| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Heptinstall S and Bevan J | How can we inhibit 5-HT-induced platelet aggregation and why should we bother? | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465956 |
| Bodzenta-Lukaszyk A et al. | Blood platelet function in patients with obliterative arteriosclerosis of the lower limbs. | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465957 |
| Terashita Z et al. | Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. | 1988 | J. Cardiovasc. Pharmacol. | pmid:2468048 |
| Smith SK and Kelly RW | Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium. | 1988 | J. Reprod. Fertil. | pmid:3422322 |
| Alessandrì MG et al. | PAF-induced histamine release in the isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:2456276 |
| Martin TR et al. | Pulmonary responses to bronchoconstrictor agonists in the mouse. | 1988 | J. Appl. Physiol. | pmid:2457008 |
| Yoshida K et al. | PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. | 1988 | Prog Biochem Pharmacol | pmid:2457219 |
| Croft KD et al. | Effect of dietary fish oils on the formation of leukotriene B4 and B5, thromboxane and platelet activating factor by rat leukocytes. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:2856061 |
| Anderson G and Fennessy M | Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3145088 |
| Sessler CN et al. | Effects of platelet-activating factor antagonist SRI 63-441 on endotoxemia in sheep. | 1988 | J. Appl. Physiol. | pmid:3145934 |
| Del Monte M and Subissi A | Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3149718 |
| Hofmann B et al. | Effects of synthetic analogues of platelet-activating factor (PAF) on fibrinolytic activity in the rat. | 1988 | Biomed. Biochim. Acta | pmid:3150268 |
| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, of antagonists of the eicosanoids and of PAF on mortality assayed in three biochemically characterized shock models. | 1988 | Biomed. Biochim. Acta | pmid:3150272 |
| Hofmann B et al. | Proaggregatory and inhibitory effects of 2-O-ethyl analogues of platelet-activating factor (PAF) on human and rabbit platelets. | 1988 | Thromb. Res. | pmid:3381200 |
| Rao GH | Measurement of ionized calcium in normal human blood platelets. | 1988 | Anal. Biochem. | pmid:3382012 |
| Banks JB et al. | Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol. | 1988 | Biochim. Biophys. Acta | pmid:3382692 |
| Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
| Miyazawa K et al. | Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. | 1988 | J. Immunol. | pmid:3385211 |
| Archer CB et al. | Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. | 1988 | J. Invest. Dermatol. | pmid:3385217 |
| Taylor RR et al. | Time dependence of whole blood aggregation in response to platelet activating factor (PAF). | 1988 | Thromb. Haemost. | pmid:3388292 |
| Powling MJ and Hardisty RM | Potentiation by adrenaline of Ca2+ influx and mobilization in stimulated human platelets: dissociation from thromboxane generation and aggregation. | 1988 | Thromb. Haemost. | pmid:3388294 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Rosenthal MD et al. | Esterification of 8,11,14-eicosatrienoate and arachidonate into alkylacyl- and diacylglycerophosphocholine by vascular endothelial cells. | 1988 | Lipids | pmid:3148797 |
| Mullane KM et al. | Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837948 |
| Sato N et al. | Microvascular basis of gastric mucosal protection. | 1988 | J. Clin. Gastroenterol. | pmid:3183337 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Mazière JC et al. | PAF-acether decreases low density lipoprotein degradation and alters lipid metabolism in cultured human fibroblasts. | 1988 | FEBS Lett. | pmid:3402608 |
| Hellegouarch A et al. | Effects of BN 52063 and other agents inhibiting platelet-activating factor-induced contractile responses in rat portal vein. | 1988 | J. Pharm. Pharmacol. | pmid:2907020 |
| Subissi A et al. | Effects of anti-asthma drugs on PAF-induced death in mice. | 1988 | Prostaglandins | pmid:2907663 |
| Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
| Smith LJ et al. | Mechanism of platelet activating factor-induced bronchoconstriction in humans. | 1988 | Am. Rev. Respir. Dis. | pmid:3195800 |
| O'Neill C et al. | Embryo-derived platelet-activating factor. Its diagnostic and therapeutic future. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3195924 |
| Ninio E et al. | Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance. | 1988 | Biochim. Biophys. Acta | pmid:3196734 |
| Hsueh W and Gonzalez-Crussi F | Ischemic bowel necrosis induced by platelet-activating factor: an experimental model. | 1988 | Methods Achiev Exp Pathol | pmid:3045496 |
| Kumar R et al. | Production and effects of platelet-activating factor in the rat brain. | 1988 | Biochim. Biophys. Acta | pmid:3196741 |
| Braquet P et al. | Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations. | 1988 | Eur. J. Pharmacol. | pmid:3046952 |
| Bette-Bobillo P and Bienvenue A | Platelet-activating-factor-induced serum-albumin release from rabbit platelets in the absence of calcium. | 1988 | Eur. J. Biochem. | pmid:3197724 |
| Barr R et al. | The effect of platelet activating factor on electron transport of spinach chloroplasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3048258 |
| Cueva JP and Hsueh W | Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. | 1988 | Gut | pmid:3197995 |
| Camussi G et al. | Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases. | 1988 | J. Exp. Med. | pmid:3049910 |
| Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
| Cahill M et al. | Effect of des arginine9-bradykinin and other bradykinin fragments on the synthesis of prostacyclin and the binding of bradykinin by vascular cells in culture. | 1988 | Agents Actions | pmid:3051930 |
| Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
| Page CP et al. | Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs. | 1988 | Agents Actions Suppl. | pmid:3051932 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Janero DR et al. | Specific binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the intact canine platelet. | 1988 | Thromb. Res. | pmid:3413730 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Altman R et al. | Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation. | 1988 | Clin. Pharmacol. Ther. | pmid:3416553 |
| Chu KM et al. | Local vasodilator effect of platelet activating factor in the gastric, mesenteric and femoral arteries of the dog. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3418522 |
| Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
| Weisman SM et al. | Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. | 1988 | Biochem. Pharmacol. | pmid:2840083 |
| Kochanek PM et al. | Cerebrovascular and cerebrometabolic effects of intracarotid infused platelet-activating factor in rats. | 1988 | J. Cereb. Blood Flow Metab. | pmid:3392115 |
| Michel L et al. | Biosynthesis of paf-acether factor-acether by human skin fibroblasts in vitro. | 1988 | J. Immunol. | pmid:3397536 |
| Morrison WJ and Shukla SD | Desensitization of receptor-coupled activation of phosphoinositide-specific phospholipase C in platelets: evidence for distinct mechanisms for platelet-activating factor and thrombin. | 1988 | Mol. Pharmacol. | pmid:2827000 |
| Steel LK et al. | Quantitative, functional and biochemical alterations in the peritoneal cells of mice exposed to whole-body gamma-irradiation. I. Changes in cellular protein, adherence properties and enzymatic activities associated with platelet-activating factor formation and inactivation, and arachidonate metabolism. | 1988 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:3286551 |
| Barnes PJ et al. | Platelet-activating factor as a mediator of allergic disease. | 1988 | J. Allergy Clin. Immunol. | pmid:3286723 |
| Nakayama R and Saito K | [PAF and its physiological significance in normal tissue]. | 1988 | Seikagaku | pmid:3286791 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether (platelet-activating factor). | 1988 | Prog. Clin. Biol. Res. | pmid:3071809 |
| Chung KF et al. | Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man. | 1988 | J. Allergy Clin. Immunol. | pmid:3288683 |
| Lee TC et al. | Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens. | 1988 | J. Biol. Chem. | pmid:2828351 |
| Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
| Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
| Nieto ML et al. | Biosynthesis of platelet-activating factor in human polymorphonuclear leukocytes. Involvement of the cholinephosphotransferase pathway in response to the phorbol esters. | 1988 | J. Biol. Chem. | pmid:2828363 |
| Arnout J et al. | Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man. | 1988 | Br J Clin Pharmacol | pmid:3289599 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Braquet P et al. | Platelet activating factor as a mediator in cerebral ischemia and related disorders. | 1988 | Biomed. Biochim. Acta | pmid:3073761 |
| O'Donnell SR and Barnett CJ | pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. | 1988 | Br. J. Pharmacol. | pmid:3293683 |
| Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
| Esplugues JV and Whittle BJ | Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat. | 1988 | Br. J. Pharmacol. | pmid:3349230 |
| Kobayashi T et al. | Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. | 1988 | Xenobiotica | pmid:3354232 |
| Arnoux B et al. | Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. | 1988 | Am. Rev. Respir. Dis. | pmid:3354991 |
| Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
| Kramer RM et al. | Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | 1988 | Biochim. Biophys. Acta | pmid:3355850 |
| McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
| Abraham WM and Wanner A | Inflammatory mediators of asthma. | 1988 | Pediatr. Pulmonol. | pmid:2455882 |
| Kosano H and Takatani O | Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. | 1988 | Cancer Res. | pmid:3262419 |
| Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
| Morley J et al. | Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor. | 1988 | Agents Actions Suppl. | pmid:3262989 |
| Subissi A and Criscuoli M | Effects of LG 30435 on different platelet activating factor-induced responses. | 1988 | Agents Actions Suppl. | pmid:3262990 |
| Heuer H and Casals-Stenzel J | Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge. | 1988 | Agents Actions Suppl. | pmid:3262991 |
| Ontell SJ et al. | Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441. | 1988 | Gastroenterology | pmid:3263295 |
| Breviario F et al. | IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. | 1988 | J. Immunol. | pmid:3263425 |
| Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
| Altman R et al. | Why single daily dose of aspirin may not prevent platelet aggregation. | 1988 | Thromb. Res. | pmid:3140408 |
| Piper PJ et al. | Release of leukotrienes from porcine and human blood vessels by immunological and nonimmunological stimuli. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837950 |
| Ryan US et al. | Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. | 1988 | J. Appl. Physiol. | pmid:3209566 |
| Nogami M et al. | [Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3210345 |
| Schwertschlag US et al. | Nonimmunological alterations of glomerular filtration by s-PAF in the rat kidney. | 1988 | Kidney Int. | pmid:3210538 |
| Rubin RM and Rosenbaum JT | A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3260779 |
| Fisher RA et al. | AGEPC: a potent calcium-dependent chemical mediator in the liver. | 1988 | Adv. Exp. Med. Biol. | pmid:3213685 |
| Mickelson JK et al. | Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. | 1988 | J. Mol. Cell. Cardiol. | pmid:3216407 |
| Rubin RM et al. | Prostaglandin-independent inhibition of ocular vascular permeability by a platelet-activating factor antagonist. | 1988 | Arch. Ophthalmol. | pmid:3261165 |
| Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
| Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |
| van Delft JL et al. | Specific receptor sites for PAF in iris and ciliary body of the rabbit eye. | 1988 | Curr. Eye Res. | pmid:2854038 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| Shirinsky VP et al. | Agonist-induced polyphosphoinositide breakdown in cultured human endothelial and vascular smooth muscle cells. | 1988 | Health Psychol | pmid:2854052 |
| Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |