| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bussolati B et al. | Platelet-activating factor synthesized by IL-12-stimulated polymorphonuclear neutrophils and NK cells mediates chemotaxis. | 1998 | J. Immunol. | pmid:9686616 |
| da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
| Peçanha EP et al. | Synthesis and pharmacological evaluation of a new class of bicyclic phospholipids, designed as platelet activating factor antagonists. | 1998 | Farmaco | pmid:9679282 |
| Barber LA et al. | Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line. | 1998 | J. Biol. Chem. | pmid:9668065 |
| Tuder RM and Voelkel NF | Pulmonary hypertension and inflammation. | 1998 | J. Lab. Clin. Med. | pmid:9665367 |
| Manya H et al. | Switching of platelet-activating factor acetylhydrolase catalytic subunits in developing rat brain. | 1998 | J. Biol. Chem. | pmid:9660828 |
| Akisü M et al. | Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine. | 1998 | Biol. Neonate | pmid:9657667 |
| Ahmed A et al. | Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125. | 1998 | FASEB J. | pmid:9657523 |
| Rainger GE et al. | Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation. | 1998 | Thromb. Haemost. | pmid:9657445 |
| Schwartz JD et al. | Cardiopulmonary bypass primes polymorphonuclear leukocytes. | 1998 | J. Surg. Res. | pmid:9655092 |
| Loucks EB et al. | Platelet-activating factor antagonism: a new concept in the management of regional myocardial ischemia-reperfusion injury. | 1997 Nov-Dec | J Invest Surg | pmid:9654389 |
| Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
| Ginkgo biloba for dementia. | 1998 | Med Lett Drugs Ther | pmid:9653424 | |
| Küçükhüseyin C et al. | On the mechanisms of adenosine induced pulmonary vasoconstriction in rats. | 1997 | J Basic Clin Physiol Pharmacol | pmid:9651801 |
| Roudebush WE and Mathur RS | Presence of platelet-activating factor in squirrel monkey (Saimiri boliviensis) spermatozoa: seasonal differences. | 1998 | Am. J. Primatol. | pmid:9651652 |
| Perry SW et al. | Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. | 1998 | J. Biol. Chem. | pmid:9651362 |
| Minamiya Y et al. | Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651191 |
| Han BH et al. | In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study. | 1998 | J. Med. Chem. | pmid:9651167 |
| Shindo K et al. | Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. | 1998 | Eur. Respir. J. | pmid:9648962 |
| Matsumoto K et al. | Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. | 1998 | J. Allergy Clin. Immunol. | pmid:9648711 |
| Watson F and Edwards SW | Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647777 |
| Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
| Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
| Derewenda ZS and Derewenda U | The structure and function of platelet-activating factor acetylhydrolases. | 1998 | Cell. Mol. Life Sci. | pmid:9645224 |
| Jung KY et al. | Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. | 1998 | J. Nat. Prod. | pmid:9644071 |
| Botitsi E et al. | Metabolic fate of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) in FRTL5 cells. | 1998 | J. Lipid Res. | pmid:9643362 |
| Mackness B et al. | Lack of protection against oxidative modification of LDL by avian HDL. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642147 |
| Izuoka T et al. | Role of platelet-activating factor on extravascular lung water after coronary reperfusion in dogs. | 1998 | Jpn. J. Physiol. | pmid:9639551 |
| Grassi S et al. | Role of platelet-activating factor in long-term potentiation of the rat medial vestibular nuclei. | 1998 | J. Neurophysiol. | pmid:9636125 |
| Beck-Speier I et al. | Pro-inflammatory response of alveolar macrophages induced by sulphite: studies with lucigenin-dependent chemiluminescence. | 1998 Mar-Apr | J. Biolumin. Chemilumin. | pmid:9633012 |
| Baker RR and Chang H | MgATP has different inhibitory effects on the use of 1-acyl-lysophosphatidylcholine and lyso platelet-activating factor acceptors by neuronal nuclear acetyltransferase activities. | 1998 | Biochim. Biophys. Acta | pmid:9630721 |
| De Plaen IG et al. | Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. | 1998 | Biochim. Biophys. Acta | pmid:9630621 |
| Spapen H et al. | The platelet-activating factor antagonist BB-882 does not improve tissue oxygen extraction in endotoxic shock. | 1998 | J Crit Care | pmid:9627275 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Werr J et al. | beta1 integrins are critically involved in neutrophil locomotion in extravascular tissue In vivo. | 1998 | J. Exp. Med. | pmid:9625769 |
| Gómez FP et al. | Effect of a platelet-activating factor (PAF) antagonist, SR 27417A, on PAF-induced gas exchange abnormalities in mild asthma. | 1998 | Eur. Respir. J. | pmid:9623685 |
| Isumi H et al. | Expression of a 45K subunit of platelet-activating factor acetylhydrolase in the developing mouse cerebellum. | 1998 | Anat. Embryol. | pmid:9623676 |
| Lapchyns'ka II | [Platelet activating factor and its role in the pathogenesis of immune glomerulopathy]. | 1998 Jan-Feb | Lik. Sprava | pmid:9621619 |
| Lou YP et al. | Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620929 |
| Mollinedo F et al. | Physiological activation of human neutrophils down-regulates CD53 cell surface antigen. | 1998 | J. Leukoc. Biol. | pmid:9620662 |
| Shimada A et al. | In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. | 1998 | J. Invest. Dermatol. | pmid:9620295 |
| Tsuji F and Shirasawa E | The role of platelet-activating factor in cell infiltration in endotoxin-induced uveitis in guinea pigs. | 1998 | Curr. Eye Res. | pmid:9617545 |
| Nakos G et al. | Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. | 1998 | Intensive Care Med | pmid:9609406 |
| Nguyen P et al. | [Modulators of leukocytic functions]. | 1998 | J Mal Vasc | pmid:9608925 |
| ZaÄtseva LG et al. | [The role of platelet activating factor in regulation of the phagocytic function of macrophages from different organs]. | 1998 | Biull Eksp Biol Med | pmid:9606554 |
| Kotelevets L et al. | Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. | 1998 | J. Biol. Chem. | pmid:9603913 |
| O'Neill C | Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. | 1998 | Biol. Reprod. | pmid:9603268 |
| Gómez FP et al. | The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9603138 |
| László F and Whittle BJ | Role of nitric oxide and platelet-activating factor in the initiation of indomethacin-provoked intestinal inflammation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9600654 |
| Giménez R and Aguilar J | Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats. | 1998 | Eur. J. Pharmacol. | pmid:9600649 |