| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herbertson MJ et al. | Platelet-activating factor antagonism improves ventricular contractility in endotoxemia. | 1997 | Crit. Care Med. | pmid:9034254 |
| Hotter G et al. | Free radical enhancement promotes leucocyte recruitment through a PAF and LTB4 dependent mechanism. | 1997 | Free Radic. Biol. Med. | pmid:9034233 |
| Koenderman L | Priming of circulating human eosinophils following late response to allergen challenge. | 1997 | Eur. Respir. J. | pmid:9032524 |
| Karpouza AP and Vakirtzi-Lemonias C | The platelet-activating factor acetylhydrolase of mouse platelets. | 1997 | Biochim. Biophys. Acta | pmid:9030208 |
| Comminges C et al. | Studies on ether-phospholipids of vascular smooth muscle cells. Identification of a rapid Ca(2+)-dependent hydrolysis of alkyl-phosphatidylethanolamine promoted by endothelin-l. | 1997 | Biochim. Biophys. Acta | pmid:9030203 |
| Packham MA et al. | Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:9029375 |
| Bleivik B et al. | Protein kinase C inhibitors and PAF stimulate phosphatidylserine synthesis in human leucocytes. | 1996 | J Lipid Mediat Cell Signal | pmid:9029372 |
| Denizot Y et al. | PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. | 1996 | J Lipid Mediat Cell Signal | pmid:9029369 |
| He J et al. | Micellar electrokinetic capillary chromatographic analysis of platelet activating factor in human blood by indirect ultraviolet detection. | 1996 | Ann. Ist. Super. Sanita | pmid:9028060 |
| Vlasova II et al. | [Effect of a micellar preparation of polyunsaturated phosphatidylcholine on platelet aggregation in vitro]. | 1996 | Biull Eksp Biol Med | pmid:9026131 |
| Riera M et al. | Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023292 |
| Lee DR et al. | Induction of acrosome reaction in human spermatozoa accelerates the time of pronucleus formation of hamster oocytes after intracytoplasmic sperm injection. | 1997 | Fertil. Steril. | pmid:9022609 |
| Fukuda AI and Breuel KF | Effect of platelet activating factor on embryonic development and implantation in the mouse. | 1996 | Hum. Reprod. | pmid:9021383 |
| Bazan NG et al. | Bioactive lipids in excitatory neurotransmission and neuronal plasticity. | 1997 | Neurochem. Int. | pmid:9017670 |
| Ohmori T et al. | In vitro hypoxia of cortical and hippocampal CA1 neurons: glutamate, nitric oxide, and platelet activating factor participate in the mechanism of selective neural death in CA1 neurons. | 1996 | Brain Res. | pmid:9017237 |
| Carlson SA et al. | Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230. | 1996 | Recept Signal Transduct | pmid:9015866 |
| Maclennan KM et al. | Platelet-activating factor in the CNS. | 1996 | Prog. Neurobiol. | pmid:9015828 |
| Chakrabarti R et al. | Alteration of platelet-activating factor-induced signal transduction in macrophages by n-3 fatty acids. | 1997 | Cell. Immunol. | pmid:9015191 |
| Camussi G et al. | Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages. | 1997 | J. Immunol. | pmid:9013973 |
| Ishii S et al. | Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. | 1997 | EMBO J. | pmid:9009274 |
| Ohyama T et al. | Sensitive densitometry for the determination of platelet-activating factor and other phospholipids in human tears. | 1996 | Analyst | pmid:9008409 |
| Souza-Fiho MV et al. | Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. | 1997 | Am. J. Pathol. | pmid:9006340 |
| Vavilova GL et al. | [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. | 1996 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9005660 |
| O'Neill C | Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro. | 1997 | Biol. Reprod. | pmid:9002654 |
| Dagenais P et al. | Augmented expression of platelet-activating factor receptor gene by TNF-alpha through transcriptional activation in human monocytes. | 1997 | J. Leukoc. Biol. | pmid:9000543 |
| Sugatani J et al. | High-density lipoprotein inhibits the synthesis of platelet-activating factor in human vascular endothelial cells. | 1996 | J Lipid Mediat Cell Signal | pmid:8998599 |
| Merlos M et al. | Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). | 1997 | J. Pharmacol. Exp. Ther. | pmid:8996188 |
| Misra UK et al. | Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. | 1997 | J. Biol. Chem. | pmid:8995289 |
| Tuomanen EI | Molecular and cellular mechanisms of pneumococcal meningitis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993350 |
| Laniyonu AA et al. | Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. | 1997 | Shock | pmid:8989836 |
| Ohtani N and Asano G | [Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8987363 |
| Ferreira MG and Fonteles MC | Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8987112 |
| de Boissieu D et al. | Effect of BN 50727 on pathological findings and tissue platelet activating factor levels during ileal ischemia in newborn piglets. | 1996 | J. Pediatr. Surg. | pmid:8986985 |
| Michibayashi T | [Vascular responsiveness of platelet activating factor--with special reference to its action in the presence of platelets]. | 1996 | J Smooth Muscle Res | pmid:8985919 |
| MonteseirÃn J et al. | Formation of lipids, peptides and cytokines. | 1996 Sep-Oct | Allergol Immunopathol (Madr) | pmid:8985477 |
| Ho YS et al. | Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. | 1997 | Nature | pmid:8985254 |
| Dentener MA et al. | Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. | 1997 | J. Infect. Dis. | pmid:8985203 |
| Williams FM | Neutrophils and myocardial reperfusion injury. | 1996 | Pharmacol. Ther. | pmid:8981567 |
| Anderson R et al. | Membrane-stabilizing, anti-inflammatory interactions of macrolides with human neutrophils. | 1996 | Inflammation | pmid:8979156 |
| Sugano M et al. | Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists. | 1996 | J. Med. Chem. | pmid:8978857 |
| Bkaily G et al. | Modulation of cardiac cell Ca2+ currents by PAF. | 1996 | Blood Press Suppl | pmid:8973773 |
| Terada N et al. | The effect of anti-VLA-4 monoclonal antibody on eosinophil accumulation and leukotriene production in nasal mucosa. | 1996 | Acta Otolaryngol. | pmid:8973726 |
| Tokumura A et al. | Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipids. | 1996 | Lipids | pmid:8972457 |
| Liu L et al. | Transmigration of human neutrophils across airway epithelial cell monolayers is preferentially in the physiologic basolateral-to-apical direction. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8969272 |
| West RR et al. | ZG-1494 alpha, a novel platelet-activating factor acetyltransferase inhibitor from Penicillium rubrum, isolation, structure elucidation andbiological activity. | 1996 | J. Antibiot. | pmid:8968388 |
| Despotis GJ et al. | Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. | 1996 | Anesthesiology | pmid:8968178 |
| Sagara H et al. | Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils. | 1996 | Clin. Exp. Allergy | pmid:8963871 |
| Roudebush WE et al. | Effect of platelet-activating factor (PAF) on preimplantation mouse B6D2F1/J embryo formation. | 1996 | Am. J. Reprod. Immunol. | pmid:8962660 |
| Minhas BS et al. | Platelet activating factor and conception. | 1996 | Am. J. Reprod. Immunol. | pmid:8962659 |
| Izzo AA | PAF and the digestive tract. A review. | 1996 | J. Pharm. Pharmacol. | pmid:8961155 |