| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Hattar K et al. | Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. | 2001 | J. Immunol. | pmid:11342652 |
| Vittimberga FJ et al. | Endotoxin fails to stimulate inositol triphosphate production in macrophages. | 1999 | Int. J. Surg. Investig. | pmid:11341611 |
| Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
| Sugano T et al. | Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts. | 2001 | Mol. Hum. Reprod. | pmid:11331671 |
| Caplan MS et al. | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. | 2001 | Pediatr. Res. | pmid:11328947 |
| Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
| Alam N et al. | Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata. | 2001 | J. Nat. Prod. | pmid:11325244 |
| Yan GT et al. | [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. | 1998 | Sheng Li Xue Bao | pmid:11324524 |
| Yildirim G et al. | Does the platelet-activating factor affect the antioxidant defense system? The possible role of hyperbaric oxygenation. | 2000 | Biol Trace Elem Res | pmid:11318001 |
| Panayiotou A et al. | Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): correlation with platelet-activating factor and atherogenesis. | 2000 | J. Agric. Food Chem. | pmid:11312810 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Lukashova V et al. | G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. | 2001 | J. Biol. Chem. | pmid:11309383 |
| Dery RE et al. | Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). | 2001 Jan-Mar | Int. Arch. Allergy Immunol. | pmid:11306968 |
| Ishizuka S et al. | Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11306440 |
| Ilveskero S et al. | Procoagulant activity on platelets adhered to collagen or plasma clot. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304482 |
| Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
| Teather LA et al. | Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. | 2001 | Neurobiol Learn Mem | pmid:11300737 |
| Teeling JL et al. | Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model. | 2001 | Br. J. Haematol. | pmid:11298603 |
| Kuijpers TW et al. | The impact of platelet-activating factor (PAF)-like mediators on the functional activity of neutrophils: anti-inflammatory effects of human PAF-acetylhydrolase. | 2001 | Clin. Exp. Immunol. | pmid:11298128 |
| Richardson RM et al. | RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. | 2001 | Biochemistry | pmid:11297424 |
| Min JH et al. | Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | 2001 | Biochemistry | pmid:11294621 |
| Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
| Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Beales IL | Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. | 2001 | Dig. Dis. Sci. | pmid:11284466 |
| Ulrich CD | Lexipafant in severe acute pancreatitis: the final word? | 2001 | Curr Gastroenterol Rep | pmid:11276374 |
| Zeng S et al. | Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270998 |
| Gujrati VR and Sastry BV | Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001 | Life Sci. | pmid:11270625 |
| Iwazaki S et al. | FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. | 2001 Jan-Feb | Hepatogastroenterology | pmid:11268964 |
| Gu M et al. | Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 | J. Surg. Res. | pmid:11266278 |
| Chen YG et al. | Lignans from Kadsura angustifolia. | 1998 | J Asian Nat Prod Res | pmid:11261213 |
| Wittwer T et al. | Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11257563 |
| Denis MA et al. | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. | 2001 | Scand. J. Gastroenterol. | pmid:11252412 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Gandhi CR et al. | A23187 causes release of inositol phosphates from cultured rat Kupffer cells. | 2001 | Eur. J. Pharmacol. | pmid:11245846 |
| Bachert C | Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. | 2001 | Allergy | pmid:11243500 |
| Persidsky Y et al. | Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | 2001 | J. Neuroimmunol. | pmid:11240016 |
| Tokumura A et al. | Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. | 2000 | Biofactors | pmid:11237195 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
| Lash GE and Legge M | Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. | 2001 | Am. J. Reprod. Immunol. | pmid:11216875 |
| Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
| Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
| Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
| Mannori G et al. | Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. | 2000 | Clin. Exp. Metastasis | pmid:11206844 |
| Baker RR and Chang HY | The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. | 2000 | Mol. Cell. Biochem. | pmid:11204449 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Hauser CJ et al. | PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. | 2001 | J. Leukoc. Biol. | pmid:11200069 |
| Urasaki T et al. | Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. | 2001 | J. Leukoc. Biol. | pmid:11200053 |
| Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
| Kecskeméti V and Balogh I | The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. | 2000 | J. Physiol. Pharmacol. | pmid:11192945 |
| Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
| Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Zaitseva L et al. | Role of eicosanoids in regulation of macrophage phagocytic functions by platelet-activating factor during endotoxic shock. | 2000 | Bull. Exp. Biol. Med. | pmid:11177271 |
| Magai RM and Shukla SD | Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. | 2001 Jan-Feb | J. Biomed. Sci. | pmid:11173988 |
| Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
| Goudevenos J et al. | Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. | 2001 | Eur. J. Clin. Invest. | pmid:11168434 |
| Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
| Roudebush WE et al. | Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. | 2001 | Domest. Anim. Endocrinol. | pmid:11164329 |
| Stojanov T and O'Neill C | In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. | 2001 | Biol. Reprod. | pmid:11159375 |
| Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
| Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
| Rabinowitz SS et al. | Platelet-activating factor in infants at risk for necrotizing enterocolitis. | 2001 | J. Pediatr. | pmid:11148517 |
| Arese M et al. | HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. | 2001 | J. Immunol. | pmid:11145723 |
| Galimi F et al. | Hepatocyte growth factor is a regulator of monocyte-macrophage function. | 2001 | J. Immunol. | pmid:11145707 |
| Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Asimakopoulos G et al. | Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. | 2000 | Perfusion | pmid:11131212 |
| Adams JM et al. | G-protein receptor responses in trauma neutrophils. | 2000 | J Trauma | pmid:11130495 |
| Kelly RF | Current strategies in lung preservation. | 2000 | J. Lab. Clin. Med. | pmid:11128744 |
| Bussolati B et al. | IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). | 2000 | Clin. Exp. Immunol. | pmid:11122257 |
| Kaplan R et al. | Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. | 2000 | Br. J. Haematol. | pmid:11122160 |
| Hickey MJ et al. | L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo. | 2000 | J. Immunol. | pmid:11120848 |
| Iwamoto H et al. | Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. | 2000 | Transplant. Proc. | pmid:11119873 |
| Li N et al. | Platelet-leukocyte cross talk in whole blood. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116075 |
| Johnson CD et al. | Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. | 2001 | Gut | pmid:11115824 |
| Wechsung E and Houvenaghel A | Involvement of platelet activating factor in the endotoxin-induced effects on gastrointestinal electrical activity and some haematological parameters in the conscious miniature pig. | 2000 | J. Vet. Pharmacol. Ther. | pmid:11107007 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Chroni A and Mavri-Vavayanni M | Characterization of a platelet activating factor acetylhydrolase from rat adipocyte. | 2000 | Life Sci. | pmid:11105997 |
| Le Blanc K et al. | Defective platelet aggregation in polycythaemia vera is not caused by impaired calcium signaling, phospholipase D activation or decreased amounts of focal adhesion proteins. | 2000 | Eur. J. Haematol. | pmid:11092463 |
| Tanaka Y et al. | Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. | 2000 | Br. J. Pharmacol. | pmid:11082118 |
| Tjoelker LW and Stafforini DM | Platelet-activating factor acetylhydrolases in health and disease. | 2000 | Biochim. Biophys. Acta | pmid:11080681 |
| Alloatti G et al. | Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11080081 |
| Yoshimatsu Y et al. | Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells. | 2000 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:11074135 |
| Bussolati B et al. | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. | 2000 | Am. J. Pathol. | pmid:11073830 |
| Grassi S and Pettorossi VE | Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2000 | Neuroscience | pmid:11068144 |
| Okunuki H et al. | Induction of active systemic anaphylaxis by oral sensitization with ovalbumin in mast-cell-deficient mice. | 2000 | Immunol. Lett. | pmid:11064108 |
| Biancone L et al. | Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. | 2000 | Transplantation | pmid:11063341 |
| Bracco E et al. | Cell-cell signaling and adhesion in phagocytosis and early development of Dictyostelium. | 2000 | Int. J. Dev. Biol. | pmid:11061438 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
| Tiano L et al. | Oxidative response and membrane modification of diabetic platelets challenged with PAF. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060899 |
| Peri A et al. | Uteroglobin reverts the transformed phenotype in the endometrial adenocarcinoma cell line HEC-1A by disrupting the metabolic pathways generating platelet-activating factor. | 2000 | Int. J. Cancer | pmid:11058867 |
| Dichmann S et al. | Downregulation of platelet-activating factor responsiveness during maturation of human dendritic cells. | 2000 | J. Cell. Physiol. | pmid:11056009 |
| Chłopicki S et al. | Residual pulmonary neutrophils are involved in vaso- and bronchoconstrictor responses to platelet activating factor in the isolated buffer-perfused rat lung. | 2000 May-Jun | Pol J Pharmacol | pmid:11055579 |
| James JH and Fischer JE | Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? | 2000 | Shock | pmid:11049116 |
| Karlstad MD et al. | Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. | 2000 | Shock | pmid:11049115 |