| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Podsiadly BT et al. | Prefertilization treatment of mice with platelet activating factor affects pregnancy. | 1992 | Mol. Reprod. Dev. | pmid:1497884 |
| Adamson LM et al. | Studies on murine embryo-derived platelet-activating factor (EPAF). | 1991 | Mol. Reprod. Dev. | pmid:1793598 |
| Xu Z et al. | Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor. | 2010 | Mol. Ther. | pmid:19953082 |
| Judge A et al. | Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. | 2006 | Mol. Ther. | pmid:16275098 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Jalil J et al. | Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King. | 2012 | Molecules | pmid:22964504 |
| Chia YC et al. | Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. | 2008 | Molecules | pmid:18259135 |
| Saadawi S et al. | Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin Eâ‚‚ and Thromboxane Bâ‚‚ production and platelet activating factor receptor binding. | 2012 | Molecules | pmid:22538486 |
| Bellofiore S et al. | Inhaled platelet-activating factor increases airway sensitivity but not maximal airway narrowing to methacholine in normal subjects. | 1994 | Monaldi Arch Chest Dis | pmid:8000412 |
| Dugas B et al. | Pharmacological modulation of the expression of the low affinity IgE receptor. | 1991 | Monogr Allergy | pmid:1836540 |
| Pinckard RN | The "new" chemical mediators of inflammation. | 1982 | Monogr Pathol | pmid:6126808 |
| Kuenemann-Migeot C et al. | Urinary promutagens of smokers: comparison of concentration methods and relation to cigarette consumption. | 1996 | Mutat. Res. | pmid:8684404 |
| Kalkanci A et al. | The role of tumour necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) interaction on murine candidosis. | 2002 | Mycoses | pmid:12000505 |
| Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
| Vadas P et al. | Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172172 |
| Burks AW | Factoring PAF in anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18172180 |
| Cerletti C et al. | Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. | 1986 | N. Engl. J. Med. | pmid:3941724 |
| Renal syndromes and nonsteroidal antiinflammatory drugs. | 1984 | N. Engl. J. Med. | pmid:6738607 | |
| Bansal AS et al. | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389523 |
| Okamoto H and Kamatani N | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18389524 |
| Levy JH | Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. | 2008 | N. Engl. J. Med. | pmid:18385504 |
| Serafin WE and Austen KF | Mediators of immediate hypersensitivity reactions. | 1987 | N. Engl. J. Med. | pmid:2438554 |
| Grandel KE et al. | Association of platelet-activating factor with primary acquired cold urticaria. | 1985 | N. Engl. J. Med. | pmid:2410790 |
| Newhouse MT and Sears MR | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3462569 |
| Morley J and Sanjar S | Ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466080 |
| Page CP | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466093 |
| Morley J and Sanjar S | PAF, ketotifen and asthma. | 1987 | N. Z. Med. J. | pmid:3468405 |
| Du Y et al. | Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. | 2012 | Nat Commun | pmid:22910354 |
| Coy Barrera ED and Cuca Suárez LE | In vitro inhibitory activities of Lauraceae aporphine alkaloids. | 2010 | Nat Prod Commun | pmid:20420312 |
| Marshall JC | Such stuff as dreams are made on: mediator-directed therapy in sepsis. | 2003 | Nat Rev Drug Discov | pmid:12750742 |
| Göggel R et al. | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. | 2004 | Nat. Med. | pmid:14704790 |
| Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
| Jasamai M et al. | Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. | 2015 | Nat. Prod. Res. | pmid:25332053 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Abu-Zidan FM | Hope or hype for lexipafant? | 1998 | Nature | pmid:9774090 |
| Bazan NG | Inflammation. A signal terminator. | 1995 | Nature | pmid:7700374 |
| Tjoelker LW et al. | Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. | 1995 | Nature | pmid:7700381 |
| Cundell DR et al. | Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. | 1995 | Nature | pmid:7566121 |
| Chen XS et al. | Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. | 1994 | Nature | pmid:7969451 |
| Hattori M et al. | Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. | 1994 | Nature | pmid:8028668 |
| Cusack NJ | Platelet-activating factor. | 1980 | Nature | pmid:7374771 |
| Kato K et al. | Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation. | 1994 | Nature | pmid:8114914 |
| Ho YS et al. | Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. | 1997 | Nature | pmid:8985254 |
| Rothhut B | Benveniste's reputation was not written in water. | 2004 | Nature | pmid:15565124 |
| Barnes PJ | Molecular biology. Inflammatory activities. | 1991 | Nature | pmid:1846227 |
| Honda Z et al. | Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. | 1991 | Nature | pmid:1846231 |
| Chap H et al. | Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. | 1981 | Nature | pmid:7453828 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Uozumi N et al. | Role of cytosolic phospholipase A2 in allergic response and parturition. | 1997 | Nature | pmid:9403692 |
| Seifert R et al. | Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. | 1989 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2552328 |
| Casals-Stenzel J | Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3587377 |
| Berger F et al. | Activation of a potassium outward current by zymosan and opsonized zymosan in mouse peritoneal macrophages. | 1994 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7969511 |
| Del Monte M and Subissi A | Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3149718 |
| Etienne A et al. | Role of neutrophils in gastric damage induced by platelet activating factor. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3244384 |
| Uhlig S et al. | Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation in isolated rat lung. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8938670 |
| Mascolo N et al. | Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8738301 |
| Ortiz JL et al. | Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induced airway hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8717161 |
| Mathison R and Davison JS | Capsaicin sensitive nerves in the jejunum of Nippostrongylus brasiliensis-sensitized rats participate in a cardiovascular depressor reflex. | 1993 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:7510855 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Saitoh C et al. | Effect of YM934, a KATP channel opener, on airway hyperresponsiveness induced by platelet activating factor in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050013 |
| Lin CH et al. | The effect of the selective PAF antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050014 |
| Pantaler E and Lückhoff A | Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894037 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Heuer HO et al. | Action of the racemate and the isomers of the platelet-activating factor antagonist bepafant (WEB 2170) after oral administration to guinea-pigs and rats. | 1991 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:1881464 |
| Stahl GL et al. | PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3431598 |
| Chiba Y et al. | Endothelium-dependent relaxant action of platelet activating factor in the rat mesenteric artery. | 1990 Jan-Feb | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2314485 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Uluoglu C and Timlioglu O | Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia and reperfusion: effects of antagonizing platelet activating factor (PAF). | 1999 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10543435 |
| ten Cate H et al. | [Current viewpoints and hypotheses concerning in vivo blood coagulation]. | 1993 | Ned Tijdschr Geneeskd | pmid:8433772 |
| Koltai M et al. | PAF-cytokine autocatalytic feed-back network in septic shock: involvement in acute renal failure. | 1994 | Nephrol. Dial. Transplant. | pmid:7800272 |
| Tetta C et al. | Adherence of human monocytes to haemodialysis membranes: LFA 1 (CD11a/CD18) CR1 (CD35) and CR3 (CD11b/CD18) triggering promotes the biosynthesis of platelet-activating factor and adherence. | 1995 | Nephrol. Dial. Transplant. | pmid:8559489 |
| Mariano F et al. | Production of platelet-activating factor in patients with sepsis-associated acute renal failure. | 1999 | Nephrol. Dial. Transplant. | pmid:10344354 |
| David S et al. | Adherence of human monocytes to haemodialysis membranes. | 1993 | Nephrol. Dial. Transplant. | pmid:8302460 |
| Jocks T et al. | Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury. | 1998 | Nephrol. Dial. Transplant. | pmid:9481713 |
| Götze O | The potential role of basophilic leukocytes and mast cells. | 1994 | Nephrol. Dial. Transplant. | pmid:7520557 |
| Bustos C et al. | Urinary excretion of platelet-activating factor in human and experimental nephrosis. | 1996 | Nephrol. Dial. Transplant. | pmid:8671780 |
| Bagnis C et al. | Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist. | 1996 | Nephrol. Dial. Transplant. | pmid:8671822 |
| Gastaldello K et al. | Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. | 2000 | Nephrol. Dial. Transplant. | pmid:11007834 |
| Ruiz-Ortega M et al. | Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating-factor stimulation. | 1998 | Nephrol. Dial. Transplant. | pmid:9568845 |
| Denizot Y et al. | Deregulated platelet-activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy. | 2000 | Nephrol. Dial. Transplant. | pmid:10978389 |
| de Arriba G et al. | Changes in glomerular cross-sectional area induced by platelet activating factor. | 1987 | Nephrol. Dial. Transplant. | pmid:3118261 |
| Cavallo-Perin P et al. | Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria. | 2000 | Nephrol. Dial. Transplant. | pmid:10862637 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Iatrou C et al. | Is platelet-activating factor produced during hemodialysis with AN-69 polyacrylonitrile membrane? | 2002 | Nephron | pmid:12021524 |
| Hemmendinger S et al. | Mitogenic activity on human arterial smooth muscle cells is increased in the plasma of patients undergoing hemodialysis with cuprophane membranes. | 1989 | Nephron | pmid:2812169 |
| Iida H et al. | Effects of the platelet-activating factor antagonists CV-6209 and CV-3988 on nephrotoxic serum nephritis in the rat. | 1992 | Nephron | pmid:1584324 |
| Iatrou C et al. | Platelet-activating factor levels and PAF acetylhydrolase activities in patients with primary glomerulonephritis. | 1996 | Nephron | pmid:8730430 |
| Sakaguchi K et al. | Increases in circulating level of platelet-activating factor lag behind transient neutropenia during hemodialysis with cuprophane membranes. | 1991 | Nephron | pmid:1758537 |
| Mazer BD et al. | B-cell activation and regulation of immunoglobulin synthesis by platelet activating factor. | 1991 | Neth J Med | pmid:1791887 |
| Teather LA et al. | Effects of posttraining intrahippocampal injections of platelet-activating factor and PAF antagonists on memory. | 1998 | Neurobiol Learn Mem | pmid:9774526 |
| Packard MG et al. | Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory. | 1996 | Neurobiol Learn Mem | pmid:8946410 |
| Teather LA et al. | Differential interaction of platelet-activating factor and NMDA receptor function in hippocampal and dorsal striatal memory processes. | 2001 | Neurobiol Learn Mem | pmid:11300737 |
| Hershkowitz M and Adunsky A | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. | 1996 Nov-Dec | Neurobiol. Aging | pmid:9363797 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Bussolino F et al. | Multiple roles of platelet-activating factor in the nervous system. | 1995 | Neurochem. Int. | pmid:7492940 |
| Shi C et al. | H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. | 2010 | Neurochem. Int. | pmid:20362023 |
| Dell' Albani P et al. | Platelet-activating factor and its methoxy-analogue ET-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures. | 1993 | Neurochem. Int. | pmid:8513284 |
| Ha SW and Lee CS | Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation. | 2010 May-Jun | Neurochem. Int. | pmid:20304020 |
| Bazan NG et al. | Bioactive lipids in excitatory neurotransmission and neuronal plasticity. | 1997 | Neurochem. Int. | pmid:9017670 |