Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Matsumoto M and Miwa M Platelet-activating factor-binding protein in human serum. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004155
Terashita Z et al. Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004156
Barnes JL and Venkatachalam MA The role of platelets and polycationic mediators in glomerular vascular injury. 1985 Semin. Nephrol. pmid:2957770
Leid RW and Potter KA Inflammation and mediators of lung injury. 1985 Vet. Clin. North Am. Food Anim. Pract. pmid:3907779
Shukla SD Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. 1985 Arch. Biochem. Biophys. pmid:3875314
Roubin R and Benveniste J Formation of prostaglandins, leukotrienes and paf-acether by macrophages. 1985 Comp. Immunol. Microbiol. Infect. Dis. pmid:3910339
Billah MM et al. Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. 1985 Prostaglandins pmid:3936121
Wasserman SI Mast cell mediators in the blood of patients with asthma. 1985 Chest pmid:3880526
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Sybertz EJ et al. Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. 1985 J. Pharmacol. Exp. Ther. pmid:3917504
Harlan JM Leukocyte-endothelial interactions. 1985 Blood pmid:3918593
McKean ML and Silver MJ Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. 1985 Biochem. J. pmid:3919710
Archer CB et al. Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. 1985 Agents Actions pmid:3923788
Malone B et al. Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. 1985 J. Biol. Chem. pmid:3918041
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Camussi G et al. The role of platelet-activating factor in experimental immune complex pathology. 1985 Int J Tissue React pmid:2932406
Benveniste J Biosynthesis and function of PAF-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936197
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Brain SD and Williams TJ Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. 1985 Br. J. Pharmacol. pmid:2416378
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Weber N and Benning H Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. 1985 Eur. J. Biochem. pmid:3967662
O'Neill C Partial characterization of the embryo-derived platelet-activating factor in mice. 1985 J. Reprod. Fertil. pmid:4067921
Mallet AI and Cunningham FM Structural identification of platelet activating factor in psoriatic scale. 1985 Biochem. Biophys. Res. Commun. pmid:3970690
Valone FH Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). 1985 Biochem. Biophys. Res. Commun. pmid:3970703
Camussi G and Brentjens JR Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. 1985 Clin. Immunol. Immunopathol. pmid:3971603
Darius H et al. Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. 1985 J. Pharmacol. Exp. Ther. pmid:2997428
Chesney CM et al. Desensitization of human platelets by platelet activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:3977920
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Archer CB et al. Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. 1985 Br. J. Dermatol. pmid:3978036
Gerdin B et al. Permeability-increasing ability of PAF-acether in rat skin. 1985 Inflammation pmid:3980073
Emeis JJ and Kluft C PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. 1985 Blood pmid:3924144
Ardaillou N et al. Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. 1985 Am. J. Physiol. pmid:3918460
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Wissner A et al. Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. 1985 J. Med. Chem. pmid:4032422
Pritchard PH et al. The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). 1985 Blood pmid:4063532
Wissner A et al. Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. 1985 J. Med. Chem. pmid:4032438
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Ludwig JC et al. Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. 1985 Arch. Biochem. Biophys. pmid:4037794
Surles JR et al. Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. 1985 J. Med. Chem. pmid:4038418
Aul C et al. [Thrombotic thrombocytopenic purpura]. 1985 Klin. Wochenschr. pmid:4038757
Hanahan DJ et al. A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. 1985 J. Lipid Res. pmid:4067422
Atkins JN Platelet-aggregating factor in thrombotic thrombocytopenic purpura. 1985 Ann. Intern. Med. pmid:4038861
Klöcking HP et al. Release of tissue-type plasminogen activator by platelet-activating factor. 1985 Thromb. Res. pmid:4040278
Pedersen AK and FitzGerald GA Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. 1985 Clin. Pharmacol. Ther. pmid:3917387
McManus LM and Pinckard RN Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. 1985 Am. J. Pathol. pmid:4050977
