| MeSH term | MeSH ID | Detail |
|---|---|---|
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Bovine Virus Diarrhea-Mucosal Disease | D001912 | 2 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Wilson DV et al. | Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies. | 1994 | Am. J. Vet. Res. | pmid:8067617 |
| Dodam JR et al. | Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. | 1996 | Am. J. Vet. Res. | pmid:8712527 |
| Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
| Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
| Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
| Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
| Wilson DV and Stick JA | Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. | 1993 | Am. J. Vet. Res. | pmid:8498751 |
| Tan WC and Bethel RA | The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. | 1992 | Am. Rev. Respir. Dis. | pmid:1416419 |
| Symposium on The Clinical Importance of Leukotrienes and Platelet-activating Factor in Allergic Respiratory Diseases. November 14, 1990, San Francisco, California. | 1991 | Am. Rev. Respir. Dis. | pmid:1673326 | |
| Christman BW et al. | Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep. | 1990 | Am. Rev. Respir. Dis. | pmid:2174655 |
| Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
| Kohrogi H et al. | Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. | 1991 | Am. Rev. Respir. Dis. | pmid:1892304 |
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| Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
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| Oda M et al. | The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. | 1990 | Am. Rev. Respir. Dis. | pmid:2350088 |
| Nakajima H et al. | CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. | 1992 | Am. Rev. Respir. Dis. | pmid:1362635 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
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| Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
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| Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
| Horvath CJ et al. | Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. | 1991 | Am. Rev. Respir. Dis. | pmid:1741548 |
| Lantz RC et al. | The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin. | 1991 | Am. Rev. Respir. Dis. | pmid:2064124 |
| Arnoux B et al. | Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. | 1988 | Am. Rev. Respir. Dis. | pmid:3354991 |
| Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
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| Halonen M et al. | Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. | 1980 | Am. Rev. Respir. Dis. | pmid:7458063 |
| Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
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| Lansing MW et al. | Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. | 1991 | Am. Rev. Respir. Dis. | pmid:1741541 |
| Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
| Smith LJ et al. | Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. | 1993 | Am. Rev. Respir. Dis. | pmid:8368641 |
| Watson JW et al. | IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. | 1990 | Am. Rev. Respir. Dis. | pmid:2240832 |
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| Gulbenkian AR et al. | Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. | 1990 | Am. Rev. Respir. Dis. | pmid:2117872 |
| Tam FW et al. | Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. | 1992 | Am. Rev. Respir. Dis. | pmid:1416388 |
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| Lebedeva RN et al. | [The status of the receptor-controlled calcium metabolism of the thrombocytes in patients in the early postoperative period]. | 1991 Sep-Oct | Anesteziol Reanimatol | pmid:1767948 |
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