Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Asphyxia Neonatorum D001238 4 associated lipids
Asthma D001249 52 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Brain Diseases D001927 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Zhao W et al. [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180114
Dong J et al. [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. 2005 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21171322
Liu SH et al. [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. 2009 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21189571
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Zhang J et al. [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11475720
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Yang AP and Chen Q [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21485072
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728