| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thrombasthenia | D013915 | 4 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
| Optic Nerve Injuries | D020221 | 4 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Viremia | D014766 | 4 associated lipids |
| AIDS Dementia Complex | D015526 | 4 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Liver Failure | D017093 | 5 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Granulomatosis with Polyangiitis | D014890 | 5 associated lipids |
| Spasm | D013035 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tokumura A et al. | Exogenously added alkylmethylglycerophosphocholine and alkylmethylcarbamylglycerophosphocholine accumulate in plasma membranes more than in intracellular membranes of rabbit platelets. | 1997 | Chem. Phys. Lipids | pmid:9149390 |
| Albert DH et al. | Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist. | 1997 | Eur. J. Pharmacol. | pmid:9151941 |
| Sei Y et al. | Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS. | 1997 | Eur. J. Pharmacol. | pmid:9151942 |
| FitzGerald GA | Cigarettes and the wages of sn-2: oxidized species of PAF in smoking hamsters. | 1997 | J. Clin. Invest. | pmid:9153267 |
| Lehr HA et al. | Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. | 1997 | J. Clin. Invest. | pmid:9153277 |
| Bazan NG and Allan G | Signal transduction and gene expression in the eye: a contemporary view of the pro-inflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. | 1997 | Surv Ophthalmol | pmid:9154273 |
| Bussolati B et al. | Modulatory effect of interleukin-10 on the production of platelet-activating factor and superoxide anions by human leucocytes. | 1997 | Immunology | pmid:9155653 |
| Lash GE and Legge M | Induction of early pregnancy factor activity in vitro by platelet-activating factor in mice. | 1997 | J. Reprod. Fertil. | pmid:9155726 |
| Ammit AJ and O'Neill C | The role of albumin in the release of platelet-activating factor by mouse preimplantation embryos in vitro. | 1997 | J. Reprod. Fertil. | pmid:9155741 |
| Velasquez LA et al. | Expression of platelet-activating factor receptor in the hamster oviduct: localization to the endosalpinx. | 1997 | J. Reprod. Fertil. | pmid:9155745 |
| Petersen LJ et al. | Platelet-activating factor induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade. | 1997 | J. Allergy Clin. Immunol. | pmid:9155831 |
| Froon AM et al. | Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. | 1996 | Shock | pmid:9156785 |
| El-Shazly AE et al. | Immunoregulatory effect of substance P in human eosinophil migratory function. | 1996 | Immunol. Invest. | pmid:9157054 |
| Stengel D et al. | Expression of the PAF receptor in human monocyte-derived macrophages is downregulated by oxidized LDL: relevance to the inflammatory phase of atherogenesis. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157961 |
| Frostegård J et al. | Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157962 |
| Ammit AJ and O'Neill C | Optimization of a method for deactivation of platelet-activating factor:acetylhydrolase in serum for use in in-vitro fertilization culture media. | 1997 | Hum. Reprod. | pmid:9159443 |
| Walker BA et al. | Adenosine A3 receptor expression and function in eosinophils. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9160835 |
| Berends C et al. | Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram. | 1997 | Eur. Respir. J. | pmid:9163638 |
| Herrero-Beaumont G and Egido J | PAF, a potent proinflammatory mediator, looking for its role in the pathogenesis of joint damage. | 1997 | Ann. Rheum. Dis. | pmid:9165991 |
| Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
| Chen J and Giris N | Species differences in PAF receptor binding in the lungs between hamster and guinea pig. | 1997 | J Lipid Mediat Cell Signal | pmid:9172049 |
| Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. II. Hydrophobicity study using the molecular lipophilicity potential. | 1997 | J Lipid Mediat Cell Signal | pmid:9172050 |
| Shindo K et al. | Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175174 |
| Leoncini G et al. | Hyperactivity and increased hydrogen peroxide formation in platelets of NIDDM patients. | 1997 | Thromb. Res. | pmid:9175236 |
| Despotis GJ et al. | Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood. | 1997 | Thromb. Res. | pmid:9175242 |
| Koyama S et al. | Type II pneumocytes release chemoattractant activity for monocytes constitutively. | 1997 | Am. J. Physiol. | pmid:9176245 |
| Lin CN et al. | 2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor. | 1997 | J. Pharm. Pharmacol. | pmid:9178190 |
| Vasänge M et al. | A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils. | 1997 | J. Pharm. Pharmacol. | pmid:9178195 |
