| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| DeFeudis FV | Studies on endothelium-dependent vasorelaxation. | 1986 | Gen. Pharmacol. | pmid:3512363 |
| Wardlow ML et al. | Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor. | 1986 | J. Immunol. | pmid:3514760 |
| Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
| Vanhoutte PM et al. | Modulation of vascular smooth muscle contraction by the endothelium. | 1986 | Annu. Rev. Physiol. | pmid:2871807 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Silva PM et al. | Platelet involvement in rat paw edema induced by 2-methoxy-PAF. | 1986 | Inflammation | pmid:3793206 |
| Wu MS et al. | Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3795043 |
| Desquand S et al. | Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | 1986 | Eur. J. Pharmacol. | pmid:3019727 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Muirhead EE et al. | Renal medullary system of blood pressure control. | 1986 | J Hypertens Suppl | pmid:3534182 |
| Foegh ML et al. | The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats. | 1986 | Pharmacol Res Commun | pmid:3534895 |
| Daniel LW et al. | A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. | 1986 | J. Biol. Chem. | pmid:3087989 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
| Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
| Fechter M et al. | Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants. | 1986 | Exp Pathol | pmid:3013671 |
| Coëffier E et al. | Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. | 1986 | Br. J. Haematol. | pmid:3964558 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| Bachelet M et al. | Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3092866 |
| Alonso F et al. | A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. | 1986 | Biochim. Biophys. Acta | pmid:3092867 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Dewald B and Baggiolini M | Platelet-activating factor as a stimulus of exocytosis in human neutrophils. | 1986 | Biochim. Biophys. Acta | pmid:3017443 |
| Mossmann H et al. | Effect of platelet-activating factor on human polymorphonuclear leukocyte enhancement of chemiluminescence and antibody-dependent cellular cytotoxicity. | 1986 | J. Leukoc. Biol. | pmid:3455715 |
| Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
| Kester M et al. | Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. | 1986 | Biochim. Biophys. Acta | pmid:3019423 |
| Voelkel NF et al. | PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. | 1986 | Prostaglandins | pmid:3024235 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Maes L et al. | Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. | 1986 | Pharmacol Res Commun | pmid:3774852 |
| Handley DA et al. | Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. | 1986 | Thromb. Haemost. | pmid:3775689 |
| Hwang SB and Lam MH | Species difference in the specific receptors of platelet activating factor. | 1986 | Biochem. Pharmacol. | pmid:3024653 |
| Han GQ et al. | [Neolignans from Piper hancei Maxim]. | 1986 | Yao Xue Xue Bao | pmid:3776545 |
| Montrucchio G et al. | Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. | 1986 | Int J Tissue React | pmid:3025124 |