Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
| Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
| Bolin RW et al. | Lung endothelial and epithelial permeability after platelet-activating factor. | 1987 | J. Appl. Physiol. | pmid:3693212 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3694533 |
| Nomura H | Biological action and structural specificity of diacylglycerol in platelet activation. | 1987 | Kobe J Med Sci | pmid:3695296 |
| Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
| McFall TL et al. | Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. | 1987 | Pediatr. Res. | pmid:3037472 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
| Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
| Davenas E et al. | Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. | 1987 | Eur. J. Pharmacol. | pmid:3034632 |
| Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
| Kawasaki T and Snyder F | The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. | 1987 | Biochim. Biophys. Acta | pmid:3036238 |
| Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
| Shukla SD et al. | Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate. | 1987 | Biochim. Biophys. Acta | pmid:3036249 |
| Grignani G and Jamieson GA | Tissue factor-dependent activation of platelets by cells and microvesicles of SK-OS-10 human osteogenic sarcoma cell line. | 1987 | Invasion Metastasis | pmid:3036740 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Snyder F et al. | Measurement of key enzyme activities involved in the metabolism of platelet activating factor. | 1987 | Meth. Enzymol. | pmid:3037250 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
| Ingraham LM et al. | In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes. | 1987 | Br. J. Haematol. | pmid:3038160 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Criscuoli M and Subissi A | Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:2880624 |
| Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Handley DA et al. | Inhibition by SRI 63-072 and SRI 63-119 of PAF-acether and immune complex effects in the guinea pig. | 1987 | Eur. J. Pharmacol. | pmid:2959489 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Terasawa M et al. | Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. | 1987 | Jpn. J. Pharmacol. | pmid:3682404 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
| Egido J et al. | Role of platelet-activating factor in adriamycin-induced nephropathy in rats. | 1987 | Eur. J. Pharmacol. | pmid:3622604 |
| Kawaguchi H and Yasuda H | Effects of platelet-activating factor on conversion of angiotensin I to II. | 1987 | FEBS Lett. | pmid:3622769 |
| Ninio E et al. | Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. | 1987 | J. Immunol. | pmid:3584983 |
| Casals-Stenzel J | Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3587377 |
| Brambilla A et al. | WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. | 1987 | Pharmacol Res Commun | pmid:3588650 |
| Purdon AD et al. | Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3100454 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
| Casals-Stenzel J et al. | Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. | 1987 | Br. J. Pharmacol. | pmid:3664079 |
| Robertson DN and Page CP | Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. | 1987 | Br. J. Pharmacol. | pmid:3664082 |
| Whittle BJ et al. | Increased intestinal formation of Paf in endotoxin-induced damage in the rat. | 1987 | Br. J. Pharmacol. | pmid:3664090 |
| Shigenobu K et al. | Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | J. Pharmacobio-dyn. | pmid:3625454 |
| Jensen NJ et al. | FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. | 1987 | Lipids | pmid:3626775 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Haroldsen PE et al. | Metabolism of platelet-activating factor in isolated perfused rat lung. | 1987 | J. Clin. Invest. | pmid:3108322 |
| Tahara T et al. | PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines. | 1987 | Chem. Pharm. Bull. | pmid:3664818 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| Levin M et al. | Platelet immune complex interaction in the pathogenesis of Kawasaki disease. | 1987 | Prog. Clin. Biol. Res. | pmid:3423040 |
| Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
| Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
| Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
| Sciberras DG et al. | Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation. | 1987 | Br J Clin Pharmacol | pmid:2449904 |
| Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
| Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
| Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
| Bossant MJ et al. | Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. | 1987 | J. Chromatogr. | pmid:3443654 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
| Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Lagente V et al. | Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. | 1987 | Braz. J. Med. Biol. Res. | pmid:3452452 |
| Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
| Gentry PA et al. | Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. | 1987 | Can. J. Vet. Res. | pmid:3453270 |
| Sugatani J et al. | Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation. | 1987 | J. Biol. Chem. | pmid:2824509 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Evans TW et al. | Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. | 1987 | J. Appl. Physiol. | pmid:3115939 |
| Knudsen BS et al. | Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. | 1987 | J. Clin. Invest. | pmid:3116043 |
| Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
| Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
| Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
| Sisson JH et al. | Production of platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism. | 1987 | J. Immunol. | pmid:3035016 |
| Michel L et al. | Biologic properties of LTB4 and paf-acether in vivo in human skin. | 1987 | J. Invest. Dermatol. | pmid:3035030 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Satouchi K et al. | 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. | 1987 | Lipids | pmid:3110532 |
| Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |