Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Sibelius U et al. | Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. | 2000 Jan 4-11 | Circulation | pmid:10618308 |
Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
Sawai H et al. | Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. | 1999 | J. Biol. Chem. | pmid:10608884 |
Hashimoto S et al. | p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10606930 |
Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
Wechsung E and Houvenaghel A | Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10597537 |
Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
Burns AR et al. | Analysis of tight junctions during neutrophil transendothelial migration. | 2000 | J. Cell. Sci. | pmid:10591624 |
Kitsiouli EI et al. | Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. | 1999 | J. Lipid Res. | pmid:10588961 |
Kafoury RM et al. | Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588609 |
Byrum RS et al. | Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. | 1999 | J. Immunol. | pmid:10586081 |
Hendrickson HS et al. | Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. | 1999 | Anal. Biochem. | pmid:10585741 |
Wu R et al. | Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome. | 1999 | J. Intern. Med. | pmid:10583710 |
Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
Shin BA et al. | Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. | 1999 | J. Nat. Prod. | pmid:10579872 |
Mizuki M et al. | Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor. | 1999 | Life Sci. | pmid:10579457 |
Goldfarb R | Investigations into the polydeterminant nature of sepsis. | 1999 | Crit. Care Med. | pmid:10579296 |
Quinn JV and Slotman GJ | Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock. | 1999 | Crit. Care Med. | pmid:10579269 |
Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
Olszanecki R and Chłopicki S | Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia. | 1999 | J. Physiol. Pharmacol. | pmid:10574473 |
Tekgül H et al. | Lymphocyte subsets and inflammatory mediators in patients with subacute sclerosing panencephalitis. | 1999 | J. Child Neurol. | pmid:10573462 |
Grutters JC et al. | Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. | 1999 | Eur. Respir. J. | pmid:10573242 |
Bratt T et al. | Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. | 1999 | Biochim. Biophys. Acta | pmid:10572948 |
Torras J et al. | Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. | 1999 | Kidney Int. | pmid:10571788 |
Ozaki N et al. | Mechanosensitive properties of gastric vagal afferent fibers in the rat. | 1999 | J. Neurophysiol. | pmid:10561400 |
Fuentes E et al. | Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes. | 1999 | Glia | pmid:10559786 |
Lauener RW et al. | A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. | 1999 | Biochim. Biophys. Acta | pmid:10559473 |
Falk S et al. | Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10556149 |
Adunsky A et al. | Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke. | 1999 | Neurol. Res. | pmid:10555184 |
Wang MM et al. | Stereoselective actions of hepoxilins A3 and B3 and their cyclopropane analogs (HxdeltaA3 and HxdeltaB3) on bradykinin and PAF-evoked potentiation of vascular leakage in rat skin. | 1999 | Gen. Pharmacol. | pmid:10553878 |
Biancone L et al. | Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. | 1999 | Am. J. Pathol. | pmid:10550329 |
Li S et al. | Experimental therapy of a platelet-activating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews. | 1999 | Clin. Exp. Pharmacol. Physiol. | pmid:10549411 |
Uluoglu C and Timlioglu O | Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia and reperfusion: effects of antagonizing platelet activating factor (PAF). | 1999 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10543435 |
Gómez FP et al. | Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study. | 1999 | Eur. Respir. J. | pmid:10543285 |
Echazarreta AL et al. | Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. | 1999 | Eur. Respir. J. | pmid:10543284 |
Koyama S et al. | The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. | 1999 | Eur. Respir. J. | pmid:10543273 |
Manya H et al. | Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase. | 1999 | J. Biol. Chem. | pmid:10542206 |
Ernest S and Bello-Reuss E | Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10541289 |
Tselepis AD et al. | Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: effect of c7E3 Fab (abciximab) therapy. | 1999 | Cardiovasc. Res. | pmid:10536703 |
McKenna CJ et al. | Familial dilated cardiomyopathy. | 1999 | Circulation | pmid:10534480 |
Nicholson SC et al. | Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. | 1999 | J. Surg. Res. | pmid:10534424 |
Mustafa SB et al. | Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. | 1999 | Hepatology | pmid:10534342 |
Serou MJ et al. | Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. | 1999 | J. Neurosci. Res. | pmid:10533051 |
Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
Stammberger U et al. | Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. | 1999 | J. Heart Lung Transplant. | pmid:10528748 |
Vergnolle N | Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. | 1999 | J. Immunol. | pmid:10528212 |
Sun Z et al. | Roles of platelet-activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. | 1999 | J. Surg. Res. | pmid:10527709 |
Kinlough-Rathbone RL et al. | Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. | 1999 | Thromb. Res. | pmid:10527409 |
Wang X et al. | Platelet-activating factor induced Ca(2+) signaling in human microglia. | 1999 | Brain Res. | pmid:10526106 |
Nagase T et al. | Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. | 1999 | J. Clin. Invest. | pmid:10525045 |
Prescott SM et al. | Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. | 1999 | J. Clin. Invest. | pmid:10525039 |
Monteiro HS et al. | Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. | 1999 | Pharmacol. Toxicol. | pmid:10522748 |
Hocke M et al. | Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. | 1999 Jul-Aug | Hepatogastroenterology | pmid:10521992 |
Sugiura T et al. | Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. | 1999 | Biochim. Biophys. Acta | pmid:10521703 |
Bernatchez PN et al. | Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. | 1999 | J. Biol. Chem. | pmid:10521504 |
Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
Tiemann U et al. | Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. | 1999 | J. Reprod. Fertil. | pmid:10505057 |
Min JH et al. | Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. | 1999 | Biochemistry | pmid:10504265 |
Imrie CW and McKay CJ | The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? | 1999 | Gastroenterol. Clin. North Am. | pmid:10503138 |
Sakaguchi T et al. | Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats. | 1999 | Hepatology | pmid:10498648 |
Marathe GK et al. | Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. | 1999 | J. Biol. Chem. | pmid:10497200 |
Mitidieri F and de Meis L | Ca(2+) release and heat production by the endoplasmic reticulum Ca(2+)-ATPase of blood platelets. Effect of the platelet activating factor. | 1999 | J. Biol. Chem. | pmid:10497193 |
Dekkers PE et al. | Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. | 1999 | Infect. Immun. | pmid:10496934 |
GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |
Comellas A et al. | Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. | 1999 | J. Physiol. Biochem. | pmid:10494654 |
Blackstone MO | ICAM-1 in cerulein-induced pancreatitis. | 1999 | Gastroenterology | pmid:10490367 |
Triggiani M et al. | Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. | 1999 | Biochem. Pharmacol. | pmid:10487538 |
Piccolo MT et al. | Chemotactic mediator requirements in lung injury following skin burns in rats. | 1999 | Exp. Mol. Pathol. | pmid:10486240 |
Koyama N and Ogawa Y | Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. | 1999 | Eur. J. Pediatr. | pmid:10486094 |
Kültürsay N et al. | Platelet-activating factor concentrations in healthy and septic neonates. | 1999 | Eur. J. Pediatr. | pmid:10485307 |
Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |
Kapui Z et al. | Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. | 1999 | Arzneimittelforschung | pmid:10483515 |
Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
Foitzik T et al. | Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. | 1999 May-Jun | J. Gastrointest. Surg. | pmid:10481117 |
Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
Oku H and Ishiguro K | Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. | 1999 | Phytother Res | pmid:10479766 |
Baker KE and Curtis MJ | Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10470998 |
Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
Conroy DM and Sirois P | Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. | 1999 | Inflammation | pmid:10466580 |
Kaminski JJ et al. | Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. | 1999 | Bioorg. Med. Chem. | pmid:10465415 |
Hsueh W et al. | Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. | 1998 Jan-Feb | Pediatr. Dev. Pathol. | pmid:10463267 |
Zardini DM et al. | Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. | 1999 | Cell Calcium | pmid:10463102 |
Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
Downing SJ et al. | Effect of inflammatory mediators on the electrophysiology of the human oviduct. | 1999 | Biol. Reprod. | pmid:10456842 |
Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
Subbanagounder G et al. | Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | 1999 | Circ. Res. | pmid:10455059 |
Nikbakht-Sangari M et al. | Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. | 1999 | Immunol. Invest. | pmid:10454000 |
Dervenis C et al. | Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. | 1999 | Int. J. Pancreatol. | pmid:10453421 |
Sakaguchi T et al. | Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. | 1999 | J. Surg. Res. | pmid:10452877 |
Partrick DA et al. | Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. | 1999 | J. Surg. Res. | pmid:10452867 |
Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
Wang H et al. | Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. | 1999 | Immunology | pmid:10447766 |
Alvi SA et al. | The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. | 1999 | Immunology | pmid:10447739 |
Davies D et al. | VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. | 1999 | Immunology | pmid:10447726 |