| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Central Nervous System Diseases | D002493 | 10 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Cerebrovascular Disorders | D002561 | 25 associated lipids |
| Cholecystitis | D002764 | 8 associated lipids |
| Cholestasis | D002779 | 23 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Chromoblastomycosis | D002862 | 2 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Contracture | D003286 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| DeFeudis FV | Studies on endothelium-dependent vasorelaxation. | 1986 | Gen. Pharmacol. | pmid:3512363 |
| Wardlow ML et al. | Substrate specificity and partial characterization of the PAF-acylhydrolase in human serum that rapidly inactivates platelet-activating factor. | 1986 | J. Immunol. | pmid:3514760 |
| Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
| Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
| Ramesha CS and Pickett WC | Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid. | 1986 | J. Biol. Chem. | pmid:3011789 |
| Nunez D et al. | Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. | 1986 | Eur. J. Pharmacol. | pmid:3086108 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Hellewell PG and Williams TJ | A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. | 1986 | J. Immunol. | pmid:2940300 |
| Conrad GW and Rink TJ | Platelet activating factor raises intracellular calcium ion concentration in macrophages. | 1986 | J. Cell Biol. | pmid:3733874 |
| Imura Y et al. | Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988. | 1986 | Life Sci. | pmid:3741541 |
| Kertscher HP and Ostermann G | [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. | 1986 | Pharmazie | pmid:3786385 |
| Touvay C et al. | Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. | 1986 | Immunopharmacology | pmid:3021651 |
| Powling MJ and Hardisty RM | Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2+. | 1986 | Thromb. Res. | pmid:3787566 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Silva PM et al. | Platelet involvement in rat paw edema induced by 2-methoxy-PAF. | 1986 | Inflammation | pmid:3793206 |
| Wu MS et al. | Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3795043 |
| Tetta C et al. | Platelet-activating factor contracts human myometrium in vitro. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3797421 |
| Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Muirhead EE et al. | Renal medullary system of blood pressure control. | 1986 | J Hypertens Suppl | pmid:3534182 |
| Foegh ML et al. | The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats. | 1986 | Pharmacol Res Commun | pmid:3534895 |
| Metz SA | Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release. | 1986 | Diabetes | pmid:3087803 |
| Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
| Okamoto M et al. | Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. | 1986 | Thromb. Res. | pmid:3754990 |
| Zimmerman GA and Klein-Knoeckel D | Human endothelial cells inhibit granulocyte aggregation in vitro. | 1986 | J. Immunol. | pmid:3009611 |
| Villamediana LM et al. | Effects of the platelet-activating factor antagonist BN 52021 on the hemodynamics of rats with experimental cirrhosis of the liver. | 1986 | Life Sci. | pmid:3755490 |
| Garay R and Braquet P | Involvement of K+ movements in the membrane signal induced by PAF-acether. | 1986 | Biochem. Pharmacol. | pmid:3755602 |
| Pfueller SL and David R | Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia. | 1986 | Br. J. Haematol. | pmid:3756098 |
| Hoffman DR et al. | Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. | 1986 | Cancer Res. | pmid:3756924 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Anderson RC et al. | Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. | 1986 | Chem. Phys. Lipids | pmid:3948294 |
| Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
| Hwang SB et al. | Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. | 1986 | Eur. J. Pharmacol. | pmid:3948914 |
| Doyle VM et al. | Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells. | 1986 | FEBS Lett. | pmid:3949010 |
| Wissner A et al. | Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety. | 1986 | J. Med. Chem. | pmid:3950913 |
| Issekutz AC and Szpejda M | Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. | 1986 | Lab. Invest. | pmid:3951199 |
| Shukla SD | Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. | 1986 | Life Sci. | pmid:3951330 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1986 | Bull Eur Physiopathol Respir | pmid:3955269 |
| Phillips ML and Bonjouklian R | Cyclic platelet-activating factor analogues derived from 2-deoxy-D-erythro-pentose. | 1986 | Carbohydr. Res. | pmid:3955572 |
| Schneider E et al. | Transbilayer reorientation of platelet-activating factor in the erythrocyte membrane. | 1986 | FEBS Lett. | pmid:3956740 |
| Thomas MJ et al. | Desorption chemical ionization mass spectrometry of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines and analogues. | 1986 | J. Lipid Res. | pmid:3958619 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
| Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
| Fechter M et al. | Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants. | 1986 | Exp Pathol | pmid:3013671 |
| Patscheke H and Dierichs R | Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. | 1986 | Eur. J. Cell Biol. | pmid:3084260 |
| Billah MM et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation. | 1986 | J. Biol. Chem. | pmid:3084473 |
| Ban C et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. | 1986 | Arch. Biochem. Biophys. | pmid:3963833 |
| Cerletti C et al. | Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. | 1986 | N. Engl. J. Med. | pmid:3941724 |
| Parente L et al. | The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. | 1986 | Agents Actions | pmid:3962774 |
| Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
| Blank ML et al. | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3707974 |
| Tarayre JP et al. | Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. | 1986 | Eur. J. Pharmacol. | pmid:3755401 |
| Kikawa Y et al. | Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. | 1986 | Pediatr. Res. | pmid:3012451 |
| Burhop KE et al. | Platelet-activating factor increases lung vascular permeability to protein. | 1986 | J. Appl. Physiol. | pmid:3804927 |
| Bussolino F et al. | Production of platelet-activating factor by chick retina. | 1986 | J. Biol. Chem. | pmid:3023352 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
| McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
| Yoshida J et al. | A platelet-aggregating and hypotensive phospholipid isolated from bovine brain. | 1986 | J. Pharm. Pharmacol. | pmid:2880959 |
| Mossmann H et al. | Effect of platelet-activating factor on human polymorphonuclear leukocyte enhancement of chemiluminescence and antibody-dependent cellular cytotoxicity. | 1986 | J. Leukoc. Biol. | pmid:3455715 |
| Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
| Di Marzo V et al. | The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs. | 1986 | Biochem. Int. | pmid:2432897 |
| Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
| Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
| Sanchez Crespo M et al. | Evidence of a role for PAF-acether in the pathophysiology of the shock state. | 1986 | Pharmacol Res Commun | pmid:3774844 |
| Adnot S et al. | Interference of BN 52021, a PAF-acether antagonist, with endotoxin-induced hypotension in the guinea-pig. | 1986 | Pharmacol Res Commun | pmid:3774845 |
| Rainsford KD | Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. | 1986 | Pharmacol Res Commun | pmid:3774846 |
| Page CP and Morley J | Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma. | 1986 | Pharmacol Res Commun | pmid:3774847 |
| Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Cordeiro RS et al. | Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. | 1986 | Prostaglandins | pmid:3103172 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Maes L et al. | Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. | 1986 | Pharmacol Res Commun | pmid:3774852 |
| Lee TC et al. | A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. | 1986 | J. Biol. Chem. | pmid:3007498 |
| Handley DA et al. | Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. | 1986 | Thromb. Haemost. | pmid:3775689 |
| Hwang SB and Lam MH | Species difference in the specific receptors of platelet activating factor. | 1986 | Biochem. Pharmacol. | pmid:3024653 |
| Han GQ et al. | [Neolignans from Piper hancei Maxim]. | 1986 | Yao Xue Xue Bao | pmid:3776545 |
| Montrucchio G et al. | Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. | 1986 | Int J Tissue React | pmid:3025124 |
| Hwang SB et al. | Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. | 1986 | J. Biol. Chem. | pmid:3001070 |
| Buxton DB et al. | Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | J. Biol. Chem. | pmid:3001074 |