Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Agwu DE et al. Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. 1989 Biochem. Biophys. Res. Commun. pmid:2466463
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Slattery CW and Beaumont DO Sheep platelets as a model for human platelets: evidence for specific PAF (platelet activating factor) receptors. 1989 Thromb. Res. pmid:2554526
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Travers JB et al. Identification of functional platelet-activating factor receptors in Raji lymphoblasts. 1989 J. Immunol. pmid:2555416
Hosford D et al. Platelet-activating factor and cytokine interactions in shock. 1989 Resuscitation pmid:2555874
Murphy S and Welk G Arachidonic acid evokes inositol phospholipid hydrolysis in astrocytes. 1989 FEBS Lett. pmid:2509246
Jancar S et al. Paf-induced release of spasmogens from guinea-pig lungs. 1989 Br. J. Pharmacol. pmid:2538179
Stengel PW and Silbaugh SA Reversal of A23187-induced airway constriction in the guinea pig. 1989 J. Pharmacol. Exp. Ther. pmid:2495351
Wey HE Phorbol diester enhances calcium ionophore A23187-induced [3H]acetate incorporation into platelet-activating factor in murine macrophages: predominant incorporation into 1-O-acyl-2-acetyl-sn-glycero-3-phosphocholine. 1989 J. Cell. Biochem. pmid:2496135
Stewart AG et al. Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells. 1989 Br. J. Pharmacol. pmid:2497920
Cucala M et al. Central regulation of gastric acid secretion by platelet-activating factor in anesthesized rats. 1989 Prostaglandins pmid:2499013
Lomazova KD et al. [The thrombocyte-activation factor and endotoxin-induced thrombocyte activation]. 1989 Biull Eksp Biol Med pmid:2500157
Dembinska-Kiec A et al. The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. 1989 Prostaglandins pmid:2717778
Warren JS et al. Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. 1989 J. Clin. Invest. pmid:2536403
Kurihara K et al. Inhibition of platelet-activating factor (PAF)-induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist, BN 52021. 1989 J. Allergy Clin. Immunol. pmid:2536413
Hwang SB et al. Characterization of platelet-activating factor (PAF) receptor by specific binding of [3H]L-659,989, a PAF receptor antagonist, to rabbit platelet membranes: possible multiple conformational states of a single type of PAF receptors. 1989 Mol. Pharmacol. pmid:2536468
Brunelleschi S et al. Interference of WEB 2086 and BN 52021 with Paf-induced effects on guinea-pig trachea. 1989 Br. J. Pharmacol. pmid:2758225
Bazill GW and Dexter TM An antagonist to platelet activating factor counteracts the tumoricidal action of alkyl lysophospholipids. 1989 Biochem. Pharmacol. pmid:2536543
Etienne A et al. Protective effect of the PAF-antagonist BN 52021 on several models of gastro-intestinal mucosal damage in rats. 1989 Int J Tissue React pmid:2693389
Barzaghi G and Mong S Platelet activating factor-amidophosphonate (PAF-AP), a partial agonist inhibited platelet activating factor-induced calcium mobilization in human monocytic leukemic U-937 cell. 1989 Life Sci. pmid:2536882
Schlondorff D Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. 1989 Adv. Exp. Med. Biol. pmid:2696352
Remuzzi G Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. 1989 Adv. Exp. Med. Biol. pmid:2696353
Henson PM PAF--a perspective. 1989 Am. J. Respir. Cell Mol. Biol. pmid:2696514
Pirotzky E et al. Involvement of platelet-activating factor in renal processes. 1989 Adv. Lipid Res. pmid:2698054
Snyder F et al. Platelet-activating factor and related ether lipid mediators. Biological activities, metabolism, and regulation. 1989 Ann. N. Y. Acad. Sci. pmid:2698076
Okubo K et al. The existence of a platelet-activating factor (Paf-acether)-like substance in blister fluid derived from patients with bullous pemphigoid as demonstrated by human platelet aggregation techniques. 1989 Kurume Med J pmid:2700767
Naccache PH et al. Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action. 1989 Br. J. Pharmacol. pmid:2547474
