| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Y et al. | Homosecoiridoids from the flower buds of Lonicera japonica. | 2011 | J. Nat. Prod. | pmid:21942812 |
| Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
| Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
| Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
| Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
| Uriarte SM et al. | Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. | 2011 | J. Immunol. | pmid:21642540 |
| Frelinger AL et al. | Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. | 2011 | Thromb. Haemost. | pmid:21713327 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Semini G et al. | Impact of alkylphospholipids on the gene expression profile of HaCaT cells. | 2011 | Pharmacogenet. Genomics | pmid:21681147 |
| Khan BQ and Kemp SF | Pathophysiology of anaphylaxis. | 2011 | Curr Opin Allergy Clin Immunol | pmid:21659865 |
| Lacy P et al. | Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. | 2011 | Int. Arch. Allergy Immunol. | pmid:21576984 |
| Mushtaq N et al. | Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter. | 2011 | J. Allergy Clin. Immunol. | pmid:21247619 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Metz M and Maurer M | Rupatadine for the treatment of allergic rhinitis and urticaria. | 2011 | Expert Rev Clin Immunol | pmid:21162645 |
| Cureton EL et al. | Endothelin-1 attenuates increases in hydraulic conductivity due to platelet-activating factor via prostacyclin release. | 2011 | J. Appl. Physiol. | pmid:21183623 |
| Liu J et al. | Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. | 2011 | Circ. Res. | pmid:21183738 |
| Ha SW and Lee CS | Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation. | 2010 May-Jun | Neurochem. Int. | pmid:20304020 |
| Michelotto PV et al. | Platelet-activating factor and evidence of oxidative stress in the bronchoalveolar fluid of Thoroughbred colts during race training. | 2010 Mar-Apr | J. Vet. Intern. Med. | pmid:20102491 |
| Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
| Ciprandi G and Cirillo I | Rupatadine improves nasal symptoms, airflow and inflammation in patients with persistent allergic rhinitis: a pilot study. | 2010 Apr-Jun | J. Biol. Regul. Homeost. Agents | pmid:20487631 |
| Kordan W et al. | Effect of platelet activating factor (PAF) supplementation in semen extender on viability and ATP content of cryopreserved canine spermatozoa. | 2010 | Pol J Vet Sci | pmid:21370733 |
| Garcia CC et al. | Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. | 2010 | PLoS Pathog. | pmid:21079759 |
| de Souza Carmo EV et al. | Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages. | 2010 | PLoS ONE | pmid:21082032 |
| Nandy D et al. | Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes. | 2010 | J. Cell. Mol. Med. | pmid:19754670 |
| Borthakur A et al. | Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent. | 2010 | Inflamm. Bowel Dis. | pmid:19714753 |
| Fité R and Borja J | Rupatadine and heart rhythm disturbances. | 2010 | Clin. Pharmacol. Ther. | pmid:19727070 |
| Donado E et al. | No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a 'thorough QT/QTc study' performed according to ICH guidelines. | 2010 | Br J Clin Pharmacol | pmid:20406224 |
| Saad MM et al. | Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. | 2010 | Can J Anaesth | pmid:19882198 |
| Chen H et al. | Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. | 2010 | Clin Oral Investig | pmid:19826843 |
| Sreevidya CS et al. | Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. | 2010 | J. Invest. Dermatol. | pmid:19829299 |
| Lautenschläger I et al. | A model of the isolated perfused rat small intestine. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19910525 |
| Yang Y et al. | Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase. | 2010 | Eur. Respir. J. | pmid:19926744 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Coppo R et al. | Aberrantly glycosylated IgA1 induces mesangial cells to produce platelet-activating factor that mediates nephrin loss in cultured podocytes. | 2010 | Kidney Int. | pmid:20016469 |
| Xu Z et al. | Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor. | 2010 | Mol. Ther. | pmid:19953082 |
| Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
| Wang L et al. | Three new compounds from Morus nigra L. | 2010 | J Asian Nat Prod Res | pmid:20552479 |
| Lu J et al. | Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. | 2010 | Pediatr. Res. | pmid:20531249 |
| Kim DD et al. | Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo. | 2010 | Microcirculation | pmid:20163539 |
| Yost CC et al. | The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. | 2010 | Biochimie | pmid:20167241 |
| Sharif NA and Wiernas TK | Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells. | 2010 | J Ocul Pharmacol Ther | pmid:20187806 |
| Metz M et al. | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. | 2010 | Ann. Allergy Asthma Immunol. | pmid:20143651 |
| Xiping Z et al. | Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis. | 2010 | Inflammation | pmid:20127399 |
| Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
| Moriguchi S et al. | Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. | 2010 | Neuroscience | pmid:20074623 |
| Zhou X and He P | Endothelial [Ca2+]i and caveolin-1 antagonistically regulate eNOS activity and microvessel permeability in rat venules. | 2010 | Cardiovasc. Res. | pmid:20080986 |
| Grassi G et al. | Exogenous platelet-activating factor improves the motility of human spermatozoa evaluated with C.A.S.A.: optimal concentration and incubation time. | 2010 | J. Endocrinol. Invest. | pmid:20220291 |
| Binder U et al. | The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans. | 2010 | Mol. Microbiol. | pmid:19889092 |
| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
| Peng SY et al. | [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. | 2010 | Yao Xue Xue Bao | pmid:21351565 |