Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hepatitis C, Chronic D019698 12 associated lipids
Coronary Stenosis D023921 6 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Encephalitis D004660 15 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Contracture D003286 3 associated lipids
Stomatitis D013280 14 associated lipids
Weight Loss D015431 56 associated lipids
Endotoxemia D019446 27 associated lipids
Blister D001768 16 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Lupus Nephritis D008181 8 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Ileal Diseases D007077 3 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gliosis D005911 6 associated lipids
Neuralgia D009437 28 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Amnesia D000647 12 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Sneezing D012912 6 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Helicobacter Infections D016481 21 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Mucositis D052016 7 associated lipids
Ileitis D007079 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Strongylida Infections D017206 5 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Venous Thrombosis D020246 11 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Thrombophilia D019851 6 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Colitis, Ischemic D017091 3 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Pelvic Pain D017699 7 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Capillary Leak Syndrome D019559 2 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Migraine without Aura D020326 1 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Leukostasis D018921 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Viremia D014766 4 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Bronchiectasis D001987 7 associated lipids
Anthrax D000881 1 associated lipids
Heart Injuries D006335 6 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Abu-Zidan FM Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. 1998 Surgery pmid:9481416
Botha AJ et al. Postinjury neutrophil priming and activation: an early vulnerable window. 1995 Surgery pmid:7638753
Biffl WL et al. Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. 2003 Surgery pmid:12874587
Partrick DA et al. Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. 1997 Surgery pmid:9288123
Porras-Reyes BH and Mustoe TA Platelet-activating factor: improvement in wound healing by a chemotactic factor. 1992 Surgery pmid:1557687
Read RA et al. Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion. 1993 Surgery pmid:8342134
Liu T et al. Improved preservation of the rat liver for orthotopic liver transplantation: use of University of Wisconsin-lactobionate solution and retrograde reflushing. 1990 Surgery pmid:2237771
Fukuoka T et al. The platelet activating factor as a pivotal mediator of shock after liver ischemia. 1995 Surg. Today pmid:7633127
Ono S et al. Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. 1993 Surg. Today pmid:8467174
Denham W and Norman J The potential role of therapeutic cytokine manipulation in acute pancreatitis. 1999 Surg. Clin. North Am. pmid:10470326
Biffl WL et al. Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. 2001 Surg Infect (Larchmt) pmid:12593704
Anderson BO et al. The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure. 1991 Surg Gynecol Obstet pmid:1851337
Wei Y et al. Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. 1998 Structure pmid:9562561
Sirén AL et al. Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. 1993 Stroke pmid:8506560
Lindsberg PJ et al. Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. 1990 Stroke pmid:2219210
Sirén AL et al. Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. 1992 Stroke pmid:1440713
Joseph R et al. Effect of therapy on platelet activating factor-induced aggregation in acute stroke. 1989 Stroke pmid:2718200
Joseph R and Welch KM Granulocytes, platelet activating factor, and stroke. 1989 Stroke pmid:2756548
Uhl E et al. Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. 1999 Stroke pmid:10187894
Uhl E et al. Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. 1999 Stroke pmid:10187895
Bielenberg GW et al. Infarct reduction by the platelet activating factor antagonist apafant in rats. 1992 Stroke pmid:1731428
Joseph R et al. Effect of ticlopidine and aspirin on platelet ionized calcium in ischemic stroke. 1991 Stroke pmid:2024285
Kochanek PM et al. Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. 1990 Stroke pmid:2309270
Feuerstein G et al. Platelet-activating factor. A putative mediator in central nervous system injury? 1990 Stroke pmid:2237991
Yoshida H et al. Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? 1993 Stroke pmid:8418541
Nishida K and Markey SP Platelet-activating factor in brain regions after transient ischemia in gerbils. 1996 Stroke pmid:8610322
Leont'ev VK and Kankanian AP [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. 1996 Stomatologiia (Mosk) pmid:8658569
Liu J et al. New vernocuminosides from the stem barks of Vernonia cumingiana Benth. 2009 Steroids pmid:18840454
Donnard M et al. Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. 2002 Stem Cells pmid:12351810
Costa M et al. Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. 2013 Stem Cell Res pmid:23164599
Wintroub BU and Soter NA Biology of the mast cell and its role in cutaneous inflammation. 1981 Springer Semin. Immunopathol. pmid:7022722
Baltás E et al. Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784066
Glaser KB et al. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. 1995 Skin Pharmacol. pmid:8688196
Mathiak G et al. Platelet-activating factor (PAF) in experimental and clinical sepsis. 1997 Shock pmid:9185238
Chen LW et al. Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. 2000 Shock pmid:10718373
Kruse-Elliott KT et al. Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. 1996 Shock pmid:8721386
Wang HG et al. The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. 1998 Shock pmid:9466475
Bar-Or D et al. Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 2003 Shock pmid:12865660
Ruggiero V et al. Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. 1994 Shock pmid:7757521
Froon AM et al. Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. 1996 Shock pmid:9156785
Enzan K et al. Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. 1996 Shock pmid:8885083
Childs EW et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. 2002 Shock pmid:12412620
Gomes RN et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. 2006 Shock pmid:16783197
Chen LW et al. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. 2006 Shock pmid:16783201
Zallen G et al. Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. 1999 Shock pmid:10030791
Granger J and Remick D Acute pancreatitis: models, markers, and mediators. 2005 Shock pmid:16374372
Bulger EM et al. The macrophage response to endotoxin requires platelet activating factor. 2002 Shock pmid:11900334
Mitsuoka H et al. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. 2002 Shock pmid:11900339
Park EJ et al. Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. 2007 Shock pmid:17510604
Aiboshi J et al. Blood transfusion and the two-insult model of post-injury multiple organ failure. 2001 Shock pmid:11303730