| MeSH term | MeSH ID | Detail |
|---|---|---|
| Burns | D002056 | 34 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hillmar I et al. | Effects of a thio analog of platelet-activating factor on platelet aggregation and adenosine 3',5'-monophosphate concentration in hepatocyte suspensions and in platelets. A comparison with the naturally occurring compound. | 1984 | Hoppe-Seyler's Z. Physiol. Chem. | pmid:6325321 |
| Valone FH | Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1984 | Immunology | pmid:6325330 |
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Kulikov VI and Bergel'son LD | [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. | 1984 | Biokhimiia | pmid:6093897 |
| Haye B et al. | Interactions between thyreostimulin and PAF-acether on thyroid cell metabolism. | 1984 | Eur. J. Pharmacol. | pmid:6094205 |
| Gordeev KIu et al. | [A bioregulator of lipid nature--a platelet activating factor (PAF)]. | 1984 | Bioorg. Khim. | pmid:6099122 |
| Wang ZY | [Advances in the physiopathology of platelets]. | 1984 | Zhonghua Nei Ke Za Zhi | pmid:6099795 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Nishihira J et al. | Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid). | 1984 | J. Biochem. | pmid:6430883 |
| Feuerstein G et al. | Hypotension produced by platelet-activating factor is reversed by thyrotropin-releasing hormone. | 1984 | Circ. Shock | pmid:6432359 |
| Parnham MJ et al. | Regulation of the oxidative burst of macrophages by lipid mediators. | 1984 | Agents Actions Suppl. | pmid:6433680 |
| O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Nishizawa EE and Della-Coletta AA | The formation of a thrombin-like material (TLM) following stimulation of leukocytes. | 1984 | Thromb. Res. | pmid:6484896 |
| Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
| Nakamura N et al. | Synthesis and biological activities of bioisosteric O-carba-analogues of platelet activating factor (PAF). | 1984 | Chem. Pharm. Bull. | pmid:6488414 |
| Sakamoto H et al. | Stimulation of leukocyte phagocytic activity by the platelet release reaction. | 1984 | Pathology | pmid:6462776 |
| Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
| Williams KA and Haslam RJ | Effects of NaCl and GTP on the inhibition of platelet adenylate cyclase by 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic platelet-activating factor). | 1984 | Biochim. Biophys. Acta | pmid:6696908 |
| Hoffman DR et al. | Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. | 1984 | Blood | pmid:6696992 |
| Basran GS et al. | Platelet-activating factor: a possible mediator of the dual response to allergen? | 1984 | Clin. Allergy | pmid:6697475 |
| Kelton JG et al. | Clinical usefulness of testing for a heparin-dependent platelet-aggregating factor in patients with suspected heparin-associated thrombocytopenia. | 1984 | J. Lab. Clin. Med. | pmid:6699475 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| El Tamer A et al. | Studies on ether phospholipids. I. A new method of determination using phospholipase A1 from guinea pig pancreas: application to Krebs II ascites cells. | 1984 | Biochim. Biophys. Acta | pmid:6712966 |
| Touqui L et al. | Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets. | 1984 | Experientia | pmid:6714369 |
| Masugi F et al. | [Etiological studies of hypertension. G. APRL (antihypertensive polar renomedullary lipid)]. | 1984 | Nippon Rinsho | pmid:6716685 |
| Kester M et al. | The potentiation of arterial contraction with platelet activating factor. | 1984 | Pflugers Arch. | pmid:6718228 |
| Kramer RM et al. | Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | 1984 | J. Biol. Chem. | pmid:6436245 |
| Archer CB et al. | Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin. | 1984 | Br. J. Dermatol. | pmid:6581831 |
| Andreesen R et al. | Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine. | 1984 | J. Natl. Cancer Inst. | pmid:6582303 |
| Prescott SM et al. | Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6587368 |
| Iñarrea P et al. | Characteristics of the binding of platelet-activating factor to platelets of different animal species. | 1984 | Eur. J. Pharmacol. | pmid:6510472 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
| Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
| Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
| Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
| Page CP et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857401 |
| Gresele P et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857402 |
| Lenihan DJ et al. | Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. | 1985 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2861063 |
| Braquet P et al. | Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021. | 1985 | Lancet | pmid:2861423 |
| McIntyre TM et al. | Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. | 1985 | J. Clin. Invest. | pmid:2862164 |
| Archer CB et al. | Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. | 1985 | Br. J. Pharmacol. | pmid:2862936 |
| Morris HG | Mechanisms of glucocorticoid action in pulmonary disease. | 1985 | Chest | pmid:2410202 |
| Bruynzeel PL et al. | Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. | 1985 | FEBS Lett. | pmid:2995125 |
| Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
| Sturk A et al. | Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. | 1985 | Thromb. Res. | pmid:2934863 |
| Morley J et al. | Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:3924841 |
| Hwang SB et al. | Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. | 1985 | Lab. Invest. | pmid:3925239 |
| Valone FH and Johnson B | Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1985 | J. Immunol. | pmid:2578151 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Ribbes G et al. | Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. | 1985 | FEBS Lett. | pmid:3932094 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| Barnes PJ | Mediators and asthma. | 1985 | Br J Hosp Med | pmid:3936563 |
| Hemmendinger S et al. | [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. | 1985 | Arch Mal Coeur Vaiss | pmid:3938941 |
| Iñarrea P et al. | Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. | 1985 | Immunopharmacology | pmid:3886598 |
| Lellouch-Tubiana A et al. | Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. | 1985 | Br J Exp Pathol | pmid:3890915 |
| Weber N and Mangold HK | Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. | 1985 | J. Lipid Res. | pmid:3891896 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
| Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
| Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
| Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
| Parente L and Flower RJ | Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. | 1985 | Life Sci. | pmid:3838566 |
| Kumar R et al. | Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. | 1985 | Biochim. Biophys. Acta | pmid:3839684 |
| Tokumura A and Tsukatani H | [Antagonists of platelet activating factor]. | 1985 | Seikagaku | pmid:3009656 |
| MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
| Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
| Teng CM et al. | Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. | 1985 | Biochim. Biophys. Acta | pmid:3926005 |
| Ostermann G et al. | Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. | 1985 | Biomed. Biochim. Acta | pmid:4004829 |
| Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Detsouli A et al. | Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. | 1985 | Br. J. Pharmacol. | pmid:4005486 |
| Korth R et al. | Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. | 1985 | Chem. Phys. Lipids | pmid:4006034 |
| Verstraete M et al. | An overview of antiplatelet and antithrombotic drugs. | 1985 | Haemostasis | pmid:3159632 |
| Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
| Zimmerman GA et al. | Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. | 1985 | Circulation | pmid:3928193 |
| Benveniste J and Chignard M | A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? | 1985 | Circulation | pmid:3928192 |
| Cordón-Cardó C | [The barley cell or mastocyte: cellular and molecular biology]. | 1985 | Med Clin (Barc) | pmid:2580196 |
| Disselnkötter H et al. | [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. | 1985 | Arch. Pharm. (Weinheim) | pmid:4051690 |
| Ogunbiyi PO and Eyre P | Pharmacological studies of pulmonary anaphylaxis in vitro: a review. | 1985 | Agents Actions | pmid:2420161 |
| Robinson M and Snyder F | Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. | 1985 | Biochim. Biophys. Acta | pmid:4052436 |
| Kozlov VK et al. | [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. | 1985 | Biull Eksp Biol Med | pmid:4052603 |
| Page CP et al. | Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. | 1985 | Int J Tissue React | pmid:4055261 |
| Wardlow ML | Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. | 1985 | J. Chromatogr. | pmid:4055961 |
| Hubbard JW et al. | Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. | 1985 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:4059660 |
| Imbs AB et al. | [Synthesis of a fluorescently-labeled platelet activating factor]. | 1985 | Bioorg. Khim. | pmid:4062993 |
| Tokumura A et al. | Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. | 1985 | J. Chromatogr. | pmid:4066848 |
| Meloni Bruneri LH and Barbieri D | [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. | 1985 | Sangre (Barc) | pmid:4071355 |
| Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
| Mushayakarara EC and Mantsch HH | Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4075223 |
| Vanhoutte PM and Houston DS | Platelets, endothelium, and vasospasm. | 1985 | Circulation | pmid:3861273 |
| Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
| Morley J et al. | PAF and airway hyperreactivity. | 1985 | Lancet | pmid:2863479 |
| Morley J et al. | Platelets in asthma. | 1985 | Lancet | pmid:2863708 |
| Cox CP | Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). | 1985 | Comp Biochem Physiol A Comp Physiol | pmid:2864195 |