi | pmid:16508219 |
| Floch A et al. | The platelet activating factor receptor antagonist, RP 59227, blocks platelet activating factor receptors mediating liberation of reactive oxygen species in guinea pig macrophages and human polymorphonuclear leukocytes. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1650834 |
| Morigi M et al. | Platelet-activating factor receptor blocking reduces proteinuria and improves survival in lupus autoimmune mice. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1650836 |
| Kurose I et al. | Involvement of superoxide anion and platelet-activating factor in increased tissue-type plasminogen activator during rat gastric microvascular damages. | 1991 | Thromb. Res. | pmid:1650966 |
| McMeekin SR et al. | E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. | 2006 | Blood | pmid:16514053 |
| Mizoguchi H | [Erythropoietin and thrombopoietin]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1651533 |
| Ramirez R et al. | Angiotensin II effect on hydraulic permeability: interaction with endothelin-1, nitric oxide, and platelet activating factor. | 2006 | J. Surg. Res. | pmid:16515797 |
| O'Flaherty JT et al. | Roles of Ca2+ in human neutrophil responses to receptor agonists. | 1991 | Biochem. J. | pmid:1651699 |
| He P et al. | Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16517944 |
| Hwang SB | High affinity receptor binding of platelet-activating factor in rat peritoneal polymorphonuclear leukocytes. | 1991 | Eur. J. Pharmacol. | pmid:1651872 |
| Yang YP et al. | Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. | 2006 | World J. Gastroenterol. | pmid:16521183 |
| Wang LJ et al. | [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16522243 |
| Hu W et al. | Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. | 1991 | Br. J. Pharmacol. | pmid:1652337 |
| Yamazaki M et al. | Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. | 1991 | Am. J. Physiol. | pmid:1653524 |
| Fernandes CJ and O'Donovan DJ | Platelet transfusions in infants with necrotizing enterocolitis. | 2006 | Curr. Hematol. Rep. | pmid:16537050 |
| Lamotte-Brasseur J et al. | PAF-receptor. III. Conformational and electronic properties of PAF-like agonists and antagonists. | 1991 | Biochim. Biophys. Acta | pmid:1654112 |
| Rougeot C et al. | Basal and PAF-, interleukin 1-, ether stress-induced hypothalamic pituitary adrenal secretion of conscious rat: modulation by PAF antagonists. | 1991 Jul-Aug | J Lipid Mediat | pmid:1654152 |
| Ong RC et al. | Activation mechanisms of platelet-activating factor in U937 cells: possible involvement of protein kinase C. | 1991 | Cell. Immunol. | pmid:1654212 |
| Gleason MM et al. | Comparison of endothelin binding and calcium mobilization in C6-BU-1 rat glioma and N18TG2 mouse neuroblastoma cells. | 1991 | Neuropeptides | pmid:1654531 |
| Hong SH et al. | Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia. | 2006 | J. Neurosci. Res. | pmid:16547968 |
| Rogers JE et al. | Solubilization of a functionally active platelet-activating factor receptor from rabbit platelets. | 1991 | Biochem. J. | pmid:1654881 |
| Tabarés-Seisdedos R et al. | Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study. | 2006 | Neuroscience | pmid:16549273 |
| Mizoguchi Y et al. | Effects of arachidonic acid metabolites and interleukin-1 on platelet activating factor production by hepatic sinusoidal endothelial cells from mice. | 1991 May-Jun | J. Gastroenterol. Hepatol. | pmid:1655098 |
| Palmantier R and Borgeat P | Thrombin-activated platelets promote leukotriene B4 synthesis in polymorphonuclear leucocytes stimulated by physiological agonists. | 1991 | Br. J. Pharmacol. | pmid:1655146 |
| Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
| Tomeo AC et al. | Priming interactions between platelet activating factor and histamine in the in vivo microcirculation. | 1991 | FASEB J. | pmid:1655549 |
| Lim WH and Stewart AG | Regulation of eicosanoid generation in activated macrophages. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1655656 |
| Balsinde J and Mollinedo F | Platelet-activating factor synergizes with phorbol myristate acetate in activating phospholipase D in the human promonocytic cell line U937. Evidence for different mechanisms of activation. | 1991 | J. Biol. Chem. | pmid:1655758 |
| Grimminger F et al. | Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction. | 1991 | J. Biol. Chem. | pmid:1655781 |
| Coëffier E et al. | Activation of guinea pig eosinophils by human recombinant IL-5. Selective priming to platelet-activating factor-acether and interference of its antagonists. | 1991 | J. Immunol. | pmid:1655895 |
| Herbert JM et al. | Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1656029 |
| Crowley HJ et al. | Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1656030 |
| Grimminger F et al. | Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils. | 1991 | Mol. Pharmacol. | pmid:1656192 |
| Han JI et al. | RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. | 2006 | J. Leukoc. Biol. | pmid:16565322 |
| Johnson A et al. | Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1991 | Am. J. Physiol. | pmid:1656789 |
| Ye RD et al. | Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1656963 |