Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemorrhagic Fever, American D006478 2 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Toxemia D014115 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Ambrosio G and Tritto I Reperfusion injury: experimental evidence and clinical implications. 1999 Am. Heart J. pmid:10426862
Maruyama M et al. Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs. 1990 Am. Heart J. pmid:2389687
Schwinger RH et al. Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium. 1992 Am. Heart J. pmid:1322030
Kwiterovich PO The antiatherogenic role of high-density lipoprotein cholesterol. 1998 Am. J. Cardiol. pmid:9819099
Madsen NJ et al. Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. 2007 Am. J. Cardiol. pmid:17697836
Shohet RV et al. Plasma platelet-activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis. 1999 Am. J. Cardiol. pmid:10073795
Zhang C et al. The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. 2004 Am. J. Chin. Med. pmid:15154282
Prescott SM What are the effects of dietary fatty acid modification on platelet eicosanoid metabolism, platelet-activating factor, and platelet function? How might these metabolic alterations influence thrombosis? 1992 Am. J. Clin. Nutr. pmid:1414987
Sandler RM et al. Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. 1985 Am. J. Clin. Pathol. pmid:4003343
Sandberg-Gertzén H An open trial of Cedemin, a Gingko biloba extract with PAF-antagonistic effects for ulcerative colitis. 1993 Am. J. Gastroenterol. pmid:8470656
Braquet P Cedemin, a Ginkgo biloba extract, should not be considered as a PAF antagonist. 1993 Am. J. Gastroenterol. pmid:8110248
Verhoef G and Boogaerts M Treatment with granulocyte-macrophage colony stimulating factor and the adult respiratory distress syndrome. 1991 Am. J. Hematol. pmid:1672790
Rao AK et al. Platelet-activating factor is a weak platelet agonist: evidence from normal human platelets and platelets with congenital secretion defects. 1984 Am. J. Hematol. pmid:6431801
Issekutz AC and Ripley M The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. 1986 Am. J. Hematol. pmid:2934975
Radhika V et al. Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants. 1996 Am. J. Hematol. pmid:8756080
Lo GK et al. What is the potential for overdiagnosis of heparin-induced thrombocytopenia? 2007 Am. J. Hematol. pmid:17722079
Marx G et al. Nutritional zinc increases platelet reactivity. 1991 Am. J. Hematol. pmid:1951315
Pelczar-Wissner CJ et al. Absence of platelet activating factor (PAF) mediated platelet aggregation: a new platelet defect. 1984 Am. J. Hematol. pmid:6720685
Yoshida H et al. Activity of platelet-activating factor acetylhydrolase exists in red cell membrane. 1992 Am. J. Hematol. pmid:1566749
Greinacher A Too many hits in HIT? 2007 Am. J. Hematol. pmid:17729242
Hollister AS et al. Humoral factor, intraplatelet calcium, and hypertension. 1992 Am. J. Hypertens. pmid:1632935
Macconi D et al. Defective platelet aggregation in response to platelet-activating factor in uremia associated with low platelet thromboxane A2 generation. 1992 Am. J. Kidney Dis. pmid:1562019
Tetta C et al. Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. 1997 Am. J. Kidney Dis. pmid:9372980
Tanaka R et al. Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. 1999 Am. J. Kidney Dis. pmid:10430976
Hall AV et al. Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. 1993 Am. J. Kidney Dis. pmid:8352261
Gallego MJ et al. Cyclosporine enhances leukocyte adhesion to vascular endothelium under physiologic flow conditions. 1996 Am. J. Kidney Dis. pmid:8712218
Xu H et al. Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. 2000 Am. J. Kidney Dis. pmid:10873870
Barnes PJ Inflammatory mechanisms and nocturnal asthma. 1988 Am. J. Med. pmid:3041827
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
Wright NR et al. Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. 2016 Am. J. Med. pmid:26524710
Ganong BR Roles of lipid turnover in transmembrane signal transduction. 1991 Am. J. Med. Sci. pmid:1661067
Muirhead EE et al. Biologic contrasts between medullipin I and vasoactive glyceryl compounds. 1989 Am. J. Med. Sci. pmid:2764021
Gaylord MS et al. Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. 1996 Am. J. Med. Sci. pmid:8853062
Pitcock JA Morphometric studies of the renomedullary interstitial cells. 1988 Am. J. Med. Sci. pmid:3284348
Perico N and Remuzzi G Role of platelet-activating factor in renal immune injury and proteinuria. 1990 Am. J. Nephrol. pmid:2256482
Kees-Folts D and Diamond JR Relationship between hyperlipidemia, lipid mediators, and progressive glomerulosclerosis in the nephrotic syndrome. 1993 Am. J. Nephrol. pmid:8116689
Camussi G et al. Platelet-activating factor in renal diseases. 1989 Am. J. Nephrol. pmid:2646923
Wild MD and Roudebush WE Platelet-activating factor improves intrauterine insemination outcome. 2001 Am. J. Obstet. Gynecol. pmid:11349157
Hoffman DR et al. The role of platelet-activating factor in human fetal lung maturation. 1986 Am. J. Obstet. Gynecol. pmid:3728606
Tabor BL et al. Platelet-activating factor antagonists decrease lung protein leak in preterm ventilated rabbits. 1992 Am. J. Obstet. Gynecol. pmid:1530043
Narahara H and Johnston JM Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. 1993 Am. J. Obstet. Gynecol. pmid:8372856
Claman P Platelet activating factor does not improve intrauterine insemination outcome. 2001 Am. J. Obstet. Gynecol. pmid:11717679
Benedetto C et al. Reduced serum inhibition of platelet-activating factor activity in preeclampsia. 1989 Am. J. Obstet. Gynecol. pmid:2912073
Morris C et al. Effects of platelet-activating factor on prostaglandin E2 production by intact fetal membranes. 1992 Am. J. Obstet. Gynecol. pmid:1566774
Maul H et al. Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. 2002 Am. J. Obstet. Gynecol. pmid:12388958
Zhu YP et al. The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. 1992 Am. J. Obstet. Gynecol. pmid:1314480
Rowland BL et al. Elevated circulating concentrations of platelet activating factor in preeclampsia. 2000 Am. J. Obstet. Gynecol. pmid:11035340
Matorras R and Pijoan JI The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. 2002 Am. J. Obstet. Gynecol. pmid:11904634
Hoffman DR et al. Detection of platelet-activating factor in amniotic fluid of complicated pregnancies. 1990 Am. J. Obstet. Gynecol. pmid:2309839
Thaete LG and Neerhof MG Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. 2006 Am. J. Obstet. Gynecol. pmid:16579936
Roudebush WE et al. Platelet activating factor enhances in vitro fertilization of rabbit oocytes. 1990 Am. J. Obstet. Gynecol. pmid:2240122
Minhas BS et al. Effects of platelet activating factor on mouse oocyte fertilization in vitro. 1989 Am. J. Obstet. Gynecol. pmid:2603931
Frostegård J et al. Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. 2003 Am. J. Obstet. Gynecol. pmid:14520236
Silver RK et al. Anticardiolipin antibody-positive serum enhances endothelial cell platelet-activating factor production. 1991 Am. J. Obstet. Gynecol. pmid:1750472
Minhas BS Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. 1993 Am. J. Obstet. Gynecol. pmid:8475981
Sueoka K et al. Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. 1988 Am. J. Obstet. Gynecol. pmid:3207134
Montrucchio G et al. Potential angiogenic role of platelet-activating factor in human breast cancer. 1998 Am. J. Pathol. pmid:9811351
O'Flaherty JT et al. Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. 1981 Am. J. Pathol. pmid:6274199
Reznichenko A and Korstanje R The role of platelet-activating factor in mesangial pathophysiology. 2015 Am. J. Pathol. pmid:25655028
Rampart M and Williams TJ Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. 1986 Am. J. Pathol. pmid:3524253
Lehr HA et al. In vitro effects of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation. 1995 Am. J. Pathol. pmid:7531948
Byrne SN et al. The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. 2011 Am. J. Pathol. pmid:21703403
Montrucchio G et al. Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. 1997 Am. J. Pathol. pmid:9250168
Zhou WG et al. Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat. 1990 Am. J. Pathol. pmid:1701964
O'Flaherty JT et al. 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. 1981 Am. J. Pathol. pmid:7223864
Boccellino M et al. Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. 2005 Am. J. Pathol. pmid:15855650
Montrucchio G et al. Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart. 1990 Am. J. Pathol. pmid:2372044
Singh TP et al. Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. 2011 Am. J. Pathol. pmid:21281802
Koyama S et al. Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. 1998 Am. J. Pathol. pmid:9846978
Masubuchi T et al. Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. 1998 Am. J. Pathol. pmid:9846980
Stimler NP and O'Flaherty JT Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. 1983 Am. J. Pathol. pmid:6624879
Wolf P et al. Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. 2006 Am. J. Pathol. pmid:16936256
Warren JS Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. 1992 Am. J. Pathol. pmid:1519663
Flickinger BD and Olson MS Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. 1999 Am. J. Pathol. pmid:10329588
O'Flaherty JT et al. Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. 1981 Am. J. Pathol. pmid:6271016
Souza-Fiho MV et al. Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. 1997 Am. J. Pathol. pmid:9006340
Valone FH and Goetzl EJ Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC). 1983 Am. J. Pathol. pmid:6624880
Bussolati B et al. PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. 2000 Am. J. Pathol. pmid:11073830
Sun XM et al. Effects of in vivo 'priming' on endotoxin-induced hypotension and tissue injury. The role of PAF and tumor necrosis factor. 1990 Am. J. Pathol. pmid:2327475
Doi K et al. Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. 2006 Am. J. Pathol. pmid:16651609
McManus LM and Pinckard RN Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. 1985 Am. J. Pathol. pmid:4050977
Montrucchio G et al. Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart. 1993 Am. J. Pathol. pmid:8434642
Hsueh W et al. Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. 1986 Am. J. Pathol. pmid:3080895
Bussolati B et al. Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. 1999 Am. J. Pathol. pmid:10027419
Elovitz MA et al. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. 2003 Am. J. Pathol. pmid:14578208
Gonzalez-Crussi F and Hsueh W Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin. 1983 Am. J. Pathol. pmid:6859226
Camussi G et al. Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. 1983 Am. J. Pathol. pmid:6859232
Kispert S et al. Cigarette Smoke Regulates Calcium-Independent Phospholipase A Metabolic Pathways in Breast Cancer. 2017 Am. J. Pathol. pmid:28618256
Stimler NP et al. Anaphylactic actions of platelet-activating factor. 1981 Am. J. Pathol. pmid:6975043
Shaw JO and Henson PM The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. 1980 Am. J. Pathol. pmid:6987890
Zhou W et al. Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. 1992 Am. J. Pathol. pmid:1562055
Zhou W et al. Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. 1993 Am. J. Pathol. pmid:8494049
Humphrey DM Inflammatory exudates in skin windows induced by 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine. 1990 Am. J. Pathol. pmid:2407127
Biancone L et al. Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. 1999 Am. J. Pathol. pmid:10550329
Emanuelli G et al. Experimental acute pancreatitis induced by platelet activating factor in rabbits. 1989 Am. J. Pathol. pmid:2464939
Sirois MG and Edelman ER VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. 1997 Am. J. Physiol. pmid:9227554
Bellan JA et al. Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. 1992 Am. J. Physiol. pmid:1379004
Koyama S et al. Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. 1995 Am. J. Physiol. pmid:7631812
Wallace JL Lipid mediators of inflammation in gastric ulcer. 1990 Am. J. Physiol. pmid:2405704
Kruse-Elliott KT et al. Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. 1992 Am. J. Physiol. pmid:1415600