Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Thalassemia D013789 8 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Toxemia D014115 3 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Uremia D014511 33 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Viremia D014766 4 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Wounds and Injuries D014947 20 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
HIV Infections D015658 20 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Helicobacter Infections D016481 21 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Liver Failure D017093 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Strongylida Infections D017206 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Schaefer MB et al. Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. 2008 Eur. Respir. J. pmid:18653653
Samanta U and Bahnson BJ Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. 2008 J. Biol. Chem. pmid:18784071
Beuk RJ et al. Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. 2008 Br J Surg pmid:18720462
Konger RL et al. Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. 2008 Prostaglandins Other Lipid Mediat. pmid:18555720
Kuliszkiewicz-Janus M et al. Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. 2008 Cell. Mol. Biol. Lett. pmid:17952375
Leong HS et al. Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. 2008 J. Leukoc. Biol. pmid:17974709
Adamson RH et al. Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18178724
Gountopoulou A et al. TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. 2008 Cytokine pmid:18180165
Kwasniewski FH et al. Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. 2008 Int. Immunopharmacol. pmid:18182253
Chen Y et al. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. 2008 World J. Gastroenterol. pmid:18186558
Hikiji H et al. The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. 2008 Prog. Lipid Res. pmid:18187046
Zhang Q et al. UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. 2008 J. Invest. Dermatol. pmid:18200048
Lu YY et al. Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. 2008 World J. Gastroenterol. pmid:18205269
Harayama T et al. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. 2008 J. Biol. Chem. pmid:18285344
Mizutani T et al. Genuine functions of P-glycoprotein (ABCB1). 2008 Curr. Drug Metab. pmid:18288958
Fukunaga A et al. Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. 2008 J. Immunol. pmid:18292528
van Zoelen MA et al. Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. 2008 J. Immunol. pmid:18292561
Knapp S et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. 2008 J. Immunol. pmid:18292574
Mullol J et al. Rupatadine in allergic rhinitis and chronic urticaria. 2008 Allergy pmid:18339040
Claud EC et al. Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18339705
Shindou H [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. 2008 Seikagaku pmid:18341030
McLaughlin NJ et al. Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. 2008 J. Immunol. pmid:18523285
Felfernig M et al. Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. 2008 J R Nav Med Serv pmid:18524134
Tsoupras AB et al. Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? 2008 AIDS Res. Hum. Retroviruses pmid:18620493
Corl CM et al. Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. 2008 J. Dairy Sci. pmid:18650283
Landgraf RG et al. Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17923399
Vadnais ML et al. Current concepts of molecular events during bovine and porcine spermatozoa capacitation. 2007 May-Jun Arch. Androl. pmid:17612869
Rosenwasser L New insights into the pathophysiology of allergic rhinitis. 2007 Jan-Feb Allergy Asthma Proc pmid:17390750
Boetkjaer A et al. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. 2007 Neurosci. Lett. pmid:17881124
Xu W et al. Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. 2007 Chin. Med. J. pmid:18028783
Keam SJ and Plosker GL Rupatadine: a review of its use in the management of allergic disorders. 2007 Drugs pmid:17335300
Van Overloop H et al. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. 2007 Biol. Chem. pmid:17338639
Cui S et al. L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17395449
Roudebush WE Seminal platelet-activating factor. 2007 Semin. Thromb. Hemost. pmid:17253192
Souza LJ et al. Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. 2007 Pancreatology pmid:17449968
Shin CR et al. Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. 2007 J. Periodont. Res. pmid:17451539
Truffinet V et al. No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. 2007 Leuk. Res. pmid:17350684
Paterson WG et al. Role of platelet-activating factor in acid-induced esophageal mucosal injury. 2007 Dig. Dis. Sci. pmid:17415649
Tsimikas S et al. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17626905
Li Y et al. Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. 2007 Biol. Reprod. pmid:17634444
Nagi-Miura N et al. Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. 2007 Biol. Pharm. Bull. pmid:17603181
Wang J et al. Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. 2007 Int. J. Cardiol. pmid:16887214
Tsantila N et al. Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. 2007 Mediators Inflamm. pmid:18253466
Takahashi T et al. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. 2007 Microvasc. Res. pmid:17027041
Ko HM et al. Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. 2007 Int. J. Cancer pmid:17187368
Bate C et al. Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. 2007 J Neuroinflammation pmid:17233902
Caini P et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. 2007 J. Viral Hepat. pmid:17212640
Callender HL et al. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. 2007 Anal. Chem. pmid:17194150
Heusler P and Boehmer G Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. 2007 Brain Res. pmid:17196945
Fragopoulou E et al. Biological activity of acetylated phenolic compounds. 2007 J. Agric. Food Chem. pmid:17199317