Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Camussi G et al. | Immune-induced leucopenia. A role for the aggregation of polymorphonuclear neutrophils in systemic lupus erythematosus (SLE). | 1981 Jul-Sep | Minerva Nefrol | pmid:7329598 |
Camussi G et al. | In vitro spasmogenic effect of platelet-activating factor on rabbit lung tissue. | 1981 Jul-Sep | Panminerva Med | pmid:7335369 |
Brown JE and Thuy LP | The binding of bovine platelet aggregating factor to human platelets. | 1981 Apr 1-15 | Thromb. Res. | pmid:7292446 |
Shaw JO et al. | Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor). | 1981 | J. Immunol. | pmid:6267133 |
Slauson DO and Sanchez-Vizcaino JM | Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. | 1981 | Vet. Pathol. | pmid:6170156 |
O'Donnell MC and Fiedel BA | Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. | 1981 | Scand. J. Immunol. | pmid:6171870 |
Benveniste J | Platelet-activating factor (PAF-acether): present status. | 1981 | Agents Actions | pmid:6176101 |
Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
Lee TC et al. | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6797422 |
Stimler NP et al. | Anaphylactic actions of platelet-activating factor. | 1981 | Am. J. Pathol. | pmid:6975043 |