| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Servillo L et al. | Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. | 2006 | FASEB J. | pmid:16571775 |
| Lee CM et al. | Prehispanolone, a novel platelet activating factor receptor antagonist from Leonurus heterophyllus. | 1991 | Br. J. Pharmacol. | pmid:1657264 |
| Corfield DR et al. | Mechanisms of platelet activating factor-induced changes in sheep tracheal blood flow. | 1991 | Br. J. Pharmacol. | pmid:1657266 |
| Kudolo GB et al. | Autoradiographic localization of platelet-activating factor (PAF) binding sites in the rabbit endometrium during the peri-implantation period. | 1991 | Cell Tissue Res. | pmid:1657393 |
| Nakamura M et al. | Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. | 1991 | J. Biol. Chem. | pmid:1657923 |
| Heller R et al. | Stimulation of platelet-activating factor synthesis in human endothelial cells by activation of the de novo pathway. Phorbol 12-myristate 13-acetate activates 1-alkyl-2-lyso-sn-glycero-3-phosphate:acetyl-CoA acetyltransferase and dithiothreitol-insensitive 1-alkyl-2-acetyl-sn-glycerol:CDP-choline cholinephosphotransferase. | 1991 | J. Biol. Chem. | pmid:1657961 |
| Thaete LG and Neerhof MG | Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. | 2006 | Am. J. Obstet. Gynecol. | pmid:16579936 |
| Karantonis HC et al. | In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits. | 2006 | Nutr Metab Cardiovasc Dis | pmid:16580585 |
| Balestrieri C et al. | Relative effects of phenolic constituents from Yucca schidigera Roezl. bark on Kaposi's sarcoma cell proliferation, migration, and PAF synthesis. | 2006 | Biochem. Pharmacol. | pmid:16580641 |
| O'Flaherty JT et al. | Tumor necrosis factor-alpha regulates expression of receptors for formyl-methionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils. | 1991 | J. Immunol. | pmid:1658151 |
| Walker BA et al. | Absence of FMLP receptors on rat macrophages. | 1991 | J. Leukoc. Biol. | pmid:1658174 |
| Travers JB et al. | Evidence for platelet-activating factor receptors in several B lymphoblastoid cell lines. | 1991 | Life Sci. | pmid:1658521 |
| Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
| Barnes PJ | Platelet activating factor and asthma. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659278 |
| Hwang SB | Function and regulation of extracellular and intracellular receptors of platelet activating factor. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659279 |
| O'Donnell M | Effects of Ro 24-4736 in antagonizing the platelet and bronchoconstrictor responses to PAF. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659287 |
| Fernández B and Balsinde J | Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659393 |
| Kuruvilla A et al. | High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659411 |
| Sánchez Crespo M and Fernández-Gallardo S | Pharmacological modulation of PAF: a therapeutic approach to endotoxin shock. | 1991 Sep-Oct | J Lipid Mediat | pmid:1659463 |
| Zoratti EM et al. | The effect of platelet-activating factor on the generation of superoxide anion in human eosinophils and neutrophils. | 1991 | J. Allergy Clin. Immunol. | pmid:1659593 |
| Coleus forskohlii. Monograph. | 2006 | Altern Med Rev | pmid:16597194 | |
| Gay JC and Murray JJ | Differential effects of propranolol on responses to receptor-dependent and receptor-independent stimuli in human neutrophils. | 1991 | Biochim. Biophys. Acta | pmid:1659906 |
| Ganong BR | Roles of lipid turnover in transmembrane signal transduction. | 1991 | Am. J. Med. Sci. | pmid:1661067 |
| Murphy CT et al. | Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. | 1991 | Biochim. Biophys. Acta | pmid:1661165 |
| Pitman JM et al. | WEB2170, a specific platelet-activating factor antagonist, attenuates neutrophil priming by human serum after clinical burn injury: the 1991 Moyer Award. | 1991 Sep-Oct | J Burn Care Rehabil | pmid:1661287 |
| Massey CV et al. | Molecular and cellular actions of platelet-activating factor in rat heart cells. | 1991 | J. Clin. Invest. | pmid:1661298 |
| Maliba R et al. | Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways. | 2006 | Cell. Signal. | pmid:16617006 |
| Taylor IK et al. | Inhaled PAF stimulates leukotriene and thromboxane A2 production in humans. | 1991 | J. Appl. Physiol. | pmid:1661723 |
| Ueda N et al. | Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. | 1991 | Kidney Int. | pmid:1662319 |
| Tou J et al. | Accumulation of phosphatidic acid mass and increased de novo synthesis of glycerolipids in platelet-activating-factor-activated human neutrophils. | 1991 | Biochem. J. | pmid:1662484 |
| Ostermann G et al. | Species-dependent differences of high affinity [3H]PAF-binding to platelets from humans and pigs and its inhibition by selected antagonists. | 1991 | J Lipid Mediat | pmid:1662546 |
| Stewart AG and Grigoriadis G | Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages. | 1991 | J Lipid Mediat | pmid:1662547 |
| Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
| Houlihan WJ et al. | Synthesis and pharmacology of a novel class of long-lasting PAF receptor antagonists. | 1991 Jan-Feb | J Lipid Mediat | pmid:1662991 |
| Wu T et al. | Platelet-activating factor stimulates eicosanoid production in cultured feline tracheal explants. | 1991 Nov-Dec | Exp. Lung Res. | pmid:1663033 |
| Nagaoka J et al. | Inhibitory effects of the novel platelet activating factor receptor antagonist, 1-ethyl-2-[N-(2-methoxy)benzoyl-N-[(2R)-2-methoxy-3-(4- octadecylcarbamoyloxy) piperidinocarbonyloxypropyloxy]carbonyl] aminomethyl-pyridinium chloride, in several experimentally induced shock models. | 1991 | Arzneimittelforschung | pmid:1663352 |
| Olivier JL et al. | Effects of platelet-activating factor (PAF), lyso-PAF and lysophosphatidylcholine on phosphatidylcholine bilayers, an ESR, 31P-NMR and X-ray diffraction study. | 1991 May-Jun | J Lipid Mediat | pmid:1663404 |
| Pugsley MK et al. | Actions of platelet-activating factor on isolated rat hearts. | 1991 | Circ. Shock | pmid:1663843 |
| Vandongen R | Platelet activating factor and the circulation. | 1991 | J. Hypertens. | pmid:1663976 |
| McMillan RM and Carter GW | Design and development of drugs. | 1991 | Agents Actions Suppl. | pmid:1664186 |
| Pedersen KE et al. | Quantitative assessment of increased airway microvascular permeability to 125I-labelled plasma fibrinogen induced by platelet activating factor and bradykinin. | 1991 | Br. J. Pharmacol. | pmid:1664758 |
| Grigoriadis G and Stewart AG | 1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet-activating factor with partial agonist activity. | 1991 | Br. J. Pharmacol. | pmid:1664761 |
| Heon Seo K et al. | Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation. | 2006 | Cancer Res. | pmid:16651419 |
| Doi K et al. | Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. | 2006 | Am. J. Pathol. | pmid:16651609 |
| Desaulniers P et al. | Characterization of an activation factor released from human neutrophils after stimulation by triclinic monosodium urate crystals. | 2006 | J. Rheumatol. | pmid:16652423 |
| Chan WP and Levy JV | Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. | 1991 | Prostaglandins | pmid:1665568 |
| Stewart AG and Harris T | Involvement of platelet-activating factor in endotoxin-induced priming of rabbit polymorphonuclear leukocytes. | 1991 Mar-Apr | J Lipid Mediat | pmid:1665713 |
| Salvidio G et al. | Receptor antagonists of platelet-activating factor do not influence the development of passive Heymann nephritis. | 1991 Mar-Apr | J Lipid Mediat | pmid:1665716 |
| Alving K et al. | Effect of nedocromil sodium on allergen-, PAF-, histamine- and bradykinin-induced airways vasodilatation and pulmonary obstruction in the pig. | 1991 | Br. J. Pharmacol. | pmid:1665736 |
| Sagach VF and Zhukova AV | [The effect of platelet-activating factor on cardio- and hemodynamics]. | 1991 | Fiziol Zh SSSR Im I M Sechenova | pmid:1666599 |
| Peng SY et al. | Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. | 2006 | Yao Xue Xue Bao | pmid:16671547 |
| Schauer U et al. | Enhanced superoxide generation by eosinophils from asthmatic children. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1667183 |
| Hu WM and Man RY | Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart. | 1991 | Br. J. Pharmacol. | pmid:1667284 |
| Filep JG et al. | Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor. | 1991 | Br. J. Pharmacol. | pmid:1667286 |
| Miller LG et al. | Platelet activating factor antagonists interact with GABAA receptors. | 1991 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1667341 |
| Bate C et al. | Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. | 2006 | Neuropharmacology | pmid:16678220 |
| Sánchez FA et al. | Functional significance of differential eNOS translocation. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16679407 |
| Yue TL et al. | Platelet-activating factor (PAF)--a putative mediator in inflammatory tissue injury. | 1991 | Adv. Exp. Med. Biol. | pmid:1667965 |
| Chou CT et al. | Neutrophil chemiluminescence and superoxide production in patients with rheumatoid arthritis: the effect of zymosan, phorbol myristate acetate and platelet-activating factor. | 1991 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:1667989 |
| Shukla SD | Inositol phospholipid turnover in PAF transmembrane signalling. | 1991 | Lipids | pmid:1668102 |
| Gandhi CR and Olson MS | PAF effects on transmembrane signaling pathways in rat Kupffer cells. | 1991 | Lipids | pmid:1668103 |
| Stewart AG and Harris T | Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes. | 1991 | Lipids | pmid:1668104 |
| Ruis NM et al. | Tumor necrosis factor release by human monocytes stimulated with platelet-activating factor. | 1991 | Lipids | pmid:1668105 |
| Kudo I et al. | Guinea pig bone marrow cells treated with platelet-activating factor generate factor(s) which affects their DNA synthesis and microbicidal activity. | 1991 | Lipids | pmid:1668106 |
| Braquet P et al. | Effect of platelet-activating factor on tumor necrosis factor-induced superoxide generation from human neutrophils. Possible involvement of G proteins. | 1991 | Lipids | pmid:1668107 |
| Chau LY | Protein kinase C is not involved in the desensitization of platelet activating factor receptor in rabbit platelets. | 1991 | Lipids | pmid:1668108 |
| Hwang SB and Lam MH | L-659,989: a useful probe in the detection of multiple conformational states of PAF receptors. | 1991 | Lipids | pmid:1668109 |
| Shen TY | Chemical and biochemical characterization of lignan analogs as novel PAF receptor antagonists. | 1991 | Lipids | pmid:1668110 |
| Casals-Stenzel J | Thieno-triazolo-1,4-diazepines as antagonists of platelet-activating factor: present status. | 1991 | Lipids | pmid:1668111 |
| Godfroid JJ et al. | PAF receptor structure: a hypothesis. | 1991 | Lipids | pmid:1668112 |
| Lamotte-Brasseur J et al. | PAF receptor and "Cache-oreilles" effect. Simple PAF antagonists. | 1991 | Lipids | pmid:1668113 |
| Yamada T et al. | Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist. | 1991 | Lipids | pmid:1668114 |
| Rossi AG and O'Flaherty JT | Bioactions of 5-hydroxyicosatetraenoate and its interaction with platelet-activating factor. | 1991 | Lipids | pmid:1668115 |
| Ammit AJ and O'Neill C | Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood. | 1991 | Lipids | pmid:1668116 |
| Hayashi H et al. | Biological response of guinea pig peritoneal macrophages to platelet-activating factor. | 1991 | Lipids | pmid:1668117 |
| Pustynnikov MG et al. | Platelet-activating factor stimulates receptor-mediated formation of reactive oxygen intermediates in human monocytes. | 1991 | Lipids | pmid:1668118 |
| Takahashi S et al. | Role of platelet-activating factor (PAF) in superoxide production by human polymorphonuclear leukocytes. | 1991 | Lipids | pmid:1668119 |
| Hernando P et al. | IgA immune aggregates stimulate platelet-activating factor and superoxide anion production by human neutrophils. A comparison with IgG aggregates. | 1991 | Lipids | pmid:1668120 |
| Bazan NG et al. | Platelet-activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: intracellular PAF-binding sites and activation of a fos/jun/AP-1 transcriptional signaling system. | 1991 | Lipids | pmid:1668121 |
| Suematsu M and Tsuchiya M | Platelet-activating factor and granulocyte-mediated oxidative stress. Strategy for in vivo oxyradical visualization. | 1991 | Lipids | pmid:1668122 |
| Amorim CZ et al. | Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. | 1991 | Lipids | pmid:1668123 |
| Mao YJ et al. | [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. | 2006 | Yao Xue Xue Bao | pmid:16683525 |
| Ko HM et al. | Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. | 2006 | FEBS Lett. | pmid:16684540 |
| Hruby ZW et al. | Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. | 1991 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:1668710 |
| Gottlieb OR | The rational search for natural neolignans. | 1991 | Mem. Inst. Oswaldo Cruz | pmid:1668770 |
| Goldring WP and Pattenden G | The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes. | 2006 | Acc. Chem. Res. | pmid:16700534 |
| McLaughlin NJ et al. | Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. | 2006 | J. Immunol. | pmid:16709866 |
| Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
| Hsu HC et al. | Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16712790 |
| Piwinski JJ et al. | Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. | 1991 | J. Med. Chem. | pmid:1671420 |
| Mathonnet M et al. | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. | 2006 | World J. Gastroenterol. | pmid:16718768 |
| Pons L et al. | Role of free radicals and platelet-activating factor in the genesis of intestinal motor disturbances induced by Escherichia coli endotoxins in rats. | 1991 | Gastroenterology | pmid:1672116 |
| Cellai C et al. | Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | 2006 | Br. J. Cancer | pmid:16721373 |
| Hermle T et al. | Decreased cation channel activity and blunted channel-dependent eryptosis in neonatal erythrocytes. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16723509 |
| Fisher MA et al. | Thrombin-mediated release of lipids from pulmonary artery endothelial cells promotes neutrophil adherence. | 1991 | Circ. Res. | pmid:1672631 |
| Verhoef G and Boogaerts M | Treatment with granulocyte-macrophage colony stimulating factor and the adult respiratory distress syndrome. | 1991 | Am. J. Hematol. | pmid:1672790 |
| Fonseca FV et al. | Characterization of a new platelet aggregating factor from crotoxin Crotalus durissus cascavella venom. | 2006 | Protein J. | pmid:16729248 |
| Symposium on The Clinical Importance of Leukotrienes and Platelet-activating Factor in Allergic Respiratory Diseases. November 14, 1990, San Francisco, California. | 1991 | Am. Rev. Respir. Dis. | pmid:1673326 | |
| Kishino J et al. | Synergistic effect of thromboxane A2 and N-formylmethionylleucylphenylalanine on platelet-activating factor synthesis in human polymorphonuclear neutrophils. | 1991 | Biochim. Biophys. Acta | pmid:1673352 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |