| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Folch E et al. | H(2)O(2) and PARS mediate lung P-selectin upregulation in acute pancreatitis. | 2000 | Free Radic. Biol. Med. | pmid:10889459 |
| Bailey SR et al. | Differential activation of platelets from normal and allergic ponies by PAF and ADP. | 2000 | Inflamm. Res. | pmid:10893045 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
| Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
| Hu L et al. | Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity. | 2000 | Bioorg. Med. Chem. | pmid:10896127 |
| Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
| Clark GD et al. | Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. | 2000 | Neurochem. Res. | pmid:10905621 |
| Wang JH and Sun GY | Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). | 2000 | Neurochem. Res. | pmid:10905622 |
| Baker RR | Lipid acetylation reactions and the metabolism of platelet-activating factor. | 2000 | Neurochem. Res. | pmid:10905630 |
| Francescangeli E et al. | Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. | 2000 | Neurochem. Res. | pmid:10905633 |
| Parrish PR and Larson DF | Pharmacological effect of nitroprusside on platelet aggregation. | 1999 | J Extra Corpor Technol | pmid:10915472 |
| Unno N et al. | Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan. | 2000 | J. Vasc. Surg. | pmid:10917985 |
| Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |
| Choi JH et al. | Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB. | 2000 | Inflammation | pmid:10921504 |
| Smalley DM et al. | The local effect of PAF on leukocyte adherence to small bowel mesenteric venules following intra-abdominal contamination. | 2000 | Inflammation | pmid:10921505 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin, two antifibrinolytic drugs, on PAF-induced plasma extravasation in unanesthetized rats. | 2000 | Inflammation | pmid:10921506 |
| Klyubin IV et al. | The role of reactive oxygen species in membrane potential changes in macrophages and astrocytes. | 2000 | Membr Cell Biol | pmid:10926373 |
| Roudebush WE and Purnell ET | Platelet-activating factor content in human spermatozoa and pregnancy outcome. | 2000 | Fertil. Steril. | pmid:10927041 |
| Matsunaga Y et al. | Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction. | 2000 | Br. J. Pharmacol. | pmid:10928955 |
| Capasso R et al. | Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. | 2000 | Fitoterapia | pmid:10930724 |
| Henig NR et al. | Effect of recombinant human platelet-activating factor-acetylhydrolase on allergen-induced asthmatic responses. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10934081 |
| Haribabu B et al. | Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. | 2000 | J. Exp. Med. | pmid:10934231 |
| Miyatake T et al. | Analysis of cardiac function during hyperacute rejection: effects of PAF antagonist, TXA(2) inhibitor/antagonists, and nitroglycerin. | 2000 | Transplant. Proc. | pmid:10936319 |
| Raible DG et al. | Hydrogen peroxide release from human eosinophils on fibronectin: scopoletin enhances eosinophil activation. | 2000 | Free Radic. Biol. Med. | pmid:10938462 |
| Baskova I et al. | Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. | 2000 | Platelets | pmid:10938885 |
| Pávó I et al. | Interactions of pro-inflammatory and vasoactive mediators with nitric oxide in the regulation of rat vascular permeability during laparotomy. | 2000 | Eur. J. Pharmacol. | pmid:10940373 |
| Balestrieri ML and Lee T | Regulation of the biosynthesis of acyl analogs of platelet-activating factor by purinergic agonist in endothlial cells. | 2000 | FEBS Lett. | pmid:10940389 |
| Porta C et al. | Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. | 2000 | Haematologica | pmid:10942928 |
| Miyao Y et al. | Role of cytokines and adhesion molecules in ischemia and reperfusion in patients with acute myocardial infarction. | 1999 | Jpn. Circ. J. | pmid:10943615 |
| Kobayashi Y et al. | [Inhibitory effect of suplatast tosilate on eosinophil migration]. | 2000 | Arerugi | pmid:10944827 |
| Liu JK et al. | Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10945272 |
| Ueda T et al. | Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. | 2000 | J. Surg. Res. | pmid:10945960 |
| Marathe GK et al. | Bioactive phospholipid oxidation products. | 2000 | Free Radic. Biol. Med. | pmid:10946218 |
| Zhuang Q et al. | Activation via multiple signaling pathways induces down-regulation of platelet-activating factor receptors on human B lymphocytes. | 2000 | J. Immunol. | pmid:10946267 |
| Davenpeck KL et al. | Activation of human leukocytes reduces surface P-selectin glycoprotein ligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. | 2000 | J. Immunol. | pmid:10946308 |
| Martin M et al. | [Antiretroviral ant anti-inflammatory properties of a novel platelet activation factor antagonist, PMS-601]. | 2000 | Pathol. Biol. | pmid:10949851 |
| Countryman NB et al. | Evidence for involvement of the epidermal platelet-activating factor receptor in ultraviolet-B-radiation-induced interleukin-8 production. | 2000 | J. Invest. Dermatol. | pmid:10951245 |
| Soeki T et al. | Plasma and platelet plasminogen activator inhibitor-1 in patients with acute myocardial infarction. | 2000 | Jpn. Circ. J. | pmid:10952148 |
| Gálvez J et al. | Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. | 2000 | Br. J. Pharmacol. | pmid:10952687 |
| Maniscalco M et al. | The effect of platelet-activating factor (PAF) on nasal airway resistance in healthy subjects is not mediated by nitric oxide. | 2000 | Allergy | pmid:10955702 |
| Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
| Jeon SY et al. | Ultrastructural changes in platelet activating factor-induced epithelial damage in rabbit maxillary sinus mucosa. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10961804 |
| Toró A et al. | Transannular Diels-Alder studies on the asymmetric total synthesis of chatancin: the pyranophane approach. | 2000 | Org. Lett. | pmid:10964353 |
| Durán WN et al. | Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. | 2000 | Microvasc. Res. | pmid:10964584 |
| Wereszczynska-Siemiatkowska U et al. | Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect. | 2000 | Exp. Toxicol. Pathol. | pmid:10965985 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Taguchi R et al. | Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. | 2000 | J Mass Spectrom | pmid:10972995 |
| Saito S et al. | Modulatory roles of RANTES in IL-4 production by human blood CD4(+)T cells. | 2000 | Cytokine | pmid:10975998 |
| Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |