Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Steel HC et al. Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. 2008 Chem Biol Drug Des pmid:18924285
Shibamoto T et al. PAF, rather than histamine, participates in mouse anaphylactic hypotension. 2008 Pharmacology pmid:18583921
Penna C et al. The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. 2008 J. Physiol. Pharmacol. pmid:18441387
Bang UC et al. Pharmacological approach to acute pancreatitis. 2008 World J. Gastroenterol. pmid:18494044
Zheng HL et al. [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. 2008 Sheng Li Xue Bao pmid:18425318
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Ogura M et al. Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. 2008 Auris Nasus Larynx pmid:17997066
Zheng M et al. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. 2008 Bioorg. Med. Chem. pmid:18835178
Rastogi P et al. Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18790994
Belayev L et al. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. 2008 Exp. Neurol. pmid:18793637
Li J et al. PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. 2008 Cell. Mol. Neurobiol. pmid:17712622
Chu W et al. Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. 2008 Phytother Res pmid:17724771
Kasperska-Zajac A et al. Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy. 2008 Recent Pat Inflamm Allergy Drug Discov pmid:19075994
XUE M et al. Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. 2008 Chin J Integr Med pmid:19082798
Kudriavtseva IuA et al. [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. 2008 Angiol Sosud Khir pmid:19156039
Galli SJ and Franco CB Basophils are back! 2008 Immunity pmid:18400194
Levy JH Platelet-activating factor, PAF acetylhydrolase, and anaphylaxis. 2008 N. Engl. J. Med. pmid:18385504
Ibe BO et al. Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. 2008 Int. Arch. Allergy Immunol. pmid:18362475
Tiemann U The role of platelet-activating factor in the mammalian female reproductive tract. 2008 Reprod. Domest. Anim. pmid:18363604
Ibe BO et al. Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases. 2008 Cell Prolif. pmid:18336468
Burks AW Peanut allergy. 2008 Lancet pmid:18456104
Huang GD et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. 2008 Chin J Integr Med pmid:18568325
Egea L et al. Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis. 2008 Biochim. Biophys. Acta pmid:18442488
Tsoukatos DC et al. Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery. 2008 J. Lipid Res. pmid:18587071
LeBlanc CJ et al. Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. 2008 Am. J. Vet. Res. pmid:18380580
Landgraf RG et al. Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17923399
Vadnais ML et al. Current concepts of molecular events during bovine and porcine spermatozoa capacitation. 2007 May-Jun Arch. Androl. pmid:17612869
Rosenwasser L New insights into the pathophysiology of allergic rhinitis. 2007 Jan-Feb Allergy Asthma Proc pmid:17390750
Hattermann K et al. The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. 2007 FASEB J. pmid:17264163
Boetkjaer A et al. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. 2007 Neurosci. Lett. pmid:17881124
Xu W et al. Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. 2007 Chin. Med. J. pmid:18028783
De Vriese C et al. Ghrelin interacts with human plasma lipoproteins. 2007 Endocrinology pmid:17289852
Doublier S et al. The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. 2007 Clin. Cancer Res. pmid:17908960
Shimada T et al. Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. 2007 J. Endocrinol. pmid:17911394
Whitehead SN et al. Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. 2007 Anal. Chem. pmid:17949058
Bixby CE et al. Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17951313
Liu WC et al. Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. 2007 Neurosci Bull pmid:17952135
Wu B et al. [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. 2007 Zhonghua Er Ke Za Zhi pmid:17953818
Owen JS et al. Platelet-activating factor. 2007 Meth. Enzymol. pmid:17954244
Ying-fang S et al. Effect of platelet-activating factor on cell proliferation & NF-kappaB activation in airway smooth muscle cells in rats. 2007 Indian J. Med. Res. pmid:17932440
Guerra CT et al. Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. 2007 Dig Liver Dis pmid:17936229
Kawano Y et al. The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). 2007 Am. J. Reprod. Immunol. pmid:17922696
Keam SJ and Plosker GL Rupatadine: a review of its use in the management of allergic disorders. 2007 Drugs pmid:17335300
Van Overloop H et al. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. 2007 Biol. Chem. pmid:17338639
Cui S et al. L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17395449
Roudebush WE Seminal platelet-activating factor. 2007 Semin. Thromb. Hemost. pmid:17253192
Ebihara S et al. A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. 2007 Inflamm. Res. pmid:17406808
Xia SH et al. Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. 2007 World J. Gastroenterol. pmid:17589953
Tosaki T et al. Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. 2007 Biol. Pharm. Bull. pmid:17268064
Zhang X et al. Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. 2007 Neurochem. Res. pmid:17268849
Sandford RM et al. The genetic basis of abdominal aortic aneurysms: a review. 2007 Eur J Vasc Endovasc Surg pmid:17276705
Slomiany BL and Slomiany A Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells. 2007 J. Physiol. Pharmacol. pmid:17440231
Ullrich SE Sunlight and skin cancer: lessons from the immune system. 2007 Mol. Carcinog. pmid:17443748
Richter M et al. Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17448648
Finnegan EM et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17483236
Cattaneo M et al. Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. 2007 Haematologica pmid:17488697
Kälvegren H et al. Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. 2007 Eur. J. Pharmacol. pmid:17459368
Taheri F and Bazan HE Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17460244
Dinubile MJ Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". 2007 Am. J. Physiol., Cell Physiol. pmid:17428843
Souza LJ et al. Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. 2007 Pancreatology pmid:17449968
Shin CR et al. Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. 2007 J. Periodont. Res. pmid:17451539
Truffinet V et al. No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. 2007 Leuk. Res. pmid:17350684
Paterson WG et al. Role of platelet-activating factor in acid-induced esophageal mucosal injury. 2007 Dig. Dis. Sci. pmid:17415649
Tsimikas S et al. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17626905
Li Y et al. Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. 2007 Biol. Reprod. pmid:17634444
Nagi-Miura N et al. Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. 2007 Biol. Pharm. Bull. pmid:17603181
Kooyman FN et al. Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. 2007 Infect. Immun. pmid:17606606
Dupré DJ et al. Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. 2007 Cell. Signal. pmid:17609120
Xavier RG et al. Enhanced platelet aggregation and activation under conditions of hypothermia. 2007 Thromb. Haemost. pmid:18064324
Dunkel B et al. Platelet activation in ponies with airway inflammation. 2007 Equine Vet. J. pmid:18065316
Wang J et al. Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. 2007 Int. J. Cardiol. pmid:16887214
Lu SM et al. The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. 2007 J Neuroimmune Pharmacol pmid:18040844
Rockel N et al. The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. 2007 J. Immunol. pmid:17785795
Tsantila N et al. Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. 2007 Mediators Inflamm. pmid:18253466
Takahashi T et al. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. 2007 Microvasc. Res. pmid:17027041
Shi W et al. [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18309677
Saluk-Juszczak J et al. The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. 2007 Curr. Microbiol. pmid:17160361
Huang YH et al. Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. 2007 J. Cell. Biochem. pmid:17131380
Osborn TM et al. Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. 2007 Am. J. Physiol., Cell Physiol. pmid:17135294
Huang GD et al. [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. 2007 Zhong Yao Cai pmid:18422199
Bathgate R et al. Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. 2007 Theriogenology pmid:17157372
Hammond A et al. Platelets in equine recurrent airway obstruction. 2007 Res. Vet. Sci. pmid:17107696
Vinores SA et al. TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. 2007 J. Neuroimmunol. pmid:17107717
Brkovic A and Sirois MG Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. 2007 J. Cell. Biochem. pmid:17115409
Choi JH et al. Impairment of p38 MAPK-mediated cytosolic phospholipase A2 activation in the kidneys is associated with pathogenicity of Candida albicans. 2007 Immunology pmid:17054728
El Behi M et al. Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. 2007 J. Neuroimmunol. pmid:17097744
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Shindou H et al. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. 2007 J. Biol. Chem. pmid:17182612
Ko HM et al. Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. 2007 Int. J. Cancer pmid:17187368
Bate C et al. Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. 2007 J Neuroinflammation pmid:17233902
Caini P et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. 2007 J. Viral Hepat. pmid:17212640
Callender HL et al. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. 2007 Anal. Chem. pmid:17194150
Heusler P and Boehmer G Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. 2007 Brain Res. pmid:17196945
Fragopoulou E et al. Biological activity of acetylated phenolic compounds. 2007 J. Agric. Food Chem. pmid:17199317
Greinacher A Too many hits in HIT? 2007 Am. J. Hematol. pmid:17729242
Gui C et al. Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. 2007 Proteins pmid:17243151
Park EJ et al. Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. 2007 Shock pmid:17510604
Young RE et al. Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. 2007 Br. J. Pharmacol. pmid:17471175
Steel HC et al. Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4. 2007 Clin. Exp. Immunol. pmid:17683509
Eckert RE and Jones SL Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. 2007 J. Leukoc. Biol. pmid:17684042