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Oda M et al. Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. 1985 J. Immunol. pmid:3917470
Bergelson LD et al. Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. 1985 FEBS Lett. pmid:4043408
Kilpatrick JM and Virella G Inhibition of platelet-activating factor by rabbit C-reactive protein. 1985 Clin. Immunol. Immunopathol. pmid:4042435
Monnens L et al. Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. 1985 Clin. Nephrol. pmid:4042442
Pirotzky E et al. Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. 1985 Agents Actions pmid:4003192
Page CP et al. Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. 1985 Agents Actions pmid:4003195
Page CP et al. Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. 1985 Agents Actions pmid:4003196
Spicer BA et al. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. 1985 Agents Actions pmid:4003197
Sandler RM et al. Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. 1985 Am. J. Clin. Pathol. pmid:4003343
Tencé M et al. Ether-phospholipid composition in neutrophils and platelets. 1985 Thromb. Res. pmid:4024039
Oda M et al. Production of platelet-activating factor by washed rabbit platelets. 1985 J. Lipid Res. pmid:3934305
Tan EL and Snyder F Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. 1985 Thromb. Res. pmid:4024051
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
O'Flaherty JT Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE. 1985 J. Cell. Physiol. pmid:2981891
Khan SN et al. Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins. 1985 Eur. J. Pharmacol. pmid:3920056
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
Bushfield M et al. Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. 1985 Biochem. J. pmid:3002327
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Grandel KE et al. Association of platelet-activating factor with primary acquired cold urticaria. 1985 N. Engl. J. Med. pmid:2410790
Bussolino F et al. Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. 1985 J. Immunol. pmid:2411812
Johnson HM and Torres BA Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2412225
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Fjellner B and Hägermark O Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. 1985 Acta Derm. Venereol. pmid:2416164
Shen TY et al. Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2983307
Avdonin PV and Altukhova IP [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. 1985 Biokhimiia pmid:2416359
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Avdonin PV et al. [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. 1985 Biokhimiia pmid:3000463
Lee TD et al. Heterogeneity in mast cell populations. 1985 Clin Immunol Rev pmid:2417770
Leclercq M et al. [Effects of Hymenoptera stings: physiopathology and immunology according to recent literature findings]. 1985 Rev Med Liege pmid:2418479
Pipili E Platelet membrane potential: simultaneous measurement of diSC3(5) fluorescence and optical density. 1985 Thromb. Haemost. pmid:2418525
Nishihira J et al. Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. 1985 Tohoku J. Exp. Med. pmid:3001971
Cox CP et al. VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). 1984 Mar-Apr Peptides pmid:6206481
Vemulapalli S et al. Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. 1984 Jul-Aug Hypertension pmid:6378787
Wodzinowska B and Krajewski T [Role of blood platelets and their membrane in the process of hemostasis]. 1984 Jan-Feb Postepy Hig Med Dosw pmid:6093087
Knauer KA et al. Platelet augmentation of IgE-dependent histamine release from human basophils and mast cells. 1984 Int. Arch. Allergy Appl. Immunol. pmid:6200443
Kazimierczak W et al. Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. 1984 Am. Rev. Respir. Dis. pmid:6201094
Fouque F and Vargaftig BB Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. 1984 Br. J. Pharmacol. pmid:6439269
Karlsson G and Pipkorn U Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. 1984 Eur. J. Clin. Pharmacol. pmid:6439565
Doebber TW et al. Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6517949
Heinrich J and Zimmermann RE Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. 1984 Thromb. Res. pmid:6523451
Albert DH and Snyder F Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages. 1984 Biochim. Biophys. Acta pmid:6435681
Lüthje J and Ogilvie A Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. 1984 Biochem. Biophys. Res. Commun. pmid:6704102
Clare KA and Scrutton MC The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). 1984 Eur. J. Biochem. pmid:6705791
Pelczar-Wissner CJ et al. Absence of platelet activating factor (PAF) mediated platelet aggregation: a new platelet defect. 1984 Am. J. Hematol. pmid:6720685