Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Borgquist JD et al. | Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. | 2002 | J. Leukoc. Biol. | pmid:11994500 |
Kalkanci A et al. | The role of tumour necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) interaction on murine candidosis. | 2002 | Mycoses | pmid:12000505 |
McManus LM and Pinckard RN | PAF, a putative mediator of oral inflammation. | 2000 | Crit. Rev. Oral Biol. Med. | pmid:12002818 |
Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
Zimmerman GA et al. | The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. | 2002 | Crit. Care Med. | pmid:12004251 |
Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
Zhang J et al. | Effect of buyang huanwu decoction on platelet activating factor content in arterial blood pre- and post-arterial thrombosis in rats. | 2001 | J Tradit Chin Med | pmid:12014136 |
Ottino P et al. | Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. | 2002 | Exp. Eye Res. | pmid:12014920 |
Michalis LK et al. | Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. | 2002 | Curr Med Res Opin | pmid:12017208 |
Iatrou C et al. | Is platelet-activating factor produced during hemodialysis with AN-69 polyacrylonitrile membrane? | 2002 | Nephron | pmid:12021524 |
Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
Honda Z et al. | Platelet-activating factor receptor. | 2002 | J. Biochem. | pmid:12038971 |
Lloberas N et al. | Postischemic renal oxidative stress induces inflammatory response through PAF and oxidized phospholipids. Prevention by antioxidant treatment. | 2002 | FASEB J. | pmid:12039876 |
Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
Nakamura T et al. | Relationship between the platelet activating factor acetylhydrolase gene and intractability of ulcerative colitis. | 2002 | Dis. Colon Rectum | pmid:12068200 |
Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
Jaracz S et al. | Ginkgolides: selective acetylations, translactonization, and biological evaluation. | 2002 | J. Org. Chem. | pmid:12076171 |
Downing SJ et al. | Effect of inflammatory mediators on the physiology of the human Fallopian tube. | 2002 | Hum Fertil (Camb) | pmid:12082208 |
Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
Mohr PJ and Halcomb RL | Convergent enantioselective synthesis of the tricyclic core of phomactin A. | 2002 | Org. Lett. | pmid:12098260 |
Yoshida H et al. | Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. | 2002 | Brain Res. | pmid:12106666 |
Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
Parker MA et al. | Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | 2002 | J. Neurosci. Res. | pmid:12111814 |
Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
Sun Z et al. | Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. | 2002 | J. Surg. Res. | pmid:12121711 |
Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
Giorgi G et al. | Mass spectrometric characterization of substituted 2-thiazolin-4-one derivatives. | 2002 | J Mass Spectrom | pmid:12125004 |
Benveniste J et al. | [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. | 1979 | C. R. Acad. Sci., D, Sci. Nat. | pmid:121258 |
Kulikov VI and Muzya GI | Influence of platelet-activating factor, its cell analogs, and antagonist on the production of superoxide radicals by blood leukocytes of healthy and hypercholesterolemic individuals. | 2002 | Biochemistry Mosc. | pmid:12126473 |
Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
Teather LA et al. | Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures. | 2002 | Brain Res. | pmid:12133598 |
Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
Bazan NG et al. | What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. | 2002 | Prog. Brain Res. | pmid:12143339 |
McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
De Plaen IG et al. | Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. | 2002 | Immunology | pmid:12153521 |
Fonteh AN | Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. | 2002 | Eur. J. Biochem. | pmid:12153573 |
Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
Ryan KL et al. | Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12168504 |
Takizawa T et al. | Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. | 2002 | J. Allergy Clin. Immunol. | pmid:12170264 |
Sakai H et al. | Nitric oxide-induced Cl- secretion in isolated rat colon is mediated by the release of thromboxane A2. | 2002 | J. Physiol. (Lond.) | pmid:12181297 |