Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| McFall TL et al. | Effect of group B streptococcal type-specific antigen on polymorphonuclear leukocyte function and polymorphonuclear leukocyte-endothelial cell interaction. | 1987 | Pediatr. Res. | pmid:3037472 |
| Hecker G et al. | Potent inhibition of PAF-stimulated human platelets and polymorphonuclear leukocytes by the PGE1 analog OP-1206. | 1987 | Prog. Clin. Biol. Res. | pmid:2444988 |
| Desquand S et al. | Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2445183 |
| Kurosawa M | Effect of platelet activating factor on histamine release from rat mast cells. | 1987 | Agents Actions Suppl. | pmid:2445185 |
| Gerard NP | Characterization of substance P contractile activity on isolated guinea pig lung tissues. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447271 |
| Alam I and Silver MJ | Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin. | 1987 | Thromb. Res. | pmid:3576519 |
| Kusner EJ et al. | Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat. | 1987 | Agents Actions | pmid:3577957 |
| Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
| Chesney CM et al. | Triazolobenzodiazepines competitively inhibit the binding of platelet activating factor (PAF) to human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579913 |
| Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
| Casals-Stenzel J | Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock. | 1987 | Eur. J. Pharmacol. | pmid:3582490 |
| Fouque F and Vargaftig BB | Potentiation and inhibition by clonidine of PAF-acether-induced human platelet activation. | 1987 | Eur. J. Pharmacol. | pmid:3582495 |
| Lellouch-Tubiana A et al. | Interactions between granulocytes and platelets with the guinea-pig lung in passive anaphylactic shock. Correlations with PAF-acether-induced lesion. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3583412 |
| Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Criscuoli M and Subissi A | Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:2880624 |
| Adamson LM et al. | Mechanistic studies of early pregnancy associated thrombocytopenia (EPAT) in the mouse. | 1987 | Am J Reprod Immunol Microbiol | pmid:3605486 |
| Sugiura T et al. | Transacylation of lyso platelet-activating factor and other lysophospholipids by macrophage microsomes. Distinct donor and acceptor selectivities. | 1987 | J. Biol. Chem. | pmid:3805017 |
| Edwards MC et al. | Secretion and properties of a polypeptide factor generated by phorbol ester stimulation of human blood platelets. | 1987 | Biochem. Pharmacol. | pmid:3606649 |
| Sturk A et al. | Platelet-activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet-activating factor synthesis. | 1987 | J. Clin. Invest. | pmid:3805272 |
| Sturk A et al. | Age-related deficiency of the synthesis of platelet activating factor by leukocytes from Zellweger patients. | 1987 | Blood | pmid:3607283 |
| Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
| Martins MA et al. | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. | 1987 | Eur. J. Pharmacol. | pmid:3609124 |
| Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
| Casals-Stenzel J | Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis. | 1987 | Immunopharmacology | pmid:3597059 |
| Handley DA et al. | Biological properties of the antagonist SRI 63-441 in the PAF and endotoxin models of hypotension in the rat and dog. | 1987 | Immunopharmacology | pmid:3597060 |
| Casals-Stenzel J et al. | Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3598913 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor. | 1987 | Thromb. Res. | pmid:3647677 |
| Dewald B and Baggiolini M | Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. | 1987 | Biochem. Pharmacol. | pmid:3649232 |
| Adler KB et al. | Platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture. | 1987 | Exp. Lung Res. | pmid:3653044 |
| Nakayama R et al. | Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus. | 1987 | J. Biol. Chem. | pmid:3654606 |
| Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Kudo I et al. | Antitumor activity of synthetic alkylphospholipids with or without PAF activity. | 1987 | Lipids | pmid:3444379 |
| Söling U et al. | Effect of synthetic phospholipids on platelet aggregation and serotonin release. | 1987 | Lipids | pmid:3444380 |
| Schick HD et al. | Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. | 1987 | Lipids | pmid:3444383 |
| Danhauser S et al. | Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro. | 1987 | Lipids | pmid:3444384 |
| Oon SH and Williams N | Immature megakaryocytes in the mouse: synergistic response to megakaryocyte potentiator, thrombopoietic stimulatory factor with interleukin 3. | 1987 | Leukemia | pmid:3500375 |
| Neuwirth R et al. | Effect of platelet activating factor antagonists on cultured rat mesangial cells. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3119816 |
| Fennessy MR et al. | Lipid mediators of anaphylaxis and increased airways reactivity. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:2824102 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Barnes PJ | New concepts in the pathogenesis of bronchial hyperresponsiveness. | 1987 | Agents Actions Suppl. | pmid:3314413 |
| Mustard JF et al. | Platelet activation--an overview. | 1987 | Agents Actions Suppl. | pmid:3314414 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Page CP and Robertson DN | Properties of PAF relevant to asthma. | 1987 | Agents Actions Suppl. | pmid:3314416 |
| Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
| Morley J | PAF and airway hyperreactivity; prospects for novel prophylactic anti-asthma drugs. | 1987 | Agents Actions Suppl. | pmid:3314417 |
| Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
| Braquet P et al. | The role of PAF-acether in anaphylaxis demonstrated with the use of the antagonist BN 52021. | 1987 | Agents Actions Suppl. | pmid:3314418 |
| Rubin AH et al. | The bronchoconstrictor properties of platelet-activating factor in humans. | 1987 | Am. Rev. Respir. Dis. | pmid:3314611 |
| Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
| Chabot MC et al. | Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils. | 1987 | Biochim. Biophys. Acta | pmid:2823907 |
| HÃ¥kansson L et al. | New method for the measurement of eosinophil migration. | 1987 | J. Leukoc. Biol. | pmid:2445885 |
| Sciberras DG et al. | Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation. | 1987 | Br J Clin Pharmacol | pmid:2449904 |
| Lecrubier C et al. | [Platelet aggregation tests in 26 cases of heparin-induced thrombopenia. Methodological, diagnostic problems and therapeutic aspects]. | 1987 | J Mal Vasc | pmid:2834484 |
| Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
| Steiger J et al. | Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro. | 1987 | Eur. J. Pharmacol. | pmid:3428351 |
| Karasawa K et al. | Antibody to platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF). | 1987 | J. Biochem. | pmid:3429442 |
| Stahl GL et al. | PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3431598 |
| Spinnewyn B et al. | Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. | 1987 | Prostaglandins | pmid:3432553 |
| Guinot P et al. | Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. | 1987 | Prostaglandins | pmid:3432562 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
| Hayashi M et al. | Detection of platelet-activating factor in exudates of rats with phorbol myristate acetate-induced pleurisy. | 1987 | Thromb. Res. | pmid:3433255 |
| Sudan BJ | Ketoconazole, leukotrienes, Paf-acether and nicotine as a hapten: the possible aetiology of seborrhoeic dermatitis. | 1987 | Med. Hypotheses | pmid:2886895 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Ostermann G et al. | Modification of the polar head group of platelet-activating factor: influence on the biological activity. | 1987 | Chem. Phys. Lipids | pmid:3607969 |
| Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
| Sugatani J et al. | Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation. | 1987 | J. Biol. Chem. | pmid:2824509 |
| McIntyre TM et al. | Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils. | 1987 | J. Biol. Chem. | pmid:2824456 |
| Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
| Sperling RI et al. | The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. | 1987 | J. Immunol. | pmid:2826583 |
| Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
| Sisson JH et al. | Production of platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism. | 1987 | J. Immunol. | pmid:3035016 |
| Michel L et al. | Biologic properties of LTB4 and paf-acether in vivo in human skin. | 1987 | J. Invest. Dermatol. | pmid:3035030 |
| PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986. | 1987 | Agents Actions Suppl. | pmid:3478993 | |
| Farr RS et al. | Platelet abnormalities in asthma--do they exist in humans? | 1987 | Agents Actions Suppl. | pmid:3478994 |
| Menz G et al. | Lack of PAF release in extrinsic asthma. | 1987 | Agents Actions Suppl. | pmid:3478995 |
| Szczeklik A et al. | Bleeding time and PAF-acether-induced platelet aggregation in atopy. | 1987 | Agents Actions Suppl. | pmid:3478996 |
| Schmitz-Schumann M et al. | Evidence of PAF release and platelet activation in analgesics-asthma-syndrome. | 1987 | Agents Actions Suppl. | pmid:3478999 |
| Guinot P et al. | Effects of BN 52063 on PAF-acether induced weal and flare in man. | 1987 | Agents Actions Suppl. | pmid:3479000 |
| Lang M et al. | Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | Agents Actions Suppl. | pmid:3479001 |
| Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |
| Sweatt JD et al. | Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. | 1987 | Circ. Res. | pmid:2822286 |
| Kurgan J | [Blood platelets and asthma and other lung diseases]. | 1987 | Pol Tyg Lek | pmid:3684765 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Nishihira J and Ishibashi T | A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. | 1986 | Lipids | pmid:3821393 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |