| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
| Smith SK and Kelly RW | Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium. | 1988 | J. Reprod. Fertil. | pmid:3422322 |
| Michel L et al. | Release of PAF-acether and precursors during allergic cutaneous reactions. | 1988 | Lancet | pmid:2899817 |
| Frick KK et al. | Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C. | 1988 | J. Biol. Chem. | pmid:2449430 |
| Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
| Dillon PK and Durán WN | Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. | 1988 | Circ. Res. | pmid:2450695 |
| Okuda Y et al. | Histamine release from human leukocytes by platelet-activating factor. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450844 |
| Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
| Spicer BA et al. | Changes in leucocyte numbers without diapedesis in rats given platelet-activating factor (PAF-acether). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2450847 |
| Vercellotti GM et al. | Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. | 1988 | Blood | pmid:2451547 |
| Nasmith PE and Grinstein S | Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. | 1988 | Biosci. Rep. | pmid:2840131 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
| Neuwirth R et al. | Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. | 1988 | J. Clin. Invest. | pmid:3166467 |
| Bratton DL et al. | Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. | 1988 | Biochim. Biophys. Acta | pmid:3370214 |
| Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
| Grue-Sørensen G et al. | Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. | 1988 | J. Med. Chem. | pmid:3373485 |
| Pirotzky E et al. | Protection of platelet-activating factor-induced acute renal failure by BN 52021. | 1988 | Br J Exp Pathol | pmid:3377967 |
| Csatò M and Czarnetzki BM | Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis. | 1988 | Br. J. Dermatol. | pmid:3377969 |
| Hoffman DR et al. | Platelet-activating factor induces glycogen degradation in fetal rabbit lung in utero. | 1988 | J. Biol. Chem. | pmid:3379072 |
| Kertscher HP et al. | [Synthesis and thrombocyte-aggregating action of a structural analog of platelet activating factor with a modified head group]. | 1988 | Pharmazie | pmid:3380866 |
| Achterrath-Tuckermann U et al. | Azelastine, a new antiallergic/antiasthmatic agent, inhibits PAF-acether-induced platelet aggregation, paw edema and bronchoconstriction. | 1988 | Pharmacology | pmid:3380879 |
| Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
| Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
| Handley DA et al. | Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3183958 |
| Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
| Etienne A et al. | Role of neutrophils in gastric damage induced by platelet activating factor. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3244384 |
| Rosenthal MD et al. | Esterification of 8,11,14-eicosatrienoate and arachidonate into alkylacyl- and diacylglycerophosphocholine by vascular endothelial cells. | 1988 | Lipids | pmid:3148797 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Tomooka M et al. | [Azelastine inhibits bronchoconstriction induced by histamine and leukotriene C4]. | 1988 | Arerugi | pmid:2906534 |
| Mazière JC et al. | PAF-acether decreases low density lipoprotein degradation and alters lipid metabolism in cultured human fibroblasts. | 1988 | FEBS Lett. | pmid:3402608 |
| Godfroid JJ and Heymans F | Chemistry of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043433 |
| Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
| Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
| Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
| Ojima-Uchiyama A et al. | Phospholipid analysis of human eosinophils: high levels of alkylacylglycerophosphocholine (PAF precursor). | 1988 | Lipids | pmid:3185116 |
| Skeaff CM and Holub BJ | The effect of fish oil consumption on platelet aggregation responses in washed human platelet suspensions. | 1988 | Thromb. Res. | pmid:3187952 |
| Griffin KJ and Levy JV | The thieno-triazolodiazepine WEB 2086 inhibits platelet aggregation and ATP release from porcine platelets induced by platelet activating factor (PAF). | 1988 | Thromb. Res. | pmid:3187959 |
| Dawson J et al. | Platelet activating factor as a mediator of equine cell locomotion. | 1988 | Vet. Res. Commun. | pmid:3188378 |
| Gay JC and Stitt ES | Enhancement of phorbol ester-induced protein kinase activity in human neutrophils by platelet-activating factor. | 1988 | J. Cell. Physiol. | pmid:3192624 |
| Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
| Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
| Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
| Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
| Stahl GL et al. | Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | 1988 | Eur. J. Pharmacol. | pmid:3409951 |
| Kroegel C et al. | Platelet-activating factor induces eosinophil peroxidase release from purified human eosinophils. | 1988 | Immunology | pmid:3410498 |
| Takizawa H et al. | Bronchoconstriction induced by platelet-activating factor in the guinea pig and its inhibition by CV-3988, a PAF antagonist: serial changes in findings of lung histology and bronchoalveolar lavage cell population. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3410557 |
| Angle MJ et al. | Platelet-activating factor in the rabbit uterus during early pregnancy. | 1988 | J. Reprod. Fertil. | pmid:3411561 |
| Masugi F et al. | Platelet-activating factor and anti-platelet-aggregating factor in acute reduction of blood pressure following percutaneous transluminal renal angioplasty in patients with renovascular hypertension. | 1988 | J Hum Hypertens | pmid:2977405 |
| Kochanek PM et al. | Cerebrovascular and cerebrometabolic effects of intracarotid infused platelet-activating factor in rats. | 1988 | J. Cereb. Blood Flow Metab. | pmid:3392115 |
| Gay JC and Stitt ES | Platelet-activating factor induces protein kinase activity in the particulate fraction of human neutrophils. | 1988 | Blood | pmid:2825844 |
| Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
| Michel L et al. | Biosynthesis of paf-acether factor-acether by human skin fibroblasts in vitro. | 1988 | J. Immunol. | pmid:3397536 |
| Andersson M and Pipkorn U | The effect of platelet activating factor on nasal hypersensitivity. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181276 |
| Adamus WS et al. | Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181277 |
| Yanoshita R et al. | Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases. | 1988 | J. Biochem. | pmid:3182751 |
| Lakin KM | [Problems of a pharmacologic search for inhibitors of platelet aggregation]. | 1988 | Kardiologiia | pmid:3066962 |
| Kawaguchi H et al. | [Effect of platelet-activating factor (PAF) on blood pressure, peripheral, coronary and renovascular system]. | 1988 | Kokyu To Junkan | pmid:3067285 |
| Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
| Lang C and Dobrescu C | Attenuation of burn-induced changes in hemodynamics and glucose metabolism by the PAF antagonist SRI 63-675. | 1988 | Eur. J. Pharmacol. | pmid:3071467 |
| Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
| Whatley RE et al. | The regulation of synthesis of platelet-activating factor by endothelial cells. | 1988 | Chest | pmid:3342689 |
| Ukena D et al. | Radioligand binding of antagonists of platelet-activating factor to intact human platelets. | 1988 | FEBS Lett. | pmid:3342883 |
| Suzuki Y et al. | Release of acetylhydrolase from platelets on aggregation with platelet-activating factor. | 1988 | Eur. J. Biochem. | pmid:3345757 |
| Benveniste J and Leyravaud S | Retention of platelet activating factor by human neutrophils. | 1988 | J. Immunol. | pmid:3346547 |
| Immunomodulation: other approaches. | 1988 | Transplant. Proc. | pmid:3347955 | |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
| 17th annual UCLA symposium. Abstracts: Cell activation and signal initiation: receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production. | 1988 | J. Cell. Biochem. Suppl. | pmid:2835556 | |
| Ostermann G et al. | Structure-activity relationships of synthetic analogues of platelet-activating factor. | 1988 | Biomed. Biochim. Acta | pmid:3248110 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Paulson SK and Nicholson NS | A radioreceptor binding assay for measurement of platelet-activating factor synthesis by human neutrophils. | 1988 | J. Immunol. Methods | pmid:2837517 |
| Stahl GL et al. | Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252036 |
| Williams WR et al. | Plates and anti-asthma drugs. | 1988 | Pneumonol Pol | pmid:3254508 |
| Archer CB | Mediators of heat urticaria. | 1988 | Clin. Exp. Dermatol. | pmid:3256463 |
| Morell GP et al. | Paf-acether (platelet-activating factor) and interleukin-1-like cytokine production by lipopolysaccharide-stimulated glomeruli. | 1988 | Clin. Immunol. Immunopathol. | pmid:3257432 |
| Pignol B et al. | Potentiation of immunosuppressive action of cyclosporine A by platelet-activating factor antagonists: an approach of the mechanism of action of these drugs in the prevention of graft rejection. | 1988 | Transplant. Proc. | pmid:3259039 |
| Bussolino F et al. | Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha. | 1988 | J. Biol. Chem. | pmid:3261295 |
| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
| Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
| Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
| Silva PM et al. | Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats. | 1988 | Braz. J. Med. Biol. Res. | pmid:3240383 |
| Fichelle J et al. | Bronchospasmolytic effects of RU 42173. | 1988 | Fundam Clin Pharmacol | pmid:3240917 |
| Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
| Yasuda K et al. | Acyl type platelet-activating factor in normal rat uterus determined by gas chromatography mass spectrometry. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242662 |
| Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |
| Aratani H et al. | Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. | 1988 | Jpn. J. Pharmacol. | pmid:2848961 |
| Mallet AI | Analysis of lyso-platelet activating factor by negative ion gas chromatography/mass spectrometry of the nitrobenzal acetal derivatives. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242671 |
| Suzuki S et al. | [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. | 1988 | Nihon Jinzo Gakkai Shi | pmid:3244194 |
| Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
| Sueoka K et al. | Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. | 1988 | Am. J. Obstet. Gynecol. | pmid:3207134 |
| Stewart AG and Dusting GJ | Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages. | 1988 | Br. J. Pharmacol. | pmid:2850058 |
| Stahl GL et al. | Detection of platelet-activating factor during traumatic shock. | 1988 | Circ. Shock | pmid:3208421 |
| Korth R et al. | Comparison of three paf-acether receptor antagonist ginkgolides. | 1988 | Eur. J. Pharmacol. | pmid:2850196 |
| Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
| Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
| Chand N et al. | Effect of paf-acether on isoprenaline-induced relaxation in isolated tracheal segments of rats and guinea pigs. | 1988 | Eur. J. Pharmacol. | pmid:2851453 |
| Hayashi H et al. | A novel bioaction of PAF: induction of microbicidal activity in guinea pig bone marrow cells. | 1988 | Lipids | pmid:2852289 |