| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
| Ramesha CS and Pickett WC | Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid. | 1986 | J. Biol. Chem. | pmid:3011789 |
| Hellewell PG and Williams TJ | A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. | 1986 | J. Immunol. | pmid:2940300 |
| Touvay C et al. | Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. | 1986 | Immunopharmacology | pmid:3021651 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Silva PM et al. | Platelet involvement in rat paw edema induced by 2-methoxy-PAF. | 1986 | Inflammation | pmid:3793206 |
| Wu MS et al. | Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3795043 |
| Tetta C et al. | Platelet-activating factor contracts human myometrium in vitro. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3797421 |
| Montrucchio G et al. | In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. | 1986 | Prostaglandins | pmid:3797692 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Zimmerman GA and Klein-Knoeckel D | Human endothelial cells inhibit granulocyte aggregation in vitro. | 1986 | J. Immunol. | pmid:3009611 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Orozco C et al. | Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. | 1986 | J. Reprod. Fertil. | pmid:3806515 |
| Wissner A et al. | Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. | 1986 | J. Med. Chem. | pmid:3806583 |
| Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
| Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
| Fechter M et al. | Experimental eosinophilia and inflammation--the effect of various inflammatory mediators and chemoattractants. | 1986 | Exp Pathol | pmid:3013671 |
| Fisher RA et al. | Effects of beta-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | J. Biol. Chem. | pmid:3013865 |
| Darius H et al. | Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3015804 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| Coëffier E et al. | Transient activation of the acetyltransferase necessary for paf-acether biosynthesis in thrombin-activated platelets. | 1986 | Br. J. Haematol. | pmid:3964558 |
| Blank ML et al. | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3707974 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| Tarayre JP et al. | Exudative, cellular and humoral reactions to platelet-activating factor (PAF-acether) in the pleural cavity of rats. | 1986 | Eur. J. Pharmacol. | pmid:3755401 |
| Kikawa Y et al. | Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. | 1986 | Pediatr. Res. | pmid:3012451 |
| Bussolino F et al. | Production of platelet-activating factor by chick retina. | 1986 | J. Biol. Chem. | pmid:3023352 |
| Kester M et al. | Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. | 1986 | Biochim. Biophys. Acta | pmid:3019423 |
| Voelkel NF et al. | PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. | 1986 | Prostaglandins | pmid:3024235 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |
| Maes L et al. | Endogenic PAF-acether production by guinea pig endothelial cells in experimental arterial thrombosis. | 1986 | Pharmacol Res Commun | pmid:3774852 |
| Handley DA et al. | Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. | 1986 | Thromb. Haemost. | pmid:3775689 |
| Hwang SB and Lam MH | Species difference in the specific receptors of platelet activating factor. | 1986 | Biochem. Pharmacol. | pmid:3024653 |
| Han GQ et al. | [Neolignans from Piper hancei Maxim]. | 1986 | Yao Xue Xue Bao | pmid:3776545 |
| Koltai M et al. | Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3780855 |
| Montrucchio G et al. | Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. | 1986 | Int J Tissue React | pmid:3025124 |
| Salari H | Solid-phase extraction and reversed-phase high-performance liquid chromatographic technique for isolation and estimation of platelet activating factor in plasma. | 1986 | J. Chromatogr. | pmid:3782417 |
| Ng DS and Wong K | GTP regulation of platelet-activating factor binding to human neutrophil membranes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026378 |