Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Matsumoto M and Miwa M Platelet-activating factor-binding protein in human serum. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004155
Barnes JL and Venkatachalam MA The role of platelets and polycationic mediators in glomerular vascular injury. 1985 Semin. Nephrol. pmid:2957770
Leid RW and Potter KA Inflammation and mediators of lung injury. 1985 Vet. Clin. North Am. Food Anim. Pract. pmid:3907779
Shukla SD Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. 1985 Arch. Biochem. Biophys. pmid:3875314
Roubin R and Benveniste J Formation of prostaglandins, leukotrienes and paf-acether by macrophages. 1985 Comp. Immunol. Microbiol. Infect. Dis. pmid:3910339
Wasserman SI Mast cell mediators in the blood of patients with asthma. 1985 Chest pmid:3880526
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Sybertz EJ et al. Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. 1985 J. Pharmacol. Exp. Ther. pmid:3917504
Malone B et al. Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. 1985 J. Biol. Chem. pmid:3918041
Juhan-Vague I et al. Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. 1985 Thromb. Res. pmid:3923649
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
MacIntyre DE et al. Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. 1985 FEBS Lett. pmid:2993027
Hayashi H et al. Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. 1985 J. Biochem. pmid:2993272
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Camussi G et al. The role of platelet-activating factor in experimental immune complex pathology. 1985 Int J Tissue React pmid:2932406
Davis JW et al. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. 1985 Clin. Pharmacol. Ther. pmid:3987176
O'Neill C Examination of the causes of early pregnancy-associated thrombocytopenia in mice. 1985 J. Reprod. Fertil. pmid:3989801
Kertscher HP and Ostermann G [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. 1985 Pharmazie pmid:3991788
Wal F et al. PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. 1985 Thromb. Haemost. pmid:3992525
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Otsuka A et al. Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. 1985 Prostaglandins Leukot Med pmid:3862138
Morley J et al. The role of circulating cells in skin reactions. 1985 Br. J. Dermatol. pmid:4015983
Pirotzky E et al. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? 1985 Br. J. Dermatol. pmid:4015984
Ohno M et al. An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. 1985 Chem. Pharm. Bull. pmid:4017109
O'Neill C et al. Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. 1985 J In Vitro Fert Embryo Transf pmid:4020241
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Brain SD and Williams TJ Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. 1985 Br. J. Pharmacol. pmid:2416378
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Weber N and Benning H Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. 1985 Eur. J. Biochem. pmid:3967662
O'Neill C Partial characterization of the embryo-derived platelet-activating factor in mice. 1985 J. Reprod. Fertil. pmid:4067921
Mallet AI and Cunningham FM Structural identification of platelet activating factor in psoriatic scale. 1985 Biochem. Biophys. Res. Commun. pmid:3970690
Valone FH Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). 1985 Biochem. Biophys. Res. Commun. pmid:3970703
Camussi G and Brentjens JR Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. 1985 Clin. Immunol. Immunopathol. pmid:3971603
Chesney CM et al. Desensitization of human platelets by platelet activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:3977920
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Archer CB et al. Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. 1985 Br. J. Dermatol. pmid:3978036
Gerdin B et al. Permeability-increasing ability of PAF-acether in rat skin. 1985 Inflammation pmid:3980073
Ardaillou N et al. Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. 1985 Am. J. Physiol. pmid:3918460
Suemune H et al. Synthetic studies on platelet-activating factor (PAF). 1985 Chem. Pharm. Bull. pmid:4028291
Parente L et al. The release of lyso-PAF from guinea-pig lungs. 1985 Eur. J. Pharmacol. pmid:4029263
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Wissner A et al. Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. 1985 J. Med. Chem. pmid:4032422
Pritchard PH et al. The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). 1985 Blood pmid:4063532
Wissner A et al. Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. 1985 J. Med. Chem. pmid:4032438
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Ludwig JC et al. Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. 1985 Arch. Biochem. Biophys. pmid:4037794
Surles JR et al. Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. 1985 J. Med. Chem. pmid:4038418
Aul C et al. [Thrombotic thrombocytopenic purpura]. 1985 Klin. Wochenschr. pmid:4038757
Hanahan DJ et al. A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. 1985 J. Lipid Res. pmid:4067422
Atkins JN Platelet-aggregating factor in thrombotic thrombocytopenic purpura. 1985 Ann. Intern. Med. pmid:4038861
Pedersen AK and FitzGerald GA Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. 1985 Clin. Pharmacol. Ther. pmid:3917387
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Handley DA et al. Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. 1985 Thromb. Haemost. pmid:4089809
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Hallam TJ et al. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. 1985 Biochem. J. pmid:4091795
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Oda M et al. Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. 1985 J. Immunol. pmid:3917470
Bergelson LD et al. Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. 1985 FEBS Lett. pmid:4043408
Kilpatrick JM and Virella G Inhibition of platelet-activating factor by rabbit C-reactive protein. 1985 Clin. Immunol. Immunopathol. pmid:4042435
Monnens L et al. Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. 1985 Clin. Nephrol. pmid:4042442
Pirotzky E et al. Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. 1985 Agents Actions pmid:4003192
Page CP et al. Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. 1985 Agents Actions pmid:4003195
Page CP et al. Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. 1985 Agents Actions pmid:4003196
Spicer BA et al. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. 1985 Agents Actions pmid:4003197
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Armstrong RA et al. Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. 1985 Prostaglandins pmid:2988022
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
O'Flaherty JT Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE. 1985 J. Cell. Physiol. pmid:2981891
Khan SN et al. Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins. 1985 Eur. J. Pharmacol. pmid:3920056
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
Bushfield M et al. Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. 1985 Biochem. J. pmid:3002327
Orlov SM et al. [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. 1985 Biokhimiia pmid:2408682
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Grandel KE et al. Association of platelet-activating factor with primary acquired cold urticaria. 1985 N. Engl. J. Med. pmid:2410790
Bussolino F et al. Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. 1985 J. Immunol. pmid:2411812
Johnson HM and Torres BA Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2412225
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Fjellner B and Hägermark O Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. 1985 Acta Derm. Venereol. pmid:2416164
Shen TY et al. Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2983307
Avdonin PV and Altukhova IP [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. 1985 Biokhimiia pmid:2416359
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Avdonin PV et al. [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. 1985 Biokhimiia pmid:3000463
Lee TD et al. Heterogeneity in mast cell populations. 1985 Clin Immunol Rev pmid:2417770
Nishihira J et al. Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. 1985 Tohoku J. Exp. Med. pmid:3001971