Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Sagara K et al. Gastrointestinal physiology-regulated dogs: utilization of a bioavailability study of a new thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]-diazepine, an antagonist of platelet-activating factor, and its preparations. 1994 Biol. Pharm. Bull. pmid:8148798
Bouvier C et al. Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity. 1994 Circ. Shock pmid:8149505
Beilin LJ et al. Neutrophil platelet-activating factor in normal and hypertensive pregnancy and in pregnancy-induced hypertension. 1993 Clin. Sci. pmid:8149697
Li HP and Zhang RX Measurement of platelet-activating factor in human blood by high performance thin layer chromatography and its clinical application. 1993 J. Tongji Med. Univ. pmid:8151742
Liu T et al. Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia. 1993 Neurosci. Lett. pmid:8152586
Hayashi N et al. Effect of platelet-activating factor and platelet factor 4 on eosinophil adhesion. 1994 Int. Arch. Allergy Immunol. pmid:8156006
Bazan HE et al. Differences in the acyl composition of the platelet-activating factor (PAF) precursor and other choline phosphoglycerides of the rabbit retinal rod outer segments and neural retina. 1994 Curr. Eye Res. pmid:8156825
Green PG et al. Effect of E-type prostaglandins on bradykinin-induced plasma extravasation in the knee joint of the rat. 1994 Eur. J. Pharmacol. pmid:8157052
Sun D and Gilboe DD Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia. 1994 J. Neurochem. pmid:8158141
Guo ZM et al. Changes in platelet-activating factor, catecholamine, and serotonin concentrations in brain, cerebrospinal fluid, and plasma of pichinde virus-infected guinea pigs. 1993 Lab. Anim. Sci. pmid:8158981
Kobayashi I et al. Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. 1994 Am. J. Physiol. pmid:8160825
Zimmerman BJ et al. Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. 1994 Am. J. Physiol. pmid:8160832
Rothenberger DA and Wiltz O [Etiology of "pouchitis"]. 1993 Ann Chir pmid:8161133
Wang KA et al. Multidimensional narrow bore liquid chromatography analysis of Ro 24-0238 in human plasma. 1994 J Pharm Biomed Anal pmid:8161596
Church DJ et al. Calcium influx in platelet activating factor-induced atrial natriuretic peptide release in rat cardiomyocytes. 1994 Am. J. Physiol. pmid:8166260
Vogels MT et al. Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic mice. 1994 Infect. Immun. pmid:8168971
Kaminskaia GO [Platelet activating factor and its role in pulmonary pathology]. 1994 Probl Tuberk pmid:8170915
Taniguchi S et al. Effects of a platelet-activating factor antagonist at different doses given simultaneously with double-filtration plasmapheresis on cardiac xenograft survival. 1994 Transplant. Proc. pmid:8171719
Spence DP et al. The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma. 1994 Am. J. Respir. Crit. Care Med. pmid:8173754
Pretolani M et al. Role of eosinophil activation in the bronchial reactivity of allergic guinea pigs. 1994 Am. J. Respir. Crit. Care Med. pmid:8173756
McBride DE et al. Inflammatory effects of ozone in the upper airways of subjects with asthma. 1994 Am. J. Respir. Crit. Care Med. pmid:8173759
Pinzani M et al. Biosynthesis of platelet-activating factor and its 1O-acyl analogue by liver fat-storing cells. 1994 Gastroenterology pmid:8174891
Sobhani I et al. Gastric secretion of platelet activating factor and precursors in healthy humans: effect of pentagastrin. 1993 Gut pmid:8174952
Mion F et al. Short term effects of indomethacin on rat small intestinal permeability. Role of eicosanoids and platelet activating factor. 1994 Gut pmid:8174986
Ahmed T et al. Heparin prevents antigen-induced airway hyperresponsiveness: interference with IP3-mediated mast cell degranulation? 1994 J. Appl. Physiol. pmid:8175604
Camussi G Interactive effects of tumor necrosis factor and platelet-activating factor in the pathogenesis of glomerular injury. 1994 Lab. Invest. pmid:8176883
Gómez-Chiarri M et al. Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats. 1994 Lab. Invest. pmid:8176885
Demopoulos CA et al. A simple and precise method for the routine determination of platelet-activating factor in blood and urine. 1994 Lipids pmid:8177023
Barbier A et al. [Microcirculation and rheology]. 1994 Presse Med pmid:8177870
Boyle T et al. Method for simultaneous isolation and quantitation of platelet activating factor and multiple arachidonate metabolites from small samples: analysis of effects of Staphylococcus aureus enterotoxin B in mice. 1994 Anal. Biochem. pmid:8179192
Shirasaki H et al. Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8179916
Blom M et al. Granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3. 1994 Blood pmid:8180394
Smith CS and Shearer WT Activation of NF-kappa B and immunoglobulin expression in response to platelet-activating factor in a human B cell line. 1994 Cell. Immunol. pmid:8181066
Goswami S et al. Characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa). 1994 Jan-Feb Exp. Lung Res. pmid:8181454
Alloatti G et al. Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction. 1994 J. Pharmacol. Exp. Ther. pmid:8182544
Orozco C et al. A description of the basic system of components in pregnant mice sera responsible for 'early pregnancy factor' activity. 1994 J. Reprod. Fertil. pmid:8182603
Tatsumi N et al. An anti-platelet activating factor antibody and its effects on platelet aggregation. 1993 Osaka City Med J pmid:8183536
Ou MC et al. Potential etiologic role of PAF in two major septic complications; disseminated intravascular coagulation and multiple organ failure. 1994 Thromb. Res. pmid:8191415
Imanishi N et al. Biological effects of the new platelet-activating factor receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride. 1994 Arzneimittelforschung pmid:8192697
Cohen RA et al. A platelet-activating factor antagonist reduces corneal allograft inflammation and neovascularization. 1994 Curr. Eye Res. pmid:8194360
Catto-Smith AG et al. Rat gastric motor response to food protein-induced anaphylaxis. 1994 Gastroenterology pmid:8194696
Fukuda A et al. Platelet activating factor enhances the acrosome reaction, fertilization in vitro by subzonal sperm injection and resulting embryonic development in the rabbit. 1994 Hum. Reprod. pmid:8195361
Palmantier R et al. Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. 1994 Lab. Invest. pmid:8196365
Chávez-Cartaya RE et al. Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes. 1994 Transplantation pmid:8197604
Kurosawa M et al. Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms. 1994 Allergy pmid:8198242
Liapikos TA et al. Platelet-activating factor formation during oxidative modification of low-density lipoprotein when PAF-acetylhydrolase has been inactivated. 1994 Biochim. Biophys. Acta pmid:8199206
Hough SR and Parks JE Platelet-activating factor acetylhydrolase activity in seminal plasma from the bull, stallion, rabbit, and rooster. 1994 Biol. Reprod. pmid:8199270
Tamura K et al. The effect of platelet-activating-factor antagonist TCV-309 on arrhythmias and functional recovery during myocardial reperfusion. 1994 Coron. Artery Dis. pmid:8199742
Tashiro H et al. Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances. 1994 Dig. Dis. Sci. pmid:8200255
Ambrosio G et al. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet-activating factor. 1994 J. Clin. Invest. pmid:8200975
Lin CH et al. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by diisoeugenol. 1994 J. Pharm. Pharmacol. pmid:8201527
Bazan NG et al. Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8202477
Rioux KP and Wallace JL Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism. 1994 Am. J. Physiol. pmid:8203531
Sugiura T et al. Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor. 1994 Arch. Biochem. Biophys. pmid:8203898
Nathan N et al. Serum platelet-activating factor acetylhydrolase during coronary artery bypass surgery. 1994 J. Cardiothorac. Vasc. Anesth. pmid:8204819
Kusano K et al. Development of radioimmunoassay for the novel platelet activating factor receptor antagonist, E6123, and its application to pharmacokinetics in laboratory animals. 1994 Biol. Pharm. Bull. pmid:8205134
Simon HU et al. Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma. 1994 J. Immunol. pmid:8207248
Bazan HE et al. Platelet-activating factor antagonists and ocular inflammation. 1994 J Ocul Pharmacol pmid:8207336
Gelbard HA et al. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. 1994 J. Virol. pmid:8207837
Anastasi EM et al. Disposition and metabolism of Ro 24-4736 in the rat. 1994 Life Sci. pmid:8208055
Travis SP and Jewell DP The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8208748
Kald B et al. Phospholipase C from Clostridium perfringens stimulates acetyltransferase-dependent formation of platelet-activating factor in cultured intestinal epithelial cells (INT 407). 1994 Scand. J. Gastroenterol. pmid:8209184
Watson CJ et al. The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival. 1993 Transplantation pmid:8212192
Kusano K et al. Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? 1993 Xenobiotica pmid:8212733
Kusano K et al. Metabolic polymorphism of E6123 in rhesus monkey. 1993 Xenobiotica pmid:8212734
Gaboury J et al. Nitric oxide prevents leukocyte adherence: role of superoxide. 1993 Am. J. Physiol. pmid:8214120
Miyagawa H et al. Density change of neutrophils from allergic subjects by granulocyte-macrophage colony stimulating factor. 1993 Ann Allergy pmid:8214805
Damas J and Prunescu P Presence of immunoreactive platelet-activating factor in peritoneal exudate induced by zymosan in rats. 1993 Mar-Apr Arch Int Pharmacodyn Ther pmid:8215712
Ko FN et al. Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. 1993 Biochem. Pharmacol. pmid:8216367
Tsai JJ et al. Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. 1993 Asian Pac. J. Allergy Immunol. pmid:8216559
Räisänen A et al. Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo. 1993 Transpl. Int. pmid:8216700
Chen ZN et al. [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8216803
Tsoukatos DC et al. Studies on the subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycero phosphocholine (PAF) and on the enzymic activities involved in its biosynthesis within the ciliate Tetrahymena pyriformis. 1993 Biochim. Biophys. Acta pmid:8218344
Weintraub ST et al. Differential electron capture mass spectral response of pentafluorobenzoyl derivatives of platelet activating factor alkyl chain homologs. 1993 Biol. Mass Spectrom. pmid:8218422
Qian C et al. Platelet-activating factor (PAF)-induced cardiopulmonary dysfunctions and their reversal with a PAF antagonist (BN 52021) in strain 13 guinea pigs. 1993 J Lipid Mediat pmid:8219003
Seeds EA et al. The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration. 1993 J Lipid Mediat pmid:8219006
Austin CE and Foreman JC The effect of platelet-activating factor on the responsiveness of the human nasal airway. 1993 Br. J. Pharmacol. pmid:8220870
Katoh S et al. Role of platelet activating factor in ischaemia-reperfusion injury of isolated rabbit hearts: protective effect of a specific platelet activating factor antagonist, TCV-309. 1993 Cardiovasc. Res. pmid:8221795
Hagar AF et al. Endotoxin infusion primes elicited neutrophils and Kupffer cells for platelet-activating factor-induced and tripeptide formyl-methionine-leucine-phenylalanine-induced basal free intracellular calcium concentration responses. 1993 Crit. Care Med. pmid:8222693
Hurst JS and Bazan HE The platelet-activating factor precursor of the injured cornea is selectively implicated in arachidonate and eicosanoid release. 1993 Curr. Eye Res. pmid:8222725
Morita M et al. Inhibitory effects of azelastine hydrochloride on Ca2+ influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1. 1993 Curr Med Res Opin pmid:8222744
Itoh K et al. Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function. 1993 Eur. J. Pharmacol. pmid:8223890
Persico P et al. Protective effect of SV-IV on platelet-activating factor-induced hypotension, bronchoconstriction and gastric mucosal injury. 1993 Eur. J. Pharmacol. pmid:8223928
Garcia Rodriguez C et al. Dissociation of platelet-activating factor production and arachidonate release by the endomembrane Ca(2+)-ATPase inhibitor thapsigargin. Evidence for the involvement of a Ca(2+)-dependent route of priming in the production of lipid mediators by human polymorphonuclear leukocytes. 1993 J. Biol. Chem. pmid:8227034
Silvestro L et al. Development of a high-performance liquid chromatographic-mass spectrometric technique, with an ionspray interface, for the determination of platelet-activating factor (PAF) and lyso-PAF in biological samples. 1993 J. Chromatogr. pmid:8227267
Minor T and Isselhard W Platelet-activating factor antagonism enhances the liver's recovery from warm ischemia in situ. 1993 J. Hepatol. pmid:8228131
Mangino MJ et al. Characterization of platelet-activating factor receptors on canine T lymphocytes. 1993 J. Immunol. pmid:8228226
Teixeira MM et al. Mechanisms of the inflammatory response induced by extracts of Schistosoma mansoni larvae in guinea pig skin. 1993 J. Immunol. pmid:8228243
Jeanneton O et al. Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. 1993 J. Pharmacol. Exp. Ther. pmid:8229757
Müller-Peddinghaus R et al. BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. 1993 J. Pharmacol. Exp. Ther. pmid:8229782
Rocha FA et al. Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry. 1993 J. Rheumatol. pmid:8230022
Houlihan WJ et al. Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. 1993 J. Med. Chem. pmid:8230095
Bull DA et al. Putative vascular endothelial cell chemotactic factors: comparison in a standardized migration assay. 1993 J. Surg. Res. pmid:8231165
Ko W et al. Platelet-activating factor antagonism attenuates platelet and neutrophil activation and reduces myocardial injury during coronary reperfusion. 1993 J. Surg. Res. pmid:8231170
Satouchi K et al. Phospholipids from the free-living nematode Caenorhabditis elegans. 1993 Lipids pmid:8231660
Green PG et al. Further substantiation of a significant role for the sympathetic nervous system in inflammation. 1993 Neuroscience pmid:8232896
Green PG et al. Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint. 1993 Neurosci. Lett. pmid:8233065
MacKendrick W et al. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. 1993 Pediatr. Res. pmid:8233729
Furukawa M et al. Platelet-activating factor-induced ischemic bowel necrosis: the effect of platelet-activating factor acetylhydrolase. 1993 Pediatr. Res. pmid:8233731
Capasso F et al. Effect of senna is not mediated by platelet-activating factor. 1993 Pharmacology pmid:8234442