| MeSH term | MeSH ID | Detail |
|---|---|---|
| Amnesia, Anterograde | D020324 | 2 associated lipids |
| Dementia, Multi-Infarct | D015161 | 2 associated lipids |
| Toxemia | D014115 | 3 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Pneumonia, Pneumococcal | D011018 | 3 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Ileal Diseases | D007077 | 3 associated lipids |
| Platelet Storage Pool Deficiency | D010981 | 3 associated lipids |
| Colitis, Ischemic | D017091 | 3 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
| Heptinstall S and Bevan J | How can we inhibit 5-HT-induced platelet aggregation and why should we bother? | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465956 |
| Bodzenta-Lukaszyk A et al. | Blood platelet function in patients with obliterative arteriosclerosis of the lower limbs. | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465957 |
| Terashita Z et al. | Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. | 1988 | J. Cardiovasc. Pharmacol. | pmid:2468048 |
| Smith SK and Kelly RW | Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium. | 1988 | J. Reprod. Fertil. | pmid:3422322 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Yoshida K et al. | PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. | 1988 | Prog Biochem Pharmacol | pmid:2457219 |
| Elstad MR et al. | Synthesis and release of platelet-activating factor by stimulated human mononuclear phagocytes. | 1988 | J. Immunol. | pmid:3126231 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Nasmith PE and Grinstein S | Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. | 1988 | Biosci. Rep. | pmid:2840131 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether. I. Effect of paf-acether on CD4+ cell proliferation. | 1988 | J. Immunol. | pmid:2961808 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Yamada K et al. | Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. | 1988 | Biochem. Pharmacol. | pmid:3128296 |
| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
| Levine L | Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism. | 1988 | Mol. Pharmacol. | pmid:2849046 |
| Neuwirth R et al. | Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. | 1988 | J. Clin. Invest. | pmid:3166467 |
| Rossi AG et al. | Stereospecific bioactions of 5-hydroxyeicosatetraenoate. | 1988 | FEBS Lett. | pmid:3191990 |
| Nakamura T et al. | Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2898372 |
| Sessler CN et al. | Effects of platelet-activating factor antagonist SRI 63-441 on endotoxemia in sheep. | 1988 | J. Appl. Physiol. | pmid:3145934 |
| Del Monte M and Subissi A | Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3149718 |
| Hofmann B et al. | Effects of synthetic analogues of platelet-activating factor (PAF) on fibrinolytic activity in the rat. | 1988 | Biomed. Biochim. Acta | pmid:3150268 |
| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, of antagonists of the eicosanoids and of PAF on mortality assayed in three biochemically characterized shock models. | 1988 | Biomed. Biochim. Acta | pmid:3150272 |
| Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
| Handley DA et al. | Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3183958 |
| Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
| Miyazawa K et al. | Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. | 1988 | J. Immunol. | pmid:3385211 |
| Etienne A et al. | Role of neutrophils in gastric damage induced by platelet activating factor. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3244384 |
| Archer CB et al. | Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. | 1988 | J. Invest. Dermatol. | pmid:3385217 |
| Taylor RR et al. | Time dependence of whole blood aggregation in response to platelet activating factor (PAF). | 1988 | Thromb. Haemost. | pmid:3388292 |
| Powling MJ and Hardisty RM | Potentiation by adrenaline of Ca2+ influx and mobilization in stimulated human platelets: dissociation from thromboxane generation and aggregation. | 1988 | Thromb. Haemost. | pmid:3388294 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Demopoulos CA et al. | Abnormal platelet response to PAF and ADP in beta-thalassaemia. | 1988 | Int. J. Biochem. | pmid:3391336 |
| Christman BW et al. | Role of circulating platelets and granulocytes in PAF-induced pulmonary dysfunction in awake sheep. | 1988 | J. Appl. Physiol. | pmid:3391901 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Pirotzky E and Braquet P | PAF-acether and kidney pathology. | 1988 | Prog Biochem Pharmacol | pmid:3043431 |
| Feuerstein G and Siren AL | Platelet-activating factor and shock. | 1988 | Prog Biochem Pharmacol | pmid:3043432 |
| Mazière JC et al. | PAF-acether decreases low density lipoprotein degradation and alters lipid metabolism in cultured human fibroblasts. | 1988 | FEBS Lett. | pmid:3402608 |
| Godfroid JJ and Heymans F | Chemistry of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043433 |
| Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
| Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
| Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
| Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
| Ojima-Uchiyama A et al. | Phospholipid analysis of human eosinophils: high levels of alkylacylglycerophosphocholine (PAF precursor). | 1988 | Lipids | pmid:3185116 |
| Skeaff CM and Holub BJ | The effect of fish oil consumption on platelet aggregation responses in washed human platelet suspensions. | 1988 | Thromb. Res. | pmid:3187952 |