Dulioust A et al. Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages. 1989 Biochem. J. pmid:2513801
Burch RM and Tiffany CW Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists. 1989 J. Cell. Physiol. pmid:2550484
Pritze S et al. Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro. 1989 Prog. Clin. Biol. Res. pmid:2798458
Dembinska-Kiec A et al. Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. 1989 Prog. Clin. Biol. Res. pmid:2798459
dos Santos OF et al. Effect of platelet-activating factor antagonist on cyclosporine nephrotoxicity. Glomerular hemodynamics evaluation. 1989 Transplantation pmid:2705209
Neuwirth R et al. Extra- and intracellular metabolism of platelet-activating factor by cultured mesangial cells. 1989 Am. J. Physiol. pmid:2705543
Christman BW and Blair IA Analysis of platelet activating factor in human saliva by gas chromatography/mass spectrometry. 1989 Biomed. Environ. Mass Spectrom. pmid:2706378
Varol FG et al. Platelet-activating factor stimulates phosphatidylinositol hydrolysis in the rat myometrium. 1989 Eur. J. Pharmacol. pmid:2707303
Burstein SH et al. Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid. 1989 J. Pharmacol. Exp. Ther. pmid:2553925
Danyoshi C et al. Pyrrolidine derivatives as inhibitors of platelet aggregation induced by platelet activating factor. 1989 Chem. Pharm. Bull. pmid:2805179
Macpherson JL et al. Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis. 1989 Clin. Exp. Immunol. pmid:2805409
Avdonin PV et al. Selective inactivation by endogenous protein kinase C of human platelet high-affinity GTPase coupled with PAF receptors. 1989 J. Mol. Cell. Cardiol. pmid:2543823
Ryan US Endothelium as a transducing surface. 1989 J. Mol. Cell. Cardiol. pmid:2543830
Straube W [Early embryonal signals]. 1989 Zentralbl Gynakol pmid:2665388
Carveth HJ et al. Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. 1989 Biochem. Biophys. Res. Commun. pmid:2665743
Sánchez Crespo M Biosynthesis of platelet-activating factor: the role of the remodeling pathway. 1989 Methods Find Exp Clin Pharmacol pmid:2666805
Kaminker AJ and Carreras LO [Physiopathology of thrombotic microangiopathy]. 1989 Sangre (Barc) pmid:2667170
Neuwirth R et al. Angiotensin II causes formation of platelet activating factor in cultured rat mesangial cells. 1989 Circ. Res. pmid:2720922
Koenderman L et al. Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route. 1989 J. Immunol. pmid:2911014
Abisogun AO et al. The involvement of platelet activating factor in ovulation. 1989 Science pmid:2911750
Benedetto C et al. Reduced serum inhibition of platelet-activating factor activity in preeclampsia. 1989 Am. J. Obstet. Gynecol. pmid:2912073
Bazill GW and Dexter TM Platelet activating factor antagonist L-652,731 inhibits thymidine transport. 1989 Biochem. Pharmacol. pmid:2914023
Petty AC and Scrutton MC Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists? 1989 Thromb. Res. pmid:2749609
VornovitskiÄ­ EG et al. [Cardiodepressive effect of platelet activating factor]. 1989 Biull Eksp Biol Med pmid:2914168
Gallin EK Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. 1989 Am. J. Physiol. pmid:2750892
Palmantier R et al. Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. 1989 Biochem. Biophys. Res. Commun. pmid:2751666
Ontell SJ et al. Pharmacologic modulation of experimental postischemic hepatic function. 1989 Ann. Surg. pmid:2916864
Gelas P et al. Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil. 1989 FEBS Lett. pmid:2753160
Filep J et al. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. 1989 Biochem. Biophys. Res. Commun. pmid:2916986
Tilley JW et al. Biphenylcarboxamide derivatives as antagonists of platelet-activating factor. 1989 J. Med. Chem. pmid:2754708
Braquet P et al. Role of cytokines and platelet-activating factor in microvascular immune injury. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2651321
