Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Thalassemia D013789 8 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thrombocytosis D013922 4 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Toxemia D014115 3 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Uremia D014511 33 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Viremia D014766 4 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Wounds and Injuries D014947 20 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
HIV Infections D015658 20 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Helicobacter Infections D016481 21 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Liver Failure D017093 5 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Strongylida Infections D017206 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Pelvic Pain D017699 7 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Leukostasis D018921 1 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Endotoxemia D019446 27 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Thrombophilia D019851 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Venous Thrombosis D020246 11 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Stroke D020521 32 associated lipids
Fetal Weight D020567 12 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Coronary Stenosis D023921 6 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hyperuricemia D033461 4 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kang LP et al. Steroidal saponins from Tribulus terrestris. 2014 Phytochemistry pmid:25172515
Wu KZ et al. Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. 2014 Interdiscip Sci pmid:25172450
Nitoda E et al. Correlation of platelet activating factor and age-related macular degeneration. 2014 Expert Opin. Ther. Targets pmid:25077601
Sirangelo I et al. Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. 2014 J. Cell. Biochem. pmid:25053109
Xanthopoulou MN et al. Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. 2014 Food Chem pmid:25038648
Reyes-Quiroz ME et al. Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. 2014 FEBS J. pmid:24289152
Semini G et al. Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. 2014 Biochem. Pharmacol. pmid:24291779
Gazos-Lopes F et al. Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. 2014 PLoS Negl Trop Dis pmid:25101628
Morimoto R et al. Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. 2014 J. Biol. Chem. pmid:24742674
Summers C et al. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. 2014 Thorax pmid:24706039
Yang Y et al. Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. 2014 Eur. J. Immunol. pmid:24777913
Frazer CA Heparin-induced thrombocytopenia. 2013 Nov-Dec Medsurg Nurs pmid:24600938
Muñoz-Cano R et al. Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. 2013 Mar-Apr Am J Rhinol Allergy pmid:23562190
Watschinger K and Werner ER Orphan enzymes in ether lipid metabolism. 2013 Biochimie pmid:22771767
Nasopoulou C et al. Hen egg yolk lipid fractions with antiatherogenic properties. 2013 Anim. Sci. J. pmid:23480708
Sato A et al. An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. 2013 Eur. J. Pharmacol. pmid:23792041
Ayaz G et al. The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. 2013 Gene pmid:23816407
Yamazaki Y et al. A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. 2013 Biochem. Pharmacol. pmid:23817078
Xia SH et al. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. 2013 World J. Gastroenterol. pmid:23840141
Mazereeuw G et al. Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. 2013 Neurosci Biobehav Rev pmid:23800745
Wang C et al. Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. 2013 Lipids Health Dis pmid:23805935
Nettis E et al. Rupatadine for the treatment of urticaria. 2013 Expert Opin Pharmacother pmid:23806068
Sato A and Ebina K [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. 2013 Seikagaku pmid:23819394
Compalati E and Canonica GW Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. 2013 Curr Med Res Opin pmid:23826741
Xu H et al. Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. 2013 FEBS J. pmid:23826908
Liu G et al. Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. 2013 Infect. Immun. pmid:23774595
Tokuoka SM et al. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23743196
Stanca E et al. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin. 2013 Biochim. Biophys. Acta pmid:23851051
Nagase T [Respiratory failure]. 2013 Nippon Rinsho pmid:23855209
Krause K et al. Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. 2013 Allergy pmid:23320562
Vanstreels L and Merk HF [Value of in-vitro diagnostic tools after anaphylaxis]. 2013 Hautarzt pmid:23385619
Sato A and Ebina K Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. 2013 Inflamm. Res. pmid:23370722
Singh P et al. Platelet-activating factor (PAF)-antagonists of natural origin. 2013 Fitoterapia pmid:23160091
Costa M et al. Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. 2013 Stem Cell Res pmid:23164599
Sirangelo I et al. Amyloid toxicity and platelet-activating factor signaling. 2013 J. Cell. Physiol. pmid:23169529
Murakami M and Lambeau G Emerging roles of secreted phospholipase A(2) enzymes: an update. 2013 Biochimie pmid:23022039
Vadas P et al. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. 2013 J. Allergy Clin. Immunol. pmid:23040367
Kawano DF and Carvalho I Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. 2013 Mini Rev Med Chem pmid:23544467
Wei JF et al. Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. 2013 Biomed Res Int pmid:23509689
Forsman H et al. Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. 2013 PLoS ONE pmid:23555913
Borthakur A et al. Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. 2013 PLoS ONE pmid:24130731
Predescu S et al. Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. 2013 PLoS ONE pmid:24086643
Sahu RP et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. 2013 J. Immunol. pmid:23355733
Berman B and Cockerell CJ Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. 2013 J. Am. Acad. Dermatol. pmid:23228301
Frost BL and Caplan MS Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. 2013 Semin. Pediatr. Surg. pmid:23611612
Renteria LS et al. RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. 2013 Cell Prolif. pmid:24033386
Verouti SN et al. Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. 2013 Int J Artif Organs pmid:23335378
Zhao C et al. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. 2013 PLoS ONE pmid:24367540
Barbier M et al. Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. 2013 MBio pmid:23653444
Kim YH et al. PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway. 2013 J. Lipid Res. pmid:23911909