| Griffin KJ and Levy JV | The thieno-triazolodiazepine WEB 2086 inhibits platelet aggregation and ATP release from porcine platelets induced by platelet activating factor (PAF). | 1988 | Thromb. Res. | pmid:3187959 |
| Braquet P et al. | Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations. | 1988 | Eur. J. Pharmacol. | pmid:3046952 |
| Barr R et al. | The effect of platelet activating factor on electron transport of spinach chloroplasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3048258 |
| Camussi G et al. | Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases. | 1988 | J. Exp. Med. | pmid:3049910 |
| Cahill M et al. | Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. | 1988 | Agents Actions | pmid:3051930 |
| Page CP et al. | Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs. | 1988 | Agents Actions Suppl. | pmid:3051932 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Wasserman SI | Platelet-activating factor as a mediator of bronchial asthma. | 1988 | Hosp. Pract. (Off. Ed.) | pmid:3053741 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Foegh ML | Eicosanoids and platelet activating factor mechanisms in organ rejection. | 1988 | Transplant. Proc. | pmid:3059615 |
| Chu KM et al. | Local vasodilator effect of platelet activating factor in the gastric, mesenteric and femoral arteries of the dog. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3418522 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
| Lee TC et al. | Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens. | 1988 | J. Biol. Chem. | pmid:2828351 |
| Nieto ML et al. | Biosynthesis of platelet-activating factor in human polymorphonuclear leukocytes. Involvement of the cholinephosphotransferase pathway in response to the phorbol esters. | 1988 | J. Biol. Chem. | pmid:2828363 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Braquet P et al. | Platelet activating factor as a mediator in cerebral ischemia and related disorders. | 1988 | Biomed. Biochim. Acta | pmid:3073761 |
| Hwang SB | Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. | 1988 | J. Biol. Chem. | pmid:2830276 |
| Marquis O et al. | [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2831350 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| Arnoux B et al. | Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. | 1988 | Am. Rev. Respir. Dis. | pmid:3354991 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Wainwright CL et al. | The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation. | 1988 | Biomed. Biochim. Acta | pmid:3248108 |
| Dembińska-Kieć A et al. | Release of cysteinyl-leukotrienes is of minor importance in PAF induced reduction of perfusion rate in the gastric vascular bed. | 1988 | Biomed. Biochim. Acta | pmid:3248109 |
| Ostermann G et al. | Structure-activity relationships of synthetic analogues of platelet-activating factor. | 1988 | Biomed. Biochim. Acta | pmid:3248110 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Stahl GL et al. | Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252036 |
| Williams WR et al. | Plates and anti-asthma drugs. | 1988 | Pneumonol Pol | pmid:3254508 |
| Archer CB | Mediators of heat urticaria. | 1988 | Clin. Exp. Dermatol. | pmid:3256463 |
| Morell GP et al. | Paf-acether (platelet-activating factor) and interleukin-1-like cytokine production by lipopolysaccharide-stimulated glomeruli. | 1988 | Clin. Immunol. Immunopathol. | pmid:3257432 |
| Pignol B et al. | Potentiation of immunosuppressive action of cyclosporine A by platelet-activating factor antagonists: an approach of the mechanism of action of these drugs in the prevention of graft rejection. | 1988 | Transplant. Proc. | pmid:3259039 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Bussolino F et al. | Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha. | 1988 | J. Biol. Chem. | pmid:3261295 |
| Croft KD et al. | The effect of dietary fish oil and long-term salt loading on blood pressure and eicosanoid metabolism in spontaneously hypertensive rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3271614 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Wykle RL et al. | Platelet-activating factor. | 1988 | Meth. Enzymol. | pmid:3237085 |
| Kioumis I et al. | Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. | 1988 | Prostaglandins | pmid:3237997 |
| Sirois MG et al. | PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | 1988 | Prostaglandins | pmid:3238010 |
| Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
| Silva PM et al. | Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats. | 1988 | Braz. J. Med. Biol. Res. | pmid:3240383 |
| Fradin A et al. | Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. | 1988 | Biochim. Biophys. Acta | pmid:2848583 |
| Fichelle J et al. | Bronchospasmolytic effects of RU 42173. | 1988 | Fundam Clin Pharmacol | pmid:3240917 |
| Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
| Yasuda K et al. | Acyl type platelet-activating factor in normal rat uterus determined by gas chromatography mass spectrometry. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242662 |
| Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |
| Mallet AI | Analysis of lyso-platelet activating factor by negative ion gas chromatography/mass spectrometry of the nitrobenzal acetal derivatives. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242671 |
| Suzuki S et al. | [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. | 1988 | Nihon Jinzo Gakkai Shi | pmid:3244194 |
| Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |