Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chomyszyn-Gajewska M | [Evaluation of chosen salivary periodontal disease markers]. | 2010 | Prz. Lek. | pmid:20687387 |
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| Kordan W et al. | Effect of platelet activating factor (PAF) supplementation in semen extender on viability and ATP content of cryopreserved canine spermatozoa. | 2010 | Pol J Vet Sci | pmid:21370733 |
| Lin S et al. | Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. | 2010 | J. Nat. Prod. | pmid:20961093 |
| He J et al. | The induction of an angiogenic response in corneal myofibroblasts by platelet-activating factor (PAF). | 2010 | Curr. Eye Res. | pmid:20961214 |
| Rechka A et al. | Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis. | 2010 | Can. J. Physiol. Pharmacol. | pmid:20962896 |
| Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
| Garcia CC et al. | Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. | 2010 | PLoS Pathog. | pmid:21079759 |
| de Souza Carmo EV et al. | Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages. | 2010 | PLoS ONE | pmid:21082032 |
| Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
| Nandy D et al. | Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes. | 2010 | J. Cell. Mol. Med. | pmid:19754670 |
| Borthakur A et al. | Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent. | 2010 | Inflamm. Bowel Dis. | pmid:19714753 |
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| Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
| Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
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| Saad MM et al. | Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. | 2010 | Can J Anaesth | pmid:19882198 |
| Chen H et al. | Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. | 2010 | Clin Oral Investig | pmid:19826843 |
| Sreevidya CS et al. | Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. | 2010 | J. Invest. Dermatol. | pmid:19829299 |
| Lautenschläger I et al. | A model of the isolated perfused rat small intestine. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19910525 |
| Yang Y et al. | Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase. | 2010 | Eur. Respir. J. | pmid:19926744 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Coppo R et al. | Aberrantly glycosylated IgA1 induces mesangial cells to produce platelet-activating factor that mediates nephrin loss in cultured podocytes. | 2010 | Kidney Int. | pmid:20016469 |
| Xu Z et al. | Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor. | 2010 | Mol. Ther. | pmid:19953082 |
| Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
| Hasegawa S et al. | Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. | 2010 | PLoS ONE | pmid:20454616 |
| Yang L et al. | Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. | 2010 | J. Biol. Chem. | pmid:20460374 |
| Esquenazi S and Bazan HE | Role of platelet-activating factor in cell death signaling in the cornea: A review. | 2010 | Mol. Neurobiol. | pmid:20431963 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
| Kuebler WM et al. | Vascular barrier regulation by PAF, ceramide, caveolae, and NO - an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature. | 2010 | Cell. Physiol. Biochem. | pmid:20502002 |
| Wang L et al. | Three new compounds from Morus nigra L. | 2010 | J Asian Nat Prod Res | pmid:20552479 |
| Lu J et al. | Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. | 2010 | Pediatr. Res. | pmid:20531249 |
| Kim DD et al. | Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo. | 2010 | Microcirculation | pmid:20163539 |
| Yost CC et al. | The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. | 2010 | Biochimie | pmid:20167241 |
| Sharif NA and Wiernas TK | Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells. | 2010 | J Ocul Pharmacol Ther | pmid:20187806 |
| Metz M et al. | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. | 2010 | Ann. Allergy Asthma Immunol. | pmid:20143651 |
| Xiping Z et al. | Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis. | 2010 | Inflammation | pmid:20127399 |
| Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
| Moriguchi S et al. | Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. | 2010 | Neuroscience | pmid:20074623 |
| Zhou X and He P | Endothelial [Ca2+]i and caveolin-1 antagonistically regulate eNOS activity and microvessel permeability in rat venules. | 2010 | Cardiovasc. Res. | pmid:20080986 |
| Kenchegowda S and Bazan HE | Significance of lipid mediators in corneal injury and repair. | 2010 | J. Lipid Res. | pmid:19965607 |
| Jørgensen KM et al. | Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2. | 2010 | Arch. Dermatol. Res. | pmid:20041255 |
| Coy Barrera ED and Cuca Suárez LE | In vitro inhibitory activities of Lauraceae aporphine alkaloids. | 2010 | Nat Prod Commun | pmid:20420312 |
| Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
| Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |
| Grassi G et al. | Exogenous platelet-activating factor improves the motility of human spermatozoa evaluated with C.A.S.A.: optimal concentration and incubation time. | 2010 | J. Endocrinol. Invest. | pmid:20220291 |
| Binder U et al. | The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans. | 2010 | Mol. Microbiol. | pmid:19889092 |
| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
| Peng SY et al. | [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. | 2010 | Yao Xue Xue Bao | pmid:21351565 |
| Mrówczyńska L and Hägerstrand H | Platelet-activating factor interaction with the human erythrocyte membrane. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827129 |
| Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
| Steel HC et al. | Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation. | 2009 | J. Antimicrob. Chemother. | pmid:19744985 |
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Musio S et al. | Anaphylaxis to a self-peptide in the absence of mast cells or histamine. | 2009 | Lab. Invest. | pmid:19188909 |
| Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. | 2009 | Mol. Pharmacol. | pmid:18931035 |
| McIntyre TM et al. | The emerging roles of PAF acetylhydrolase. | 2009 | J. Lipid Res. | pmid:18838739 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Brooks AC et al. | Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290950 |
| Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
| Melnikova VO and Bar-Eli M | Inflammation and melanoma metastasis. | 2009 | Pigment Cell Melanoma Res | pmid:19368690 |
| Sánchez FA et al. | Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19342481 |
| Marotta DM et al. | Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. | 2009 | Biochem. Pharmacol. | pmid:19283893 |
| Yost CC et al. | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. | 2009 | Blood | pmid:19221037 |
| Tsoupras AB et al. | The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. | 2009 | Infect Disord Drug Targets | pmid:19689381 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Wijman CA | Is platelet activity important in acute intracerebral hemorrhage? | 2009 | Neurocrit Care | pmid:19714496 |
| Rehse K et al. | New 1H-pyrazole-4-carboxamides with antiplatelet activity. | 2009 | Arch. Pharm. (Weinheim) | pmid:19051198 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Detopoulou P et al. | Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. | 2009 | Clin. Biochem. | pmid:18955040 |
| Giannattasio G et al. | Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. | 2009 | Biochim. Biophys. Acta | pmid:19130898 |
| Khodoun M et al. | Peanuts can contribute to anaphylactic shock by activating complement. | 2009 | J. Allergy Clin. Immunol. | pmid:19121857 |
| Plager DA et al. | Pimecrolimus reduces eosinophil activation associated with calcium mobilization. | 2009 | Int. Arch. Allergy Immunol. | pmid:19127068 |
| Severino DN et al. | Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms. | 2009 | Inflammation | pmid:19096919 |
| Mukai K et al. | New insights into the roles for basophils in acute and chronic allergy. | 2009 | Allergol Int | pmid:19153532 |
| Eigenmann PA | Mechanisms of food allergy. | 2009 | Pediatr Allergy Immunol | pmid:19154253 |
| Knezevic II et al. | Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. | 2009 | J. Biol. Chem. | pmid:19095647 |
| Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Kovacova E et al. | General changes in hemostasis in gastric cancer. | 2009 | Bratisl Lek Listy | pmid:19507648 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Tang WZ et al. | Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19496609 |
| Hakim-Rad K et al. | Mast cells: makers and breakers of allergic inflammation. | 2009 | Curr Opin Allergy Clin Immunol | pmid:19550301 |
| Li Y et al. | Activation of a chloride channel by a trophic ligand is required for development of the mouse preimplantation embryo in vitro. | 2009 | Biol. Reprod. | pmid:19553604 |
| Deng Y et al. | Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. | 2009 | Eur. J. Pharmacol. | pmid:19555682 |
| Edwards LJ and Constantinescu CS | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. | 2009 | Inflamm Allergy Drug Targets | pmid:19601878 |
| Tung JP et al. | Respiratory burst function of ovine neutrophils. | 2009 | BMC Immunol. | pmid:19422720 |
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| Di Leo E et al. | Treatment of acquired cold urticaria with rupatadine. | 2009 | Allergy | pmid:19392988 |
| Chang W et al. | Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. | 2009 | Exp. Lung Res. | pmid:19415549 |
| Mayerle J | A novel role for leucocytes in determining the severity of acute pancreatitis. | 2009 | Gut | pmid:19834113 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Dorfman AL et al. | The effect of oxygen and light on the structure and function of the neonatal rat retina. | 2009 | Doc Ophthalmol | pmid:18483821 |
| Keating FK and Schneider DJ | The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. | 2009 | J. Thromb. Thrombolysis | pmid:18574670 |
| Zhang X et al. | Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. | 2009 | Pancreas | pmid:19657312 |
| Zhang Q et al. | Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia. | 2009 | J. Invest. Dermatol. | pmid:18580961 |