| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
| Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
| Munoz NM et al. | Effects of PAF on isolated rat airways perfused with blood-free solution. | 1991 | Am. J. Physiol. | pmid:2018147 |
| Olson NC et al. | Role of platelet-activating factor and eicosanoids during endotoxin-induced lung injury in pigs. | 1990 | Am. J. Physiol. | pmid:2163217 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Halonen M et al. | Anatomic basis for species differences in peripheral lung strip contraction to PAF. | 1990 | Am. J. Physiol. | pmid:2382734 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Gao Y et al. | PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. | 1995 | Am. J. Physiol. | pmid:7653635 |
| Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
| Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Snyder F | Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. | 1990 | Am. J. Physiol. | pmid:2240190 |
| Kubes P et al. | Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. | 1990 | Am. J. Physiol. | pmid:2240225 |
| Wallace JL | Lipid mediators of inflammation in gastric ulcer. | 1990 | Am. J. Physiol. | pmid:2405704 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Johnson A et al. | Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1991 | Am. J. Physiol. | pmid:1656789 |
| Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
| Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Wang GD et al. | Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17030900 |
| Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
| Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| Lautenschläger I et al. | A model of the isolated perfused rat small intestine. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19910525 |
| Lu J et al. | Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356536 |
| Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
| Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |