| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mencia-Huerta JM et al. | Acute and long-term pulmonary effects of platelet-activating factor. | 1989 | Clin. Exp. Allergy | pmid:2473829 |
| Pretolani M et al. | Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs. | 1989 | Br. J. Pharmacol. | pmid:2474345 |
| Touqui L et al. | Gamma-thrombin-induced phospholipase A2 activation in rabbit platelets: comparison with alpha-thrombin. | 1989 | FEBS Lett. | pmid:2507360 |
| O'Neill C et al. | Supplementation of in-vitro fertilisation culture medium with platelet activating factor. | 1989 | Lancet | pmid:2476641 |
| Medeiros YS and Calixto JB | Effect of PAF-acether on the reactivity of the isolated rat myometrium. | 1989 | Braz. J. Med. Biol. Res. | pmid:2636008 |
| Martins MA et al. | Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats. | 1989 | Braz. J. Med. Biol. Res. | pmid:2636011 |
| Violi F et al. | Inhibition of cyclooxygenase-independent platelet aggregation by sodium salicylate. | 1989 | Thromb. Res. | pmid:2506658 |
| Piper PJ and Yaacob HB | Interactions of platelet activating factor, thromboxane A2 and leukotrienes in guinea-pig heart. | 1989 | Prog. Clin. Biol. Res. | pmid:2508116 |
| Denizot Y and Benveniste J | [Contamination of fermented milk products by proinflammatory autacoid paf-acether]. | 1989 | C. R. Acad. Sci. III, Sci. Vie | pmid:2510911 |
| Dent G et al. | Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. Correlation between receptor binding and function. | 1989 | FEBS Lett. | pmid:2537761 |
| Pitton C et al. | Presence of PAF-acether in human breast carcinoma: relation to axillary lymph node metastasis. | 1989 | J. Natl. Cancer Inst. | pmid:2769781 |
| Tolins JP et al. | Role of platelet activating factor in endotoxemic acute renal failure in the male rat. | 1989 | J. Lab. Clin. Med. | pmid:2538527 |
| Kioka K et al. | [Changes in production of platelet activating factor by adherent hepatocytes of mice with experimental liver failure]. | 1989 | Nihon Shokakibyo Gakkai Zasshi | pmid:2770018 |
| Panetta T et al. | Arachidonic acid metabolism and cerebral blood flow in the normal, ischemic, and reperfused gerbil brain. Inhibition of ischemia-reperfusion-induced cerebral injury by a platelet-activating factor antagonist (BN 52021). | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774404 |
| Filep J and Földes-Filep E | Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor. | 1989 | Life Sci. | pmid:2538700 |
| Chao W et al. | Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells. | 1989 | Biochem. J. | pmid:2775221 |
| Shukla SD et al. | Desensitization of platelet-activating factor-stimulated protein phosphorylation in platelets. | 1989 | Mol. Pharmacol. | pmid:2539556 |
| Sawyer DB and Andersen OS | Platelet-activating factor is a general membrane perturbant. | 1989 | Biochim. Biophys. Acta | pmid:2480815 |
| Filipponi F et al. | Prolongation of guinea pig-to-rat xenograft survival with BN 52063, a specific antagonist of platelet-activating factor. | 1989 | Ital J Surg Sci | pmid:2483404 |
| Murphy TM et al. | PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo. | 1989 | J. Appl. Physiol. | pmid:2708195 |
| RodrÃguez-Puyol D et al. | Actions of cyclosporin A on cultured rat mesangial cells. | 1989 | Kidney Int. | pmid:2709669 |
| Sanchez Crespo M and Nieto ML | Modulation of PAF biosynthesis in human polymorphonuclear leukocytes. The role of phorbol esters and protein kinases. | 1989 | Agents Actions | pmid:2711927 |
| Weichert W and Breddin HK | A PAF-acether antagonist (N 48740 RP/Rhône-Poulenc) and laser-induced thrombi in rat mesenteric vessels. | 1989 | Haemostasis | pmid:2807041 |
| Guarner F et al. | Endotoxin-induced ascites formation in the rat: partial mediation by platelet-activating factor. | 1989 | Hepatology | pmid:2807157 |
| Yukawa T et al. | Density heterogeneity of eosinophil leucocytes: induction of hypodense eosinophils by platelet-activating factor. | 1989 | Immunology | pmid:2807369 |
| Suematsu M et al. | In vivo visualization of oxyradical-dependent photoemission during endothelium-granulocyte interaction in microvascular beds treated with platelet-activating factor. | 1989 | J. Biochem. | pmid:2808326 |
| Oh-ishi S et al. | Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate. | 1989 | Dermatologica | pmid:2673856 |
| McNamara PJ et al. | The interaction of alpha-1-acid glycoprotein with endogenous autocoids, in particular, platelet activating factor (PAF). | 1989 | Prog. Clin. Biol. Res. | pmid:2674967 |
| Braquet P and Hosford D | The potential role of platelet-activating factor (PAF) in shock, sepsis and adult respiratory distress syndrome (ARDS). | 1989 | Prog. Clin. Biol. Res. | pmid:2675060 |
| Morita E et al. | Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. | 1989 | Scand. J. Immunol. | pmid:2544988 |
| Joseph R and Welch KM | Granulocytes, platelet activating factor, and stroke. | 1989 | Stroke | pmid:2756548 |
| Medeiros YS et al. | Tracheal responsiveness to histamine, PAF-acether and acetylcholine in normal and actively ovalbumin-sensitized guinea pigs. | 1989 | Braz. J. Med. Biol. Res. | pmid:2758178 |
| Esplugues JV et al. | Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf. | 1989 | Br. J. Pharmacol. | pmid:2758231 |
| Denizot Y et al. | Paf-acether production by Escherichia coli. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2660796 |
| Peterson JR et al. | Platelet activating factor antagonist design. 3. X-ray crystal structure and intermolecular crystal lattice interactions of methyl trans-4-acetoxymethyl-4,5-dihydro-2,5-bis(3,4-methylenedioxyphenyl)- 3-furancarboxylate. | 1989 | Acta Crystallogr C | pmid:2604943 |
| Miyazaki H et al. | Lactone and cyclic ether analogues of platelet-activating factor. Synthesis and biological activities. | 1989 | Chem. Pharm. Bull. | pmid:2605681 |
| Ney P and Schrör K | E-type prostaglandins but not iloprost inhibit platelet activating factor-induced generation of leukotriene B4 by human polymorphonuclear leukocytes. | 1989 | Br. J. Pharmacol. | pmid:2466513 |
| Fisher GJ et al. | Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2476985 |
| Maridonneau-Parini I et al. | Inhibition of O2- generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages. | 1989 | J. Clin. Invest. | pmid:2542378 |
| Zavoico GB et al. | IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis. | 1989 | J. Immunol. | pmid:2497185 |
| Skvortsov AA et al. | [New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy]. | 1989 | Ter. Arkh. | pmid:2727928 |
| Desquand S et al. | Antigen-induced bronchopulmonary alterations in the guinea pig: a new model of passive sensitization mediated by mouse IgE antibodies. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2731996 |
| Verbey NL et al. | Platelet-activating factor and laser trauma of the iris. | 1989 | Invest. Ophthalmol. Vis. Sci. | pmid:2732024 |
| Munoz NM et al. | Evidence for platelet-activating factor secretion during immune activation in dogs. | 1989 | J. Appl. Physiol. | pmid:2732178 |
| Koenderman L et al. | 1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation. | 1989 | FEBS Lett. | pmid:2597277 |
| Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
| Ng DS and Wong K | Platelet-activating factor (PAF) stimulates phosphatidylinositol hydrolysis in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2557657 |
| Baker RC et al. | Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid. | 1989 | Alcohol. Clin. Exp. Res. | pmid:2557776 |
| O'Flaherty JT and Jacobson D | Protein kinase C blockers and neutrophil receptors for leukotriene B4. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551291 |
| Shen TY et al. | Recent development of platelet-activating factor antagonists. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546389 |
| Handley DA et al. | Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546390 |
| Remy E et al. | Inhibition of platelet-activating factor biosynthesis via the acetyltransferase by arachidonic and oleic acids in ionophore A23187-stimulated bovine neutrophils. | 1989 | Biochim. Biophys. Acta | pmid:2505852 |
| Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
| Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
| Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
| Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
| Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
| Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
| Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
| Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
| Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
| Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
| Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
| Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| Sun XM and Hsueh W | Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. | 1988 | J. Clin. Invest. | pmid:3366898 |
| Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
| Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
| Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
| Cueva JP and Hsueh W | Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. | 1988 | Gut | pmid:3197995 |
| Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
| Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
| Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
| Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
| Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
| Arnout J et al. | Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man. | 1988 | Br J Clin Pharmacol | pmid:3289599 |
| O'Donnell SR and Barnett CJ | pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. | 1988 | Br. J. Pharmacol. | pmid:3293683 |
| Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
| Kramer RM et al. | Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | 1988 | Biochim. Biophys. Acta | pmid:3355850 |
| Blank ML et al. | Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. | 1988 | J. Biol. Chem. | pmid:2833508 |
| Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
| Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
| Ontell SJ et al. | Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441. | 1988 | Gastroenterology | pmid:3263295 |
| Breviario F et al. | IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. | 1988 | J. Immunol. | pmid:3263425 |
| Croft KD et al. | The effect of dietary fish oil and long-term salt loading on blood pressure and eicosanoid metabolism in spontaneously hypertensive rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3271614 |
| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
| Mickelson JK et al. | Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. | 1988 | J. Mol. Cell. Cardiol. | pmid:3216407 |
| Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
| Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |