| MeSH term | MeSH ID | Detail |
|---|---|---|
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guinot P et al. | Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. | 1988 | Lancet | pmid:2898694 |
| Michel L et al. | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. | 1988 | J. Allergy Clin. Immunol. | pmid:2899102 |
| Michel L et al. | Release of PAF-acether and precursors during allergic cutaneous reactions. | 1988 | Lancet | pmid:2899817 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Fernandez-Gallardo S et al. | Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. | 1988 | Int. J. Immunopharmacol. | pmid:3139574 |
| Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
| Bratton DL et al. | Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. | 1988 | Biochim. Biophys. Acta | pmid:3370214 |
| Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
| Grue-Sørensen G et al. | Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. | 1988 | J. Med. Chem. | pmid:3373485 |
| Pirotzky E et al. | Protection of platelet-activating factor-induced acute renal failure by BN 52021. | 1988 | Br J Exp Pathol | pmid:3377967 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Wallace JL and MacNaughton WK | Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes. | 1988 | Eur. J. Pharmacol. | pmid:2843390 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
| Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
| Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
| Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
| Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. | 1988 | J. Allergy Clin. Immunol. | pmid:3403863 |
| Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
| Koenderman L et al. | An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals. | 1988 | J. Leukoc. Biol. | pmid:3404069 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. | 1988 | Br J Clin Pharmacol | pmid:3203062 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Leprevost C et al. | Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2971624 |
| Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
| Masugi F et al. | Platelet-activating factor and anti-platelet-aggregating factor in acute reduction of blood pressure following percutaneous transluminal renal angioplasty in patients with renovascular hypertension. | 1988 | J Hum Hypertens | pmid:2977405 |
| Danko G et al. | Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. | 1988 | Pharmacol Res Commun | pmid:3174804 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
| Andersson M and Pipkorn U | The effect of platelet activating factor on nasal hypersensitivity. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181276 |
| Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
| Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
| Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
| Whatley RE et al. | The regulation of synthesis of platelet-activating factor by endothelial cells. | 1988 | Chest | pmid:3342689 |
| Ukena D et al. | Radioligand binding of antagonists of platelet-activating factor to intact human platelets. | 1988 | FEBS Lett. | pmid:3342883 |
| Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
| Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
| Hsueh W et al. | Sequential release of leukotrienes and norepinephrine in rat bowel after platelet-activating factor. A mechanistic study of platelet-activating factor-induced bowel necrosis. | 1988 | Gastroenterology | pmid:3360262 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
| 17th annual UCLA symposium. Abstracts: Cell activation and signal initiation: receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production. | 1988 | J. Cell. Biochem. Suppl. | pmid:2835556 | |
| Paulson SK and Nicholson NS | A radioreceptor binding assay for measurement of platelet-activating factor synthesis by human neutrophils. | 1988 | J. Immunol. Methods | pmid:2837517 |
| Garcia JG et al. | Effect of platelet activating factor on leukocyte-endothelial cell interactions. | 1988 | Thromb. Res. | pmid:2842887 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
| Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
| Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
| Royall JA and Levin DL | Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury. | 1988 | J. Pediatr. | pmid:3276861 |
| Vanhoutte PM | Platelets, endothelium and blood vessel wall. | 1988 | Experientia | pmid:3278917 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Ghigo D et al. | Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. | 1988 | J. Biol. Chem. | pmid:2848827 |
| Aratani H et al. | Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. | 1988 | Jpn. J. Pharmacol. | pmid:2848961 |
| Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
| Stewart AG and Dusting GJ | Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages. | 1988 | Br. J. Pharmacol. | pmid:2850058 |
| Korth R et al. | Comparison of three paf-acether receptor antagonist ginkgolides. | 1988 | Eur. J. Pharmacol. | pmid:2850196 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |
| Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
| Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
| Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
| Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
| Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
| Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
| Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
| Chao W et al. | Identification of receptors for platelet-activating factor in rat Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2547767 |
| Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
| Kadiri C et al. | Phospholipase A2-mediated release of arachidonic acid in stimulated guinea pig alveolar macrophages: interaction with lipid mediators and cyclic AMP. | 1989 | J. Cell. Biochem. | pmid:2549080 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Pons L et al. | Involvement of platelet-activating factor (PAF) in endotoxin-induced intestinal motor disturbances in rats. | 1989 | Life Sci. | pmid:2570338 |
| Shigenobu K et al. | Platelet-activating factor: lack of direct action on guinea pig myocardium and possible transmitter release from cardiac sympathetic nerve endings at high concentrations. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2570630 |
| Flüge T et al. | [The significance of endocrine, neurocrine and paracrine mediators in the regulation of bronchial reactivity]. | 1989 | Pneumologie | pmid:2685801 |
| Dulioust A et al. | Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages. | 1989 | Biochem. J. | pmid:2513801 |
| Stoll LL et al. | 1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells. | 1989 | Cell Regul. | pmid:2519612 |
| Teh BS et al. | Suppression by tetrandrine of human platelet aggregation induced by platelet-activating factor and other stimulants. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2785965 |
| Domingo MT et al. | Characterization of specific binding sites for PAF in the iris and ciliary body of rabbit. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2540746 |
| Tanaka M et al. | Regulation of Fc epsilon receptor 2 (CD23) expression on a human eosinophilic cell line EoL3 and a human monocytic cell line U937 by transforming growth factor beta. | 1989 | Cell. Immunol. | pmid:2526691 |
| Glusa E et al. | Verapamil is a potent inhibitor of 5-HT-induced platelet aggregation. | 1989 | Thromb. Res. | pmid:2528843 |
| Stahl GL et al. | Protective effects of a specific platelet activating factor (PAF) antagonist, WEB 2086, in traumatic shock. | 1989 | Thromb. Res. | pmid:2718150 |
| Barer GR et al. | Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. | 1989 | Am. Rev. Respir. Dis. | pmid:2817616 |
| Lagente V et al. | Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2645865 |
| Morley J et al. | Platelet activating factor and airway smooth muscle. | 1989 | Pharmacol. Ther. | pmid:2646651 |
| Wong T et al. | Platelet size affects both micro- and macro-aggregation: contributions of platelet number, volume fraction and cell surface. | 1989 | Thromb. Haemost. | pmid:2683192 |
| Page CP and Spina D | The therapeutic relevance of PAF antagonists. | 1989 | Agents Actions Suppl. | pmid:2683635 |
| Svetlov SI et al. | [A morphologic analysis of changes in the lungs and kidneys caused by acetyl glyceryl ether phosphorylcholine and limited by verapamil]. | 1989 | Biull Eksp Biol Med | pmid:2611382 |
| Kamata K et al. | Endothelium-dependent vasodilator effects of platelet activating factor on rat resistance vessels. | 1989 | Br. J. Pharmacol. | pmid:2611496 |
| De Vos C et al. | Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2523357 |
| Hemmendinger S et al. | Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. | 1989 | J. Allergy Clin. Immunol. | pmid:2523922 |
| Pinto A et al. | Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat. | 1989 | Br. J. Pharmacol. | pmid:2743081 |
| Schlondorff D et al. | Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. | 1989 | Am. J. Physiol. | pmid:2492160 |
| Shattil SJ et al. | Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. | 1989 | Blood | pmid:2535942 |