Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Thalassemia D013789 8 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Toxemia D014115 3 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Uremia D014511 33 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Viremia D014766 4 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Wounds and Injuries D014947 20 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
HIV Infections D015658 20 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Helicobacter Infections D016481 21 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Liver Failure D017093 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Strongylida Infections D017206 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Page CP et al. Platelets and asthma. 1985 Lancet pmid:2857401
Gresele P et al. Platelets and asthma. 1985 Lancet pmid:2857402
Lenihan DJ et al. Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. 1985 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2861063
Braquet P et al. Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021. 1985 Lancet pmid:2861423
Matsumoto M and Miwa M Platelet-activating factor-binding protein in human serum. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004155
McIntyre TM et al. Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. 1985 J. Clin. Invest. pmid:2862164
Terashita Z et al. Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004156
Morris HG Mechanisms of glucocorticoid action in pulmonary disease. 1985 Chest pmid:2410202
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Harlan JM Leukocyte-endothelial interactions. 1985 Blood pmid:3918593
McKean ML and Silver MJ Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. 1985 Biochem. J. pmid:3919710
Bruynzeel PL et al. Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. 1985 FEBS Lett. pmid:2995125
Archer CB et al. Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. 1985 Agents Actions pmid:3923788
Morley J et al. Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. 1985 Int. Arch. Allergy Appl. Immunol. pmid:3924841
Hwang SB et al. Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. 1985 Lab. Invest. pmid:3925239
Valone FH and Johnson B Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. 1985 J. Immunol. pmid:2578151
Bourgain RH et al. The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. 1985 Prostaglandins pmid:3931178
Ribbes G et al. Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. 1985 FEBS Lett. pmid:3932094
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Barnes PJ Mediators and asthma. 1985 Br J Hosp Med pmid:3936563
Benveniste J Biosynthesis and function of PAF-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936197
Waku K et al. Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936199
Saito K et al. Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936200
Hanahan DJ et al. Platelet-activating factor: a unique lipid chemical mediator. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936201
Inoue K et al. Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936203
Touqui L et al. Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. 1985 Biochem. J. pmid:4052028
Benveniste J Paf-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3159192
Verstraete M et al. An overview of antiplatelet and antithrombotic drugs. 1985 Haemostasis pmid:3159632
Apprill P et al. Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. 1985 Circulation pmid:2988822
Zimmerman GA et al. Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. 1985 Circulation pmid:3928193
Gerdin B et al. Permeability-increasing ability of PAF-acether in rat skin. 1985 Inflammation pmid:3980073
Emeis JJ and Kluft C PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. 1985 Blood pmid:3924144
Benveniste J and Chignard M A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? 1985 Circulation pmid:3928192
Cordón-Cardó C [The barley cell or mastocyte: cellular and molecular biology]. 1985 Med Clin (Barc) pmid:2580196
Klöcking HP et al. Release of tissue-type plasminogen activator by platelet-activating factor. 1985 Thromb. Res. pmid:4040278
McManus LM and Pinckard RN Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. 1985 Am. J. Pathol. pmid:4050977
Disselnkötter H et al. [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. 1985 Arch. Pharm. (Weinheim) pmid:4051690
Ogunbiyi PO and Eyre P Pharmacological studies of pulmonary anaphylaxis in vitro: a review. 1985 Agents Actions pmid:2420161
Robinson M and Snyder F Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. 1985 Biochim. Biophys. Acta pmid:4052436
Kozlov VK et al. [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. 1985 Biull Eksp Biol Med pmid:4052603
Page CP et al. Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. 1985 Int J Tissue React pmid:4055261
Wardlow ML Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. 1985 J. Chromatogr. pmid:4055961
Hubbard JW et al. Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. 1985 Res. Commun. Chem. Pathol. Pharmacol. pmid:4059660
Vanhoutte PM and Houston DS Platelets, endothelium, and vasospasm. 1985 Circulation pmid:3861273
Sandler RM et al. Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. 1985 Am. J. Clin. Pathol. pmid:4003343
Tencé M et al. Ether-phospholipid composition in neutrophils and platelets. 1985 Thromb. Res. pmid:4024039
Tan EL and Snyder F Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. 1985 Thromb. Res. pmid:4024051
Weisman SM et al. Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. 1985 J. Pharmacol. Exp. Ther. pmid:3862805
Leclercq M et al. [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. 1985 Rev Med Liege pmid:2418479
Pipili E Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. 1985 Thromb. Haemost. pmid:2418525