Lee TH Pharmacological modulation of leukotriene and platelet activating factor biosynthesis and activities by alternative dietary fatty acids. 1989 Clin. Exp. Allergy pmid:2653575
Straube W [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. 1989 Zentralbl Gynakol pmid:2655355
Takayasu M et al. Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. 1989 Biochem. Biophys. Res. Commun. pmid:2655596
Pretolani M et al. From anti-asthma drugs to PAF-acether antagonism and back. Present status. 1989 Biochem. Pharmacol. pmid:2655601
Ney P and Schrör K E-type prostaglandins but not iloprost inhibit platelet activating factor-induced generation of leukotriene B4 by human polymorphonuclear leukocytes. 1989 Br. J. Pharmacol. pmid:2466513
Bruijnzeel PL et al. Inhibitory effects of nedocromil sodium on the in vitro induced migration and leukotriene formation of human granulocytes. 1989 Drugs pmid:2547570
Spina D et al. The role of platelet activating factor in allergic inflammation. 1989 Pulm Pharmacol pmid:2520484
Viossat I et al. Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2622972
De Vos C et al. Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine. 1989 Int. Arch. Allergy Appl. Immunol. pmid:2523357
Rylander R Role of endotoxin and glucan for the development of granulomatous disease in the lung. 1989 Sarcoidosis pmid:2623374
Hemmendinger S et al. Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. 1989 J. Allergy Clin. Immunol. pmid:2523922
Teles de Araújo A et al. Surfactant modifications and lipidic mediators in occupational lung diseases. 1989 Sarcoidosis pmid:2623375
Tomioka K et al. YM461, a PAF antagonist, blocks antigen-induced late airway responses and airway hyperresponsiveness in allergic sheep. 1989 Eur. J. Pharmacol. pmid:2620695
Benfenati E et al. Development of a mass spectrometric method to quantitate platelet activating factor in mouse urine. 1989 J. Lipid Res. pmid:2621424
Kaufman SE et al. Effects of human GM-CSF on neutrophil degranulation in vitro. 1989 Exp. Hematol. pmid:2502423
Sueoka K et al. In-vivo and in-vitro determination of components of rabbit early pregnancy factors. 1989 J. Reprod. Fertil. pmid:2621714
Prakash C et al. Synthesis of trideuterated O-alkyl platelet activating factor and lyso derivatives. 1989 Lipids pmid:2586235
Tou JS Platelet-activating factor regulates phospholipid metabolism in human neutrophils. 1989 Lipids pmid:2586238
Bradley LM et al. Influence of thromboxane A2 receptor antagonism on pulmonary vasoconstrictor responses. 1989 Pediatr. Res. pmid:2587116
Smith D et al. The effect of prophylactic anti-asthma drugs on PAF-induced platelet accumulation in the thorax of the guinea pig. 1989 Jpn. J. Pharmacol. pmid:2593374
Sanjar S et al. Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs. 1989 Jpn. J. Pharmacol. pmid:2593375
Omann GM et al. Oscillating actin polymerization/depolymerization responses in human polymorphonuclear leukocytes. 1989 J. Biol. Chem. pmid:2550438
Mózes T et al. Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. 1989 Am. J. Physiol. pmid:2802004
Saxena SP et al. Histamine formed in stimulated human platelets is cytoplasmic. 1989 Biochem. Biophys. Res. Commun. pmid:2803292
Schlondorff D et al. Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. 1989 Am. J. Physiol. pmid:2492160
Ormerod AD et al. Effects of alprazolam on platelet activating factor-induced wealing. 1989 Br. J. Dermatol. pmid:2803963
Shattil SJ et al. Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists. 1989 Blood pmid:2535942
Heidel JR et al. Characterization of arachidonic acid metabolism, superoxide production, and bacterial killing in bovine circulating neutrophils and elicited alveolar neutrophils. 1989 J. Leukoc. Biol. pmid:2543724
Randriamampita C and Trautmann A Biphasic increase in intracellular calcium induced by platelet-activating factor in macrophages. 1989 FEBS Lett. pmid:2544447
Uhl D [Platelet activating factor and platelet activating factor antagonists. New methods in asthma therapy?]. 1989 Med Monatsschr Pharm pmid:2544789