| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
| Xu W et al. | Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. | 2007 | Chin. Med. J. | pmid:18028783 |
| Keam SJ and Plosker GL | Rupatadine: a review of its use in the management of allergic disorders. | 2007 | Drugs | pmid:17335300 |
| Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
| Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
| Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
| Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
| Shin CR et al. | Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. | 2007 | J. Periodont. Res. | pmid:17451539 |
| Truffinet V et al. | No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. | 2007 | Leuk. Res. | pmid:17350684 |
| Paterson WG et al. | Role of platelet-activating factor in acid-induced esophageal mucosal injury. | 2007 | Dig. Dis. Sci. | pmid:17415649 |
| Tsimikas S et al. | New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17626905 |
| Li Y et al. | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. | 2007 | Biol. Reprod. | pmid:17634444 |
| Nagi-Miura N et al. | Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. | 2007 | Biol. Pharm. Bull. | pmid:17603181 |
| Kooyman FN et al. | Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. | 2007 | Infect. Immun. | pmid:17606606 |
| Dupré DJ et al. | Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. | 2007 | Cell. Signal. | pmid:17609120 |
| Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
| Wang J et al. | Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. | 2007 | Int. J. Cardiol. | pmid:16887214 |
| Tsantila N et al. | Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. | 2007 | Mediators Inflamm. | pmid:18253466 |
| Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
| Takahashi T et al. | Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. | 2007 | Microvasc. Res. | pmid:17027041 |
| Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
| Ko HM et al. | Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. | 2007 | Int. J. Cancer | pmid:17187368 |
| Bate C et al. | Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. | 2007 | J Neuroinflammation | pmid:17233902 |
| Caini P et al. | Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. | 2007 | J. Viral Hepat. | pmid:17212640 |
| Callender HL et al. | Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. | 2007 | Anal. Chem. | pmid:17194150 |
| Heusler P and Boehmer G | Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. | 2007 | Brain Res. | pmid:17196945 |
| Fragopoulou E et al. | Biological activity of acetylated phenolic compounds. | 2007 | J. Agric. Food Chem. | pmid:17199317 |
| Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
| Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
| Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
| Zhu T et al. | Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. | 2006 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:16902584 |
| Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
| Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
| Vasques E et al. | Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. | 2006 Jan-Feb | Endothelium | pmid:16885061 |
| Flamand N et al. | Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils. | 2006 | Br. J. Pharmacol. | pmid:16967052 |
| Zheng P et al. | Periodontal parameters and platelet-activating factor levels in serum and gingival crevicular fluid in a Chinese population. | 2006 | J. Clin. Periodontol. | pmid:16970624 |
| Tsoupras AB et al. | Isolation and identification of hydroxyl-platelet-activating factor from natural sources. | 2006 | Life Sci. | pmid:16860827 |
| Woo HY et al. | Mechanism for acute oral desensitization to antibiotics. | 2006 | Allergy | pmid:16867049 |
| Servillo L et al. | Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages. | 2006 | FASEB J. | pmid:16571775 |
| Flamand N et al. | Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. | 2006 | J. Leukoc. Biol. | pmid:16501051 |
| He J and Bazan HE | Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16505020 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Marchand C et al. | Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. | 2006 | J. Cell. Biochem. | pmid:16479592 |
| Buchanan MR | Biological basis and clinical implications of acetylsalicylic acid resistance. | 2006 | Can J Cardiol | pmid:16485051 |
| Heinrich S et al. | Evidence-based treatment of acute pancreatitis: a look at established paradigms. | 2006 | Ann. Surg. | pmid:16432347 |
| Ezoulin MJ et al. | Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | 2006 | Toxicol In Vitro | pmid:16472967 |
| Dianzani C et al. | Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. | 2006 | J. Pharm. Pharmacol. | pmid:16451750 |
| Gopichandran N and Leese HJ | The effect of paracrine/autocrine interactions on the in vitro culture of bovine preimplantation embryos. | 2006 | Reproduction | pmid:16452720 |
| Fischer A et al. | The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. | 2006 | Chembiochem | pmid:16453359 |
| Liu LR and Xia SH | Role of platelet-activating factor in the pathogenesis of acute pancreatitis. | 2006 | World J. Gastroenterol. | pmid:16489665 |
| Spitzer AL et al. | Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. | 2006 | Ann. Surg. | pmid:16495704 |
| Biancone L et al. | Platelet-activating factor synthesis and response on pancreatic islet endothelial cells: relevance for islet transplantation. | 2006 | Transplantation | pmid:16495796 |
| McMeekin SR et al. | E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. | 2006 | Blood | pmid:16514053 |
| Ramirez R et al. | Angiotensin II effect on hydraulic permeability: interaction with endothelin-1, nitric oxide, and platelet activating factor. | 2006 | J. Surg. Res. | pmid:16515797 |
| Matsumura Y et al. | A role for inflammatory mediators in the induction of immunoregulatory B cells. | 2006 | J. Immunol. | pmid:16982922 |
| Slomiany BL and Slomiany A | Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation interferes with salivary mucin synthesis via platelet activating factor generation. | 2006 | Inflammopharmacology | pmid:16983494 |
| Zhang Q et al. | Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. | 2006 | Exp. Dermatol. | pmid:16984258 |
| Hartvigsen K et al. | 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. | 2006 | Lipids | pmid:17069352 |
| Sugimoto S et al. | Purification and characterization of lysophospholipase D from rat brain. | 2006 | Biochim. Biophys. Acta | pmid:17071136 |
| Fallani A et al. | Platelet-activating factor (PAF) is the effector of IFN gamma-stimulated invasiveness and motility in a B16 melanoma line. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085325 |
| Slomiany BL and Slomiany A | Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction. | 2006 | Inflammopharmacology | pmid:17093905 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor. Part 13: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity. | 2006 | Bioorg. Med. Chem. | pmid:16893650 |
| Slomiany BL and Slomiany A | Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis. | 2006 | IUBMB Life | pmid:16754300 |
| Moreno SE et al. | Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. | 2006 | J. Immunol. | pmid:16818786 |
| Machado EM et al. | WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. | 2006 | J. Insect Physiol. | pmid:16777137 |
| Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
| Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
| Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
| Sneddon AA et al. | Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid. | 2006 | Biochim. Biophys. Acta | pmid:16829183 |
| Holder E et al. | Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation. | 2006 | Gene Ther. | pmid:16791284 |
| Kaneko MK et al. | Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. | 2006 | Gene | pmid:16766141 |
| De Plaen IG et al. | Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. | 2006 | Immunology | pmid:16771850 |
| Karabina SA and Ninio E | Plasma PAF-acetylhydrolase: an unfulfilled promise? | 2006 | Biochim. Biophys. Acta | pmid:16807087 |
| Cheng L et al. | Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16807360 |
| Fragopoulou E et al. | Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. | 2006 | J. Lab. Clin. Med. | pmid:16750665 |
| McLaughlin NJ et al. | Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. | 2006 | J. Immunol. | pmid:16709866 |
| Hsu HC et al. | Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16712790 |
| Mathonnet M et al. | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. | 2006 | World J. Gastroenterol. | pmid:16718768 |
| Cellai C et al. | Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | 2006 | Br. J. Cancer | pmid:16721373 |
| Goldring WP and Pattenden G | The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes. | 2006 | Acc. Chem. Res. | pmid:16700534 |
| Peng SY et al. | Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. | 2006 | Yao Xue Xue Bao | pmid:16671547 |
| Melnikova VO et al. | Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. | 2006 | J. Biol. Chem. | pmid:16306050 |
| Karagiorga G et al. | Biochemical parameters of bronchoalveolar lavage fluid in fat embolism. | 2006 | Intensive Care Med | pmid:16322975 |
| Faghiri Z and Bazan NG | Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16384990 |
| Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
| Poeckel D et al. | 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16174802 |
| Waschke J et al. | Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. | 2006 | Histochem. Cell Biol. | pmid:16195887 |
| Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
| Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |
| Gomes MT et al. | Platelet-activating factor-like activity isolated from Trypanosoma cruzi. | 2006 | Int. J. Parasitol. | pmid:16337632 |
| Karantonis HC et al. | Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation. | 2006 | Diabetes Res. Clin. Pract. | pmid:16236380 |
| Dohi T et al. | [Role of platelet-activating factor on spinal pain transduction]. | 2006 | Nippon Yakurigaku Zasshi | pmid:16508219 |
| Wu J et al. | Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. | 2006 | Biochem. J. | pmid:16255717 |
| Karidis NP et al. | Platelet-activating factor in liver injury: a relational scope. | 2006 | World J. Gastroenterol. | pmid:16773686 |
| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Ozturk H et al. | PAF antagonist BN-52021 reduces intercellular adhesion molecule-1 expression and oxidative stress in rats with reperfusion damage due to unilateral testicular torsion. | 2006 | Pediatr. Surg. Int. | pmid:16369775 |
| Judge A et al. | Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. | 2006 | Mol. Ther. | pmid:16275098 |