| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mollinedo F et al. | Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). | 1997 | Cancer Res. | pmid:9102220 |
| Denizot Y et al. | Presence and metabolism of lyso platelet-activating factor in human bone marrow. | 1997 | J Lipid Mediat Cell Signal | pmid:9101422 |
| Kudolo GB et al. | Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney. | 1997 | J Lipid Mediat Cell Signal | pmid:9101420 |
| Rocha FA et al. | PAF modulates eicosanoids and TNF release in immune-complex arthritis in rats. | 1997 | J Lipid Mediat Cell Signal | pmid:9101418 |
| Matsubara T et al. | Platelet-activating factor (PAF) and PAF acetylhydrolase activity in rat uterus and placenta during the late stages of pregnancy. | 1997 | Biol. Reprod. | pmid:9096869 |
| Byrum RS et al. | Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. | 1997 | J. Exp. Med. | pmid:9091580 |
| Yatsu T et al. | Renal effect of YM435, a new dopamine D1 receptor agonist, in anesthetized dogs. | 1997 | Eur. J. Pharmacol. | pmid:9088869 |
| Lin CC and Lin CY | Bronchoconstriction and eosinophil recruitment in guinea pig lungs after platelet activating factor administration. | 1997 | J Asthma | pmid:9088302 |
| Kurose I et al. | Oxidative stress during platelet-activating factor-induced microvascular dysfunction. | 1996 | Microcirculation | pmid:9086452 |
| Kume K et al. | [Study of platelet activating factor by using mouse ontogenic technology]. | 1996 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:9081720 |
| Mori TA et al. | Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081682 |
| Mineshita M et al. | Whole-blood incubation method to study neutrophil cytoskeletal dynamics. | 1997 | J. Immunol. Methods | pmid:9075772 |
| Tamura T et al. | Effects of platelet-activating factor on left ventricular performance in dogs. | 1997 | Jpn. Circ. J. | pmid:9070974 |
| Gomez R et al. | Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. | 1997 | Infect. Dis. Clin. North Am. | pmid:9067790 |
| Kagoshima M et al. | Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs. | 1997 | Pharmacology | pmid:9065955 |
| Wang H et al. | Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. | 1997 | Biochem. J. | pmid:9065783 |
| Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
| Odawara M et al. | Ginkgo biloba. | 1997 | Neurology | pmid:9065574 |
| Ishii I et al. | Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants. | 1997 | J. Biol. Chem. | pmid:9065450 |
| Becker BF et al. | [Interaction of adenosine with leukocytes and thrombocytes]. | 1996 | Z Kardiol | pmid:9064961 |
| Nick JA et al. | Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. | 1997 | J. Clin. Invest. | pmid:9062356 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | FEMS Immunol. Med. Microbiol. | pmid:9061358 |
| Lee YP et al. | Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation. | 1997 | Biochim. Biophys. Acta | pmid:9059515 |
| Bussolino F et al. | Role of soluble mediators in angiogenesis. | 1996 | Eur. J. Cancer | pmid:9059328 |
| Yousefi S et al. | Platelet-activating factor and the production of human interferon-gamma. | 1997 | J. Interferon Cytokine Res. | pmid:9058317 |
| Abu-Zidan FM et al. | Role of platelet-activating factor on cardiovascular dysfunction in postischemic shock in pigs. | 1997 | Eur Surg Res | pmid:9058081 |
| Anderson MR and Blumer JL | Advances in the therapy for sepsis in children. | 1997 | Pediatr. Clin. North Am. | pmid:9057790 |
| Clinical studies of IL-11, new platelet growth factor, presented. | 1997 | Oncology (Williston Park, N.Y.) | pmid:9057177 | |
| Collins LC and Roberts AM | Effects of platelet-activating factor on arteriolar and venular tone in rat trachea. | 1997 | Microvasc. Res. | pmid:9056476 |
| Forde RC and Fitzgerald DJ | Reactive oxygen species and platelet activation in reperfusion injury. | 1997 | Circulation | pmid:9054729 |
| Rodriguez-Barbero A et al. | Involvement of platelet-activating factor in gentamicin nephrotoxicity in rats. | 1997 Jan-Feb | Exp. Nephrol. | pmid:9052848 |
| Gruska S et al. | Prevalence of increased intracellular signal transduction in immortalized lymphoblasts from patients with essential hypertension and normotensive subjects. | 1997 | J. Hypertens. | pmid:9050967 |
| Lin CH et al. | The effect of the selective PAF antagonist CIS-19 on PAF- and antigen-induced bronchoconstriction, microvascular leakage and bronchial hyperreactivity in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050014 |
| Saitoh C et al. | Effect of YM934, a KATP channel opener, on airway hyperresponsiveness induced by platelet activating factor in guinea-pigs. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050013 |
| Chang TW | Improvement of survival from hemorrhagic shock by enterectomy in rats: finding to implicate the role of the gut for irreversibility of hemorrhagic shock. | 1997 | J Trauma | pmid:9042872 |
| Bonaccorsi L et al. | Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells. | 1997 | Biochim. Biophys. Acta | pmid:9042336 |
| Dohi T et al. | Stimulation of platelet-activating factor synthesis by neurotransmitters in salivary glands. | 1997 | J. Dent. Res. | pmid:9042079 |
| Feuerstein G et al. | Platelet-activating factor and cardiac diseases: therapeutic potential for PAF inhibitors. | 1997 | J Lipid Mediat Cell Signal | pmid:9041476 |
| Izzo AA and Benveniste J | Presence of paf-acether in human blood after thin-layer chromatography, but not after high-performance liquid chromatography purification. | 1996 | J Pharmacol Toxicol Methods | pmid:9040113 |
| Brzustowicz LM et al. | Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts. | 1997 | Hypertension | pmid:9039096 |
| Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
| Barden A et al. | Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. | 1997 | Clin. Sci. | pmid:9038589 |
| Le Gouill C et al. | Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor. | 1997 | FEBS Lett. | pmid:9037196 |
| Morozova NG et al. | [Synthesis of cationic alkylglucosides]. | 1996 Oct-Nov | Bioorg. Khim. | pmid:9036840 |
| Massicot F et al. | Preventive effects of two PAF-antagonists, PMS 536 and PMS 549, on cyclosporin-induced LLC-PK1 oxidative injury. | 1997 | J Lipid Mediat Cell Signal | pmid:9034965 |
| Heymans F et al. | Design and modeling of new platelet-activating factor antagonists. 3. Relative importance of hydrophobicity and electronic distribution in piperazinic series. | 1997 | J Lipid Mediat Cell Signal | pmid:9034962 |
| Tavet F et al. | Design and modeling of new platelet-activating factor antagonists. 2. Synthesis and biological activity of 1,4-bis-(3',4',5'-trimethoxybenzoyl)-2-alkyl and 2-alkyloxymethylpiperazines. | 1997 | J Lipid Mediat Cell Signal | pmid:9034961 |
| Binisti C et al. | Structure-activity relationships in platelet activating factor. 9. From PAF-antagonism to PLA2 inhibition. | 1997 | J Lipid Mediat Cell Signal | pmid:9034960 |
| Herbert JM et al. | Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat. | 1997 | J Lipid Mediat Cell Signal | pmid:9034959 |
| Yoshikawa T et al. | Role of superoxide and nitric oxide in platelet-activating factor-induced acute lung injury, hypotension, and mortality in rats. | 1997 | Crit. Care Med. | pmid:9034266 |