Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
Luu NT et al. | Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. | 2000 | J. Immunol. | pmid:10820279 |
Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
Kulikov VI and Muzya GI | Bioactive amide of prostaglandin E1 and ethanolamine plasmalogen analog of platelet-activating factor inhibits several pathways of human platelet aggregation. | 2000 | Biochemistry Mosc. | pmid:10810178 |
Kosaka T et al. | Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | 2000 | Clin. Chim. Acta | pmid:10807978 |
Dearn S et al. | Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. | 2000 | Mol. Med. | pmid:10803407 |
Balsinde J et al. | Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. | 2000 | J. Immunol. | pmid:10799904 |
Asai Y and Watanabe S | Characterization of the physicochemical properties of the micelles by the novel platelet activating factor receptor antagonist E5880. | 2000 | Eur J Pharm Biopharm | pmid:10799812 |
Oshiro T et al. | Characterization of platelet-activating factor-induced cytosolic calcium mobilization in human eosinophils. | 2000 | Clin. Exp. Allergy | pmid:10792362 |
Asai Y et al. | A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements. | 2000 | Drug Dev Ind Pharm | pmid:10789068 |
Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
Hauser CJ et al. | Major trauma enhances store-operated calcium influx in human neutrophils. | 2000 | J Trauma | pmid:10780589 |
Shute J | Signal transduction mechanisms in human eosinophils. | 1993 | Clin. Exp. Allergy | pmid:10779300 |
Sehmi R et al. | Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects. | 1993 | Clin. Exp. Allergy | pmid:10779297 |
Lagente V et al. | Effects of the platelet activating factor antagonists BN 52021 and BN 50730 on antigen-induced bronchial hyperresponsiveness and eosinophil infiltration in lung from sensitized guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10779293 |
Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
Connolly AB and Vernon DR | Manipulations of the metabolic response for management of patients with severe surgical illness: review. | 2000 | World J Surg | pmid:10773122 |
Munakata M et al. | Nafamostat mesilate modulates the release of platelet-activating factor during left ventricular assistance with hemofiltration in canine heart failure. | 2000 | Jpn. J. Thorac. Cardiovasc. Surg. | pmid:10769990 |
Emerson M et al. | Characterization and functional significance of calcium transients in the 2-cell mouse embryo induced by an autocrine growth factor. | 2000 | J. Biol. Chem. | pmid:10764773 |
Triggiani M et al. | Metabolism of lipid mediators in human eosinophils. | 2000 | Chem. Immunol. | pmid:10761306 |
Kalia N et al. | Mechanisms of Helicobacter pylori-induced rat gastric mucosal microcirculatory disturbances in vivo. | 2000 | Dig. Dis. Sci. | pmid:10759248 |
Liao CH et al. | Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. | 2000 | J. Pharm. Pharmacol. | pmid:10757426 |
Cijevschi I and Cijevschi D | [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. | 1999 Jan-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:10756889 |
Bailey SR et al. | Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. | 2000 | Res. Vet. Sci. | pmid:10756136 |
Lendvai N et al. | Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus neoformans-infected mice. | 2000 | J. Immunol. | pmid:10754337 |
Vincent JL et al. | Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. | 2000 | Crit. Care Med. | pmid:10752807 |
Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
Koyama S et al. | The potential of various lipopolysaccharides to release IL-8 and G-CSF. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749742 |
Ibe BO et al. | Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749711 |
Ruchaud-Sparagano MH et al. | Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization. | 2000 | J. Biol. Chem. | pmid:10748085 |
Howard KM and Olson MS | The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. | 2000 | J. Biol. Chem. | pmid:10748027 |
Wiese A et al. | Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity. | 2000 | Biol. Chem. | pmid:10746745 |
Tan XD et al. | Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. | 2000 | Br. J. Pharmacol. | pmid:10742310 |
Hagi A et al. | Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor. | 2000 | J. Med. Invest. | pmid:10740976 |
Boccellino M et al. | Effect of platelet-activating factor receptor expression on CHO cell motility. | 2000 | J. Cell. Physiol. | pmid:10737901 |
Desplat V et al. | Metabolism and effect of platelet-activating factor on the growth of human myeloma cell lines. | 2000 | Cancer Lett. | pmid:10737702 |
Berthou C et al. | Interferon-gamma-induced membrane PAF-receptor expression confers tumor cell susceptibility to NK perforin-dependent lysis. | 2000 | Blood | pmid:10733503 |
Schmidt J et al. | Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer. | 1999 | Int. J. Pancreatol. | pmid:10732294 |
Iglesias-De La Cruz MC et al. | Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species. | 2000 Mar-Apr | Exp. Nephrol. | pmid:10729749 |
Ishii S and Shimizu T | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. | 2000 | Prog. Lipid Res. | pmid:10729607 |
Wang WZ et al. | Platelet-activating factor contributes to postischemic vasospasm. | 2000 | J. Surg. Res. | pmid:10729242 |
Vallee RB et al. | The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. | 2000 | Biochim. Biophys. Acta | pmid:10722879 |
Sun Z et al. | Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats. | 2000 | Dig Surg | pmid:10720833 |
Manabe H et al. | The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs. | 2000 | Pulm Pharmacol Ther | pmid:10718985 |
Chen LW et al. | Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. | 2000 | Shock | pmid:10718373 |
Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
Turner PJ et al. | Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10711351 |
Nikbakht-Sangari M et al. | The role of inflammatory mediators in the mechanism of the host immune response induced by ischemia-reperfusion injury. | 2000 | Immunol. Invest. | pmid:10709843 |
Neuberger Y et al. | A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. | 2000 | FEBS Lett. | pmid:10708753 |
Fukuda Y et al. | Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models. | 2000 | Eur. J. Pharmacol. | pmid:10708725 |
Henderson WR et al. | Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. | 2000 | J. Immunol. | pmid:10706731 |
Hidi R et al. | Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis. | 2000 | Eur. Respir. J. | pmid:10706503 |
Tremblay G | BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1999 | Mediators Inflamm. | pmid:10704058 |
Zouki C et al. | The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells. | 2000 | FASEB J. | pmid:10698973 |
Emingil G et al. | Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. | 2000 | J. Periodontol. | pmid:10695938 |
De Plaen IG et al. | Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. | 2000 | Br. J. Pharmacol. | pmid:10694237 |
Nilsson G et al. | Demonstration that platelet-activating factor is capable of activating mast cells and inducing a chemotactic response. | 2000 | Immunology | pmid:10692052 |
Weintraub ST et al. | Mass spectrometric analysis of platelet-activating factor after isolation by solid-phase extraction and direct derivatization with pentafluorobenzoic anhydride. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689672 |
Bleeker WK et al. | Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. | 2000 | Blood | pmid:10688848 |
Werr J et al. | Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. | 2000 | Blood | pmid:10688841 |
Sugano T et al. | Platelet-activating factor induces an imbalance between matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 expression in human uterine cervical fibroblasts. | 2000 | Biol. Reprod. | pmid:10684793 |
Fujimura M et al. | No involvement of lipid mediators in a guinea pig model of ultrasonically nebulized distilled water-induced bronchoconstriction. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10680775 |
Ishihara Y et al. | Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. | 2000 | Infect. Immun. | pmid:10678975 |
Orozco AS et al. | Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection. | 2000 | Infect. Immun. | pmid:10678917 |
Kimura I et al. | Release of endothelins and platelet-activating factor by a rat pleural mesothelial cell line. | 2000 | Eur. Respir. J. | pmid:10678641 |
Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
Burgermeister E et al. | Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells. | 2000 | Eur. J. Pharmacol. | pmid:10675727 |
Cowling RT and Birnboim HC | Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. | 2000 | J. Leukoc. Biol. | pmid:10670586 |
Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
Yu R et al. | Studies on the callus cultures of Ginkgo biloba and its metabolites-ginkgolides. | 1999 | Chin. J. Biotechnol. | pmid:10668135 |
Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
Ibe BO et al. | Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. | 2000 | Mol. Genet. Metab. | pmid:10655157 |
Dichmann S et al. | Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. | 2000 | Blood | pmid:10648411 |
Miike S et al. | Platelet-activating factor activates mitogen-activated protein kinases through the activation of phosphatidylinositol 3-kinase and tyrosine kinase in human eosinophils. | 2000 | J. Leukoc. Biol. | pmid:10648006 |
Michibayashi T | Interaction between platelet-aggregating response and vasoconstrictive response to platelet activating factor. | 1999 | J Smooth Muscle Res | pmid:10647808 |
Munir I et al. | Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B. | 1999 | J. Reprod. Fertil. | pmid:10645245 |
Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
Clavijo LC et al. | Platelet-activating factor and bacteremia-induced pulmonary hypertension. | 2000 | J. Surg. Res. | pmid:10644485 |
Tong N et al. | Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. | 2000 | J. Immunol. | pmid:10640747 |
Chlopicki S et al. | Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. | 1999 | J. Physiol. Pharmacol. | pmid:10639006 |
Keularts IM et al. | alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. | 2000 | J. Biol. Chem. | pmid:10636873 |
Atuma C et al. | Helicobacter pylori extracts reduce gastric mucosal blood flow by a nitric oxide-independent but mast cell- and platelet-activating factor receptor-dependent pathway in rats. | 1999 | Scand. J. Gastroenterol. | pmid:10636064 |
Montrucchio G et al. | Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10634803 |
Haines DD et al. | Cardioprotective effects of the calcineurin inhibitor FK506 and the PAF receptor antagonist and free radical scavenger, EGb 761, in isolated ischemic/reperfused rat hearts. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10630731 |
Franke B et al. | Sequential regulation of the small GTPase Rap1 in human platelets. | 2000 | Mol. Cell. Biol. | pmid:10629034 |
Kaul DK et al. | Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. | 2000 | Blood | pmid:10627437 |
Kim DD et al. | Platelet-activating factor modulates microvascular dynamics through phospholipase C in the hamster cheek pouch. | 2000 | Microvasc. Res. | pmid:10625566 |
Fukuda S et al. | Mechanisms for regulation of fluid shear stress response in circulating leukocytes. | 2000 | Circ. Res. | pmid:10625314 |