| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Pancreatitis | D010195 | 10 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Rhinitis | D012220 | 10 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Asphyxia Neonatorum | D001238 | 4 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abu-Zidan FM et al. | Role of platelet-activating factor on cardiovascular dysfunction in postischemic shock in pigs. | 1997 | Eur Surg Res | pmid:9058081 |
| Yousefi S et al. | Platelet-activating factor and the production of human interferon-gamma. | 1997 | J. Interferon Cytokine Res. | pmid:9058317 |
| Bussolino F et al. | Role of soluble mediators in angiogenesis. | 1996 | Eur. J. Cancer | pmid:9059328 |
| Lee YP et al. | Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation. | 1997 | Biochim. Biophys. Acta | pmid:9059515 |
| Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | FEMS Immunol. Med. Microbiol. | pmid:9061358 |
| Nick JA et al. | Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. | 1997 | J. Clin. Invest. | pmid:9062356 |
| Becker BF et al. | [Interaction of adenosine with leukocytes and thrombocytes]. | 1996 | Z Kardiol | pmid:9064961 |
| Ishii I et al. | Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants. | 1997 | J. Biol. Chem. | pmid:9065450 |
| Odawara M et al. | Ginkgo biloba. | 1997 | Neurology | pmid:9065574 |
| Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
| Wang H et al. | Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. | 1997 | Biochem. J. | pmid:9065783 |
| Kagoshima M et al. | Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs. | 1997 | Pharmacology | pmid:9065955 |
| Gomez R et al. | Pathogenesis of preterm labor and preterm premature rupture of membranes associated with intraamniotic infection. | 1997 | Infect. Dis. Clin. North Am. | pmid:9067790 |
| Tamura T et al. | Effects of platelet-activating factor on left ventricular performance in dogs. | 1997 | Jpn. Circ. J. | pmid:9070974 |
| Mineshita M et al. | Whole-blood incubation method to study neutrophil cytoskeletal dynamics. | 1997 | J. Immunol. Methods | pmid:9075772 |
| Mori TA et al. | Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9081682 |
| Kume K et al. | [Study of platelet activating factor by using mouse ontogenic technology]. | 1996 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:9081720 |
| Kurose I et al. | Oxidative stress during platelet-activating factor-induced microvascular dysfunction. | 1996 | Microcirculation | pmid:9086452 |
| Lin CC and Lin CY | Bronchoconstriction and eosinophil recruitment in guinea pig lungs after platelet activating factor administration. | 1997 | J Asthma | pmid:9088302 |
| Yatsu T et al. | Renal effect of YM435, a new dopamine D1 receptor agonist, in anesthetized dogs. | 1997 | Eur. J. Pharmacol. | pmid:9088869 |
| Byrum RS et al. | Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. | 1997 | J. Exp. Med. | pmid:9091580 |
| Matsubara T et al. | Platelet-activating factor (PAF) and PAF acetylhydrolase activity in rat uterus and placenta during the late stages of pregnancy. | 1997 | Biol. Reprod. | pmid:9096869 |
| Rocha FA et al. | PAF modulates eicosanoids and TNF release in immune-complex arthritis in rats. | 1997 | J Lipid Mediat Cell Signal | pmid:9101418 |
| Kudolo GB et al. | Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney. | 1997 | J Lipid Mediat Cell Signal | pmid:9101420 |
| Denizot Y et al. | Presence and metabolism of lyso platelet-activating factor in human bone marrow. | 1997 | J Lipid Mediat Cell Signal | pmid:9101422 |
| Mollinedo F et al. | Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). | 1997 | Cancer Res. | pmid:9102220 |
| Toledano BJ et al. | Platelet-activating factor abrogates apoptosis induced by cross-linking of the surface IgM receptor in a human B lymphoblastoid cell line. | 1997 | J. Immunol. | pmid:9103434 |
| Norman KE et al. | Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505. | 1997 | Br. J. Pharmacol. | pmid:9105704 |
| Takano H et al. | Effects of aminoguanidine on systemic inflammatory response syndrome induced by platelet activating factor and by lipopolysaccharide in rats. | 1997 | Eur. J. Pharmacol. | pmid:9105885 |
| Silverstein FS et al. | Cytokines and perinatal brain injury. | 1997 Apr-May | Neurochem. Int. | pmid:9106251 |
| Baker RR and Chang HY | Neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor are located in the nuclear envelope and show differential losses in activity. | 1997 | Biochim. Biophys. Acta | pmid:9106499 |
| Konstantinov SM et al. | Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. | 1997 | Acta Trop. | pmid:9107362 |
| Guerrant RL et al. | Diarrhea, demography and cell signaling: lessons from microbial toxins. | 1997 | Trans. Am. Clin. Climatol. Assoc. | pmid:9108674 |
| Thielman NM et al. | Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. | 1997 | J. Clin. Invest. | pmid:9109445 |
| Nishiwaki H et al. | Prednisolone, platelet-activating factor receptor antagonist, or superoxide dismutase reduced leukocyte entrapment induced by interferon alpha in retinal microcirculation. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9112975 |
| Gentry PA et al. | An inherited platelet function defect in a Simmental crossbred herd. | 1997 | Can. J. Vet. Res. | pmid:9114964 