Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hepatitis C, Chronic D019698 12 associated lipids
Coronary Stenosis D023921 6 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Encephalitis D004660 15 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Contracture D003286 3 associated lipids
Stomatitis D013280 14 associated lipids
Weight Loss D015431 56 associated lipids
Endotoxemia D019446 27 associated lipids
Blister D001768 16 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Lupus Nephritis D008181 8 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Ileal Diseases D007077 3 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Venous Thrombosis D020246 11 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Thrombophilia D019851 6 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Pelvic Pain D017699 7 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Leukostasis D018921 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Viremia D014766 4 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Bronchiectasis D001987 7 associated lipids
Anthrax D000881 1 associated lipids
Heart Injuries D006335 6 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Murakami K et al. A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. 1996 Thromb. Haemost. pmid:8822594
Koyama M et al. Surface coverage of vascular grafts with cultured human endothelial cells from subcutaneous fat tissue obtained with a biopsy needle. 1996 Thromb. Haemost. pmid:8903004
Castro-Faria-Neto HC et al. Platelet mobilization induced by PAF and its role in the thrombocytosis triggered by adrenaline in rats. 1989 Thromb. Haemost. pmid:2617459
den Dekker E et al. Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. 2001 Thromb. Haemost. pmid:11686331
Pipili E Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. 1985 Thromb. Haemost. pmid:2418525
Shindo K et al. Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. 1997 Thorax pmid:9516893
Chung KF Platelet activating factor revisited. 1997 Thorax pmid:9516891
Shindo K et al. Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. 1996 Thorax pmid:8711647
McFadden RG et al. Effect of platelet activating factor (PAF) on the migration of human lymphocytes. 1995 Thorax pmid:7660340
Spring J et al. Failure of salmeterol to inhibit circulating white cell responses and bronchoconstriction induced by platelet activating factor. 1992 Thorax pmid:1361250
Chung KF et al. Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. 1989 Thorax pmid:2648645
Chung KF and Barnes PJ Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. 1989 Thorax pmid:2648646
Summers C et al. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. 2014 Thorax pmid:24706039
Spencer DA et al. Participation of the cysteinyl leukotrienes in the acute bronchoconstrictor response to inhaled platelet activating factor in man. 1991 Thorax pmid:1858084
Freitag A et al. Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. 1993 Thorax pmid:8346486
Hoenderdos K et al. Hypoxia upregulates neutrophil degranulation and potential for tissue injury. 2016 Thorax pmid:27581620
Alabaster VA and Moore BA New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future. 1993 Thorax pmid:8493636
Roudebush WE and Diehl JR Platelet-activating factor content in boar spermatozoa correlates with fertility. 2001 Theriogenology pmid:11396471
O' Meara CM et al. Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. 2008 Theriogenology pmid:18248736
Bathgate R et al. Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. 2007 Theriogenology pmid:17157372
Kumar S and Sharma A Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. 2005 Theriogenology pmid:15763101
Desquand S [Effects of PAF antagonists in experimental models. Therapeutical perspectives]. 1993 Nov-Dec Therapie pmid:8091344
Zardini DM and Tschirhart EJ [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. 1999 Jan-Feb Therapie pmid:10216433
Willerson JT Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products. 1995 Tex Heart Inst J pmid:7787465
TatarskiÄ­ AR et al. [Use of plateletpheresis in the treatment of bronchial asthma]. 1991 Ter. Arkh. pmid:2063345
TatarskiÄ­ AR and Emirova AS [The role of the thrombocytes in the pathogenesis of certain forms of bronchial asthma]. 1990 Ter. Arkh. pmid:2142338
Skvortsov AA et al. [New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy]. 1989 Ter. Arkh. pmid:2727928
Miwa M [Catabolism of PAF and its regulation]. 1991 Tanpakushitsu Kakusan Koso pmid:2024018
Oda M et al. [PAF and diseases]. 1991 Tanpakushitsu Kakusan Koso pmid:2024019
Fukuda T and Makino S [Allergy and PAF]. 1991 Tanpakushitsu Kakusan Koso pmid:2024020
Yanoshita R [Phospholipid alteration and activation of phospholipase A2 in ischemic heart]. 1991 Tanpakushitsu Kakusan Koso pmid:2024024
Karasawa K and Nojima S [Production and application of antibodies to PAF]. 1991 Tanpakushitsu Kakusan Koso pmid:2024029
Tsujimoto M and Hori T [Activation of phospholipase A2 by cytokines]. 1991 Tanpakushitsu Kakusan Koso pmid:2024038
Ishii S and Shimizu T [Platelet-activating factor (PAF) receptor-related pathophysiology]. 1999 Tanpakushitsu Kakusan Koso pmid:10396985
Okiji T and Murota S [Chemical mediators]. 1991 Tanpakushitsu Kakusan Koso pmid:1901997
Mizoguchi H [Erythropoietin and thrombopoietin]. 1991 Tanpakushitsu Kakusan Koso pmid:1651533
Shindou H and Shimizu T [New development of lysophospholipid acyltransferases]. 2009 Tanpakushitsu Kakusan Koso pmid:19205351
Karasawa K [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. 2001 Tanpakushitsu Kakusan Koso pmid:11193332
Masugi F et al. [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. 1982 Tanpakushitsu Kakusan Koso pmid:6758041
Terasawa M [Platelet-activating factor (PAF) antagonists]. 1991 Tanpakushitsu Kakusan Koso pmid:1850862
Eser A et al. Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients. 2016 Taiwan J Obstet Gynecol pmid:26927250
Bazan NG and Allan G Signal transduction and gene expression in the eye: a contemporary view of the pro-inflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. 1997 Surv Ophthalmol pmid:9154273
Yaffe MB et al. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. 1999 Surgery pmid:10455891
Werner J et al. Multidrug strategies are effective in the treatment of severe experimental pancreatitis. 2012 Surgery pmid:21982067
Kim FJ et al. Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation. 1994 Surgery pmid:8047994
Schurr MJ et al. Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. 1997 Surgery pmid:9142146
Porras-Reyes BH and Mustoe TA Platelet-activating factor: improvement in wound healing by a chemotactic factor. 1992 Surgery pmid:1557687
Cuschieri J et al. Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. 2002 Surgery pmid:12219006
Liu T et al. Improved preservation of the rat liver for orthotopic liver transplantation: use of University of Wisconsin-lactobionate solution and retrograde reflushing. 1990 Surgery pmid:2237771
Wang KS et al. Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. 1993 Surgery pmid:8417492