| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borgquist JD et al. | Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. | 2002 | J. Leukoc. Biol. | pmid:11994500 |
| Kalkanci A et al. | The role of tumour necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) interaction on murine candidosis. | 2002 | Mycoses | pmid:12000505 |
| McManus LM and Pinckard RN | PAF, a putative mediator of oral inflammation. | 2000 | Crit. Rev. Oral Biol. Med. | pmid:12002818 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| Zimmerman GA et al. | The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. | 2002 | Crit. Care Med. | pmid:12004251 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Zhang J et al. | Effect of buyang huanwu decoction on platelet activating factor content in arterial blood pre- and post-arterial thrombosis in rats. | 2001 | J Tradit Chin Med | pmid:12014136 |
| Ottino P et al. | Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. | 2002 | Exp. Eye Res. | pmid:12014920 |
| Michalis LK et al. | Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. | 2002 | Curr Med Res Opin | pmid:12017208 |
| Iatrou C et al. | Is platelet-activating factor produced during hemodialysis with AN-69 polyacrylonitrile membrane? | 2002 | Nephron | pmid:12021524 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Honda Z et al. | Platelet-activating factor receptor. | 2002 | J. Biochem. | pmid:12038971 |
| Lloberas N et al. | Postischemic renal oxidative stress induces inflammatory response through PAF and oxidized phospholipids. Prevention by antioxidant treatment. | 2002 | FASEB J. | pmid:12039876 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
| Kingston JK et al. | Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. | 2002 | Am. J. Vet. Res. | pmid:12061530 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
| Nakamura T et al. | Relationship between the platelet activating factor acetylhydrolase gene and intractability of ulcerative colitis. | 2002 | Dis. Colon Rectum | pmid:12068200 |
| Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
| Jaracz S et al. | Ginkgolides: selective acetylations, translactonization, and biological evaluation. | 2002 | J. Org. Chem. | pmid:12076171 |
| Downing SJ et al. | Effect of inflammatory mediators on the physiology of the human Fallopian tube. | 2002 | Hum Fertil (Camb) | pmid:12082208 |
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Mohr PJ and Halcomb RL | Convergent enantioselective synthesis of the tricyclic core of phomactin A. | 2002 | Org. Lett. | pmid:12098260 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. | 2002 | Brain Res. | pmid:12106666 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Parker MA et al. | Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | 2002 | J. Neurosci. Res. | pmid:12111814 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
| Sun Z et al. | Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. | 2002 | J. Surg. Res. | pmid:12121711 |
| Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
| Giorgi G et al. | Mass spectrometric characterization of substituted 2-thiazolin-4-one derivatives. | 2002 | J Mass Spectrom | pmid:12125004 |
| Benveniste J et al. | [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. | 1979 | C. R. Acad. Sci., D, Sci. Nat. | pmid:121258 |
| Kulikov VI and Muzya GI | Influence of platelet-activating factor, its cell analogs, and antagonist on the production of superoxide radicals by blood leukocytes of healthy and hypercholesterolemic individuals. | 2002 | Biochemistry Mosc. | pmid:12126473 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Teather LA et al. | Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures. | 2002 | Brain Res. | pmid:12133598 |
| Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
| Bazan NG et al. | What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. | 2002 | Prog. Brain Res. | pmid:12143339 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| De Plaen IG et al. | Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. | 2002 | Immunology | pmid:12153521 |
| Fonteh AN | Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. | 2002 | Eur. J. Biochem. | pmid:12153573 |
| Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
| Ryan KL et al. | Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12168504 |
| Takizawa T et al. | Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. | 2002 | J. Allergy Clin. Immunol. | pmid:12170264 |
| Sakai H et al. | Nitric oxide-induced Cl- secretion in isolated rat colon is mediated by the release of thromboxane A2. | 2002 | J. Physiol. (Lond.) | pmid:12181297 |
| Podolak-Dawidziak M | [Role of white cells and neoplastic cells in haemostasis]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12189915 |
| Strømgaard K et al. | Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. | 2002 | J. Med. Chem. | pmid:12190325 |
| Wong RK et al. | Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. | 2002 | Diabetes | pmid:12196480 |
| Goldring WP and Pattenden G | A total synthesis of phomactin A. | 2002 | Chem. Commun. (Camb.) | pmid:12196974 |
| Ewer AK | Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. | 2002 | Acta Paediatr Suppl | pmid:12200892 |
| Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
| Bazan H and Ottino P | The role of platelet-activating factor in the corneal response to injury. | 2002 | Prog Retin Eye Res | pmid:12207945 |
| Bussolati B et al. | Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. | 2002 | Int. J. Cancer | pmid:12209602 |
| Cadwallader KA et al. | Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. | 2002 | J. Immunol. | pmid:12218155 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Colwell JA et al. | Platelet adhesion and aggregation in diabetes mellitus. | 1979 | Metab. Clin. Exp. | pmid:122293 |
| Bussolati B et al. | Nitric oxide/platelet activating factor cross-talk in mesangial cells modulates the interaction with leukocytes. | 2002 | Kidney Int. | pmid:12234302 |
| Weyrich AS et al. | Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. | 2002 | Circulation | pmid:12234942 |
| Han SJ et al. | Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). | 2002 | J. Biol. Chem. | pmid:12235132 |
| Akai T et al. | Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. | 2002 | J. Neurooncol. | pmid:12241114 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Leung SW et al. | Platelet-activating factor enhanced the pressor response of endothelin-1. | 2002 | J. Cardiovasc. Pharmacol. | pmid:12352314 |
| Brewer C et al. | Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. | 2002 | J. Neurochem. | pmid:12354298 |
| Marin V et al. | Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. | 2002 | Eur. J. Immunol. | pmid:12355450 |
| Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356842 |
| Downing SJ et al. | Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? | 2002 | Reproduction | pmid:12361471 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| Michibayashi T | Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. | 2002 | Int Angiol | pmid:12384648 |
| Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Murohisa G et al. | Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. | 2002 | Liver | pmid:12390475 |
| Kato M et al. | Platelet-activating factor activates two distinct effector pathways in human eosinophils. | 2002 | J. Immunol. | pmid:12391244 |
| Ueno H et al. | Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. | 2002 | Crit. Care Med. | pmid:12394951 |
| Sibelius U et al. | Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. | 2002 | Crit. Care Med. | pmid:12394960 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Eikelboom JW et al. | Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. | 2002 | Eur. Heart J. | pmid:12419297 |
| Tanaka S and Koike T | Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. | 2002 | Glia | pmid:12420315 |
| Maniscalco M et al. | Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. | 2002 | Eur. J. Clin. Invest. | pmid:12423328 |
| Hsueh W et al. | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. | 2003 Jan-Feb | Pediatr. Dev. Pathol. | pmid:12424605 |
| Dun Y et al. | Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12428428 |
| Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
| Gélinas DS et al. | Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. | 2002 | Br. J. Pharmacol. | pmid:12429574 |
| Mahmoud FF et al. | In vitro effects of ginkgolide B combined with cyclosporin A on T-lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects. | 2002 | Transplant. Proc. | pmid:12431672 |
| Arai H | Platelet-activating factor acetylhydrolase. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432911 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Lee YM et al. | Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. | 2002 | J. Lab. Clin. Med. | pmid:12434132 |
| Abu-Zidan FM and Windsor JA | Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. | 2002 | Eur J Surg | pmid:12440758 |
| Pawliczak R et al. | Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12444032 |
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Marrache AM et al. | Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. | 2002 | J. Immunol. | pmid:12444157 |
| Pacheco P et al. | Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. | 2002 | J. Immunol. | pmid:12444160 |