| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagase T et al. | Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9372685 |
| Snyder F | CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. | 1997 | Biochim. Biophys. Acta | pmid:9370322 |
| Saeed SA et al. | Anti-thrombotic and anti-inflammatory activities of protopine. | 1997 | Pharmacol. Res. | pmid:9368908 |
| Manna SK et al. | Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. | 1997 | J. Immunol. | pmid:9366432 |
| Kishimoto S et al. | Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363928 |
| Hershkowitz M and Adunsky A | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. | 1996 Nov-Dec | Neurobiol. Aging | pmid:9363797 |
| Radonjic-Lazovic G and Roudebush WE | The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. | 1995 | Early Pregnancy | pmid:9363251 |
| May JA et al. | Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. | 1997 | Thromb. Res. | pmid:9361371 |
| Wang H et al. | Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. | 1997 | Pediatr. Res. | pmid:9357930 |
| Silomon M et al. | Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. | 1997 | J. Surg. Res. | pmid:9356229 |
| Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
| Nagaoka H et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). | 1997 | Chem. Pharm. Bull. | pmid:9353894 |
| Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |
| Denham W et al. | Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. | 1997 | Gastroenterology | pmid:9352880 |
| Bzeizi KI et al. | Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. | 1997 | Liver Transpl Surg | pmid:9346727 |
| Aspey BS et al. | Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. | 1997 | Metab Brain Dis | pmid:9346472 |
| Million M et al. | Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. | 1997 | Eur. J. Pharmacol. | pmid:9346330 |
| Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
| Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
| Rezaul K et al. | Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345263 |
| Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
| Francescangeli E et al. | Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. | 1997 | Neurochem. Res. | pmid:9342735 |
| Hirashima Y et al. | Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. | 1997 | Neurochem. Res. | pmid:9342729 |
| Ohashi Y et al. | Platelet activating factor compromises airway epithelial defense functions. | 1997 | J. Allergy Clin. Immunol. | pmid:9338547 |
| Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
| Getting SJ et al. | Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336316 |
| Knight D et al. | Adenosine A3 receptor stimulation inhibits migration of human eosinophils. | 1997 | J. Leukoc. Biol. | pmid:9335316 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
| Weber C and Springer TA | Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. | 1997 | J. Clin. Invest. | pmid:9329974 |
| DeLano FA et al. | Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade. | 1997 | Microcirculation | pmid:9329011 |
| Murray J et al. | Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. | 1997 | Blood | pmid:9326245 |
| Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
| Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
| Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
| Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
| Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
| Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
| Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
| Wan S et al. | Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. | 1997 | Chest | pmid:9315800 |
| Cepinskas G et al. | Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement. | 1997 | Circ. Res. | pmid:9314844 |
| Teixeira MM et al. | Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. | 1997 | J. Clin. Invest. | pmid:9312163 |
| Cortijo J et al. | Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro. | 1997 | Eur. J. Pharmacol. | pmid:9311663 |
| Tailor A et al. | Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. | 1997 | J. Leukoc. Biol. | pmid:9307068 |
| Oh-ishi S | [Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9306414 |
| Ablett JM et al. | Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. | 1997 | Equine Vet. J. | pmid:9306066 |
| Balsa D et al. | Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. | 1997 | J Lipid Mediat Cell Signal | pmid:9302653 |
| Bialasiewicz P et al. | Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients. | 1997 | J Lipid Mediat Cell Signal | pmid:9302652 |
| Herbert JM et al. | Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. | 1997 | J Lipid Mediat Cell Signal | pmid:9302650 |
| Kimura M et al. | Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9301630 |
| Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |