Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
Rubio de Krömer MT et al. | Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. | 1995 | Acta Trop. | pmid:8546035 |
Konstantinov SM et al. | Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. | 1997 | Acta Trop. | pmid:9107362 |
Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
Paubert-Braquet M et al. | Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. | 1990 | Adv. Exp. Med. Biol. | pmid:2173875 |
Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
Rabinovici R et al. | PAF and TNF alpha interactions in the pathophysiology of septic shock. | 1991 | Adv. Exp. Med. Biol. | pmid:1818486 |
Jin N et al. | Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. | 1991 | Adv. Exp. Med. Biol. | pmid:1803920 |