Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Thalassemia D013789 8 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Toxemia D014115 3 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Uremia D014511 33 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Viremia D014766 4 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Wounds and Injuries D014947 20 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
HIV Infections D015658 20 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Helicobacter Infections D016481 21 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Liver Failure D017093 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Strongylida Infections D017206 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Matsumoto M and Miwa M Platelet-activating factor-binding protein in human serum. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004155
Terashita Z et al. Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004156
Barnes JL and Venkatachalam MA The role of platelets and polycationic mediators in glomerular vascular injury. 1985 Semin. Nephrol. pmid:2957770
Leid RW and Potter KA Inflammation and mediators of lung injury. 1985 Vet. Clin. North Am. Food Anim. Pract. pmid:3907779
Shukla SD Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. 1985 Arch. Biochem. Biophys. pmid:3875314
Roubin R and Benveniste J Formation of prostaglandins, leukotrienes and paf-acether by macrophages. 1985 Comp. Immunol. Microbiol. Infect. Dis. pmid:3910339
Wasserman SI Mast cell mediators in the blood of patients with asthma. 1985 Chest pmid:3880526
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Sybertz EJ et al. Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. 1985 J. Pharmacol. Exp. Ther. pmid:3917504
Harlan JM Leukocyte-endothelial interactions. 1985 Blood pmid:3918593
McKean ML and Silver MJ Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. 1985 Biochem. J. pmid:3919710
Moore TL and Weiss TD Mediators of inflammation. 1985 Semin. Arthritis Rheum. pmid:3936177
Archer CB et al. Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. 1985 Agents Actions pmid:3923788
Morley J et al. Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. 1985 Int. Arch. Allergy Appl. Immunol. pmid:3924841
Juhan-Vague I et al. Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. 1985 Thromb. Res. pmid:3923649
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Camussi G et al. The role of platelet-activating factor in experimental immune complex pathology. 1985 Int J Tissue React pmid:2932406
Benveniste J Biosynthesis and function of PAF-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936197
Waku K et al. Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936199
Billah MM et al. Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. 1985 J. Biol. Chem. pmid:3922982
Chesney CM et al. Desensitization of human platelets by platelet activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:3977920
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Archer CB et al. Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. 1985 Br. J. Dermatol. pmid:3978036
Gerdin B et al. Permeability-increasing ability of PAF-acether in rat skin. 1985 Inflammation pmid:3980073
Emeis JJ and Kluft C PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. 1985 Blood pmid:3924144
Yousufzai SY and Abdel-Latif AA Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. 1985 Biochem. J. pmid:3927898
Aul C et al. [Thrombotic thrombocytopenic purpura]. 1985 Klin. Wochenschr. pmid:4038757
Atkins JN Platelet-aggregating factor in thrombotic thrombocytopenic purpura. 1985 Ann. Intern. Med. pmid:4038861
Klöcking HP et al. Release of tissue-type plasminogen activator by platelet-activating factor. 1985 Thromb. Res. pmid:4040278
McManus LM and Pinckard RN Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. 1985 Am. J. Pathol. pmid:4050977
Disselnkötter H et al. [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. 1985 Arch. Pharm. (Weinheim) pmid:4051690
Page CP et al. Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. 1985 Agents Actions pmid:4003195
Page CP et al. Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. 1985 Agents Actions pmid:4003196
Spicer BA et al. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. 1985 Agents Actions pmid:4003197
Sandler RM et al. Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. 1985 Am. J. Clin. Pathol. pmid:4003343
Tencé M et al. Ether-phospholipid composition in neutrophils and platelets. 1985 Thromb. Res. pmid:4024039
Tan EL and Snyder F Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. 1985 Thromb. Res. pmid:4024051
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Peach MJ et al. Mechanisms of endothelium-dependent vascular smooth muscle relaxation. 1985 Biochem. Pharmacol. pmid:2988558
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Johnson HM and Torres BA Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2412225
Fjellner B and Hägermark O Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. 1985 Acta Derm. Venereol. pmid:2416164
Shen TY et al. Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2983307
Avdonin PV and Altukhova IP [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. 1985 Biokhimiia pmid:2416359
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Avdonin PV et al. [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. 1985 Biokhimiia pmid:3000463
Lee TD et al. Heterogeneity in mast cell populations. 1985 Clin Immunol Rev pmid:2417770
Leclercq M et al. [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. 1985 Rev Med Liege pmid:2418479
Pipili E Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. 1985 Thromb. Haemost. pmid:2418525
Nishihira J et al. Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. 1985 Tohoku J. Exp. Med. pmid:3001971