| Kelefiotis D and Vakirtzi-Lemonias C | Kinetics of PAF transfer, distribution and metabolism in human blood in vitro. | 1997 | Life Sci. | pmid:9180364 |
| Stotland MA and Kerrigan CL | The role of platelet-activating factor in musculocutaneous flap reperfusion injury. | 1997 | Plast. Reconstr. Surg. | pmid:9180723 |
| Salcedo R et al. | Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase. | 1997 | Exp. Cell Res. | pmid:9184073 |
| Ephgrave K et al. | The role of platelet-activating factor in conscious, normotensive endotoxemia. | 1997 | J. Surg. Res. | pmid:9184676 |
| Bazan HE and Tao Y | PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration. | 1997 | J Ocul Pharmacol Ther | pmid:9185044 |
| Mathiak G et al. | Platelet-activating factor (PAF) in experimental and clinical sepsis. | 1997 | Shock | pmid:9185238 |
| Okubo Y et al. | Inhibitory effects of theophylline and procaterol on eosinophil function. | 1997 | Intern. Med. | pmid:9187566 |
| Lacasse C et al. | Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis factor for enhanced production of granulocyte-macrophage colony stimulating factor. | 1997 | Inflammation | pmid:9187959 |
| van der Weiden RM and Wouters JM | Infertility may sometimes be associated with non-steroidal anti-inflammatory drug consumption. | 1997 | Br. J. Rheumatol. | pmid:9189067 |
| Chen J and Giri SN | Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190835 |
| Hinterleitner TA et al. | Platelet-activating factor contributes to immune cell and oxidant-mediated intestinal secretion. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190862 |
| Teixeira MM et al. | Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. | 1997 | Blood | pmid:9192781 |
| Sharma R et al. | Direct effects of platelet-activating factor on glomerular capillary permeability. | 1997 | Kidney Blood Press. Res. | pmid:9192907 |
| Rodriguez-Roisin R | Acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities. | 1997 | Eur. Respir. J. | pmid:9192945 |
| Rocha MF et al. | Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes. | 1997 | Infect. Immun. | pmid:9199444 |
| Lin J et al. | Dexamethasone inhibits mucous glycoprotein secretion via a phospholipase A2-dependent mechanism in cultured chinchilla middle ear epithelial cells. | 1997 | Acta Otolaryngol. | pmid:9199527 |
| Liu B et al. | Effects of MTX and BN52021 on PAF-induced chemotaxis of PMNs and intraepidermal accumulation of inflammatory cells in guinea pigs. | 1996 | Chin. Med. J. | pmid:9206081 |
| Zhang S et al. | [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. | 1996 | Zhonghua Fu Chan Ke Za Zhi | pmid:9206185 |
| Bellone G et al. | Bone marrow stroma-derived prolactin is involved in basal and platelet-activating factor-stimulated in vitro erythropoiesis. | 1997 | Blood | pmid:9207433 |
| Hoffman BF et al. | Electrophysiologic effects of interactions between activated canine neutrophils and cardiac myocytes. | 1997 | J. Cardiovasc. Electrophysiol. | pmid:9209969 |
| Balestrieri ML et al. | The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells. | 1997 | J. Biol. Chem. | pmid:9211886 |
| Svetlov SI et al. | Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. | 1997 | Biochim. Biophys. Acta | pmid:9219895 |
| Winkler JD et al. | Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes. | 1997 | Biochim. Biophys. Acta | pmid:9219900 |
| Schwartz JD et al. | Lexipafant inhibits platelet activating factor enhanced neutrophil functions. | 1997 | J. Surg. Res. | pmid:9224389 |
| Korotaeva AA et al. | Effect of lysophosphatidylcholine on the structure and function of low density lipoproteins. | 1997 | Membr Cell Biol | pmid:9225256 |
| Lopes AH et al. | Effect of platelet-activating factor on the process of cellular differentiation of Herpetomonas muscarum muscarum. | 1997 Jul-Aug | J. Eukaryot. Microbiol. | pmid:9225446 |
| Serra MF et al. | Anti-allergic properties of the natural PAF antagonist yangambin. | 1997 | Planta Med. | pmid:9225600 |
| Dupuis F et al. | Production and metabolism of platelet-activating factor by human bone marrow cells. | 1997 | Res. Immunol. | pmid:9226766 |
| Denault S et al. | Transcriptional activation of the interleukin-8 gene by platelet-activating factor in human peripheral blood monocytes. | 1997 | Immunology | pmid:9227331 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Ammit AJ and O'Neill C | Studies of the nature of the binding by albumin of platelet-activating factor released from cells. | 1997 | J. Biol. Chem. | pmid:9228051 |
| Rhee CK et al. | Effects of platelet activating factor on vascular permeability of the middle ear mucosa. | 1997 | Ann. Otol. Rhinol. Laryngol. | pmid:9228864 |
| Evans DJ et al. | Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230719 |
| DÃaz O et al. | Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230720 |
| Triggiani M et al. | Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230731 |
| Pearson JM et al. | Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration. | 1997 | Toxicology | pmid:9231696 |
| Wang X and Evans RD | Effect of endotoxin and platelet-activating factor on lipid oxidation in the rat heart. | 1997 | J. Mol. Cell. Cardiol. | pmid:9236145 |
| Filep JG et al. | Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. | 1997 | Circulation | pmid:9236448 |
| Roussev RG et al. | Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization. | 1996 | Mol. Hum. Reprod. | pmid:9237230 |
| Sengoku K et al. | Involvement of protein kinases in platelet activating factor-induced acrosome reaction of human spermatozoa. | 1996 | Mol. Hum. Reprod. | pmid:9238710 |
| Bunting M et al. | Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. | 1997 | J. Clin. Invest. | pmid:9239403 |
| Davies MG and Hagen PO | Systemic inflammatory response syndrome. | 1997 | Br J Surg | pmid:9240130 |
| Henninger DD et al. | Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. | 1997 | Circ. Res. | pmid:9242189 |
| Nakajima K et al. | Activated mast cells release extracellular type platelet-activating factor acetylhydrolase that contributes to autocrine inactivation of platelet-activating factor. | 1997 | J. Biol. Chem. | pmid:9242626 |
| Barnett CC et al. | Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release. | 1997 | J. Surg. Res. | pmid:9245567 |
| Dupuis F et al. | Effects of lipidic mediators on the growth of human myeloid and erythroid marrow progenitors. | 1997 | J Lipid Mediat Cell Signal | pmid:9246601 |
| Travers JB et al. | Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9246603 |
| Rougier F et al. | Platelet-activating factor and antagonists modulate DNA synthesis in human bone marrow stromal cell cultures. | 1997 | J Lipid Mediat Cell Signal | pmid:9246604 |
| Binisti C et al. | A new phospholipase A2 inhibitor, unrelated to substrate analogues: kinetic characterization of the inhibition of secretory phospholipases A2 by PMS 832. | 1997 | J Lipid Mediat Cell Signal | pmid:9246606 |
| Ereth MH et al. | Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass? | 1997 | Anesth. Analg. | pmid:9249097 |
| Xie J et al. | Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. | 1997 | Am. J. Physiol. | pmid:9249487 |
| MartÃnez-Salgado C et al. | Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. | 1997 | Am. J. Physiol. | pmid:9249592 |
| Montrucchio G et al. | Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. | 1997 | Am. J. Pathol. | pmid:9250168 |
| Korth RM | Specific binding sites for 1-O-alkyl-sn-glyceryl-3-phosphorylcholine on intact human blood neutrophils. | 1997 | Int. Arch. Allergy Immunol. | pmid:9250592 |
| Avramopoulou V et al. | Synthesis of a new phosphoglycolipid with biological activity towards platelets. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9251244 |
| Balsinde J et al. | Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. | 1997 | J. Biol. Chem. | pmid:9252342 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Shebzukhov IuV and Mysiakin EB | [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. | 1996 Oct-Dec | Vopr. Med. Khim. | pmid:9254510 |
| Teng CM et al. | Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. | 1997 | J. Pharm. Pharmacol. | pmid:9255715 |
| Takahashi S et al. | Role of platelet-activating factor in two-kidney, one-clip hypertension. | 1997 | Int. J. Urol. | pmid:9256329 |
| Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
| Grimminger F et al. | Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. | 1997 | J. Immunol. | pmid:9257856 |
| Alonso MT et al. | Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis. | 1997 | Br. J. Pharmacol. | pmid:9257915 |
| Palmer JS et al. | A platelet activating factor antagonist attenuates the effects of testicular ischemia. | 1997 | J. Urol. | pmid:9258168 |
| Ruiz-Ortega M et al. | Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta. | 1997 | J. Am. Soc. Nephrol. | pmid:9259353 |
| Le Gouill C et al. | Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor. | 1997 | J. Biol. Chem. | pmid:9261140 |
| Tung DK et al. | Leukocyte contribution to parenchymal cell death in an experimental model of inflammation. | 1997 | J. Leukoc. Biol. | pmid:9261330 |
| Waller KP | Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. | 1997 | Vet. Immunol. Immunopathol. | pmid:9261962 |
| Albert DH et al. | Ex vivo inhibition of beta-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist. | 1997 | Inflamm. Res. | pmid:9266276 |
| Shindo K et al. | PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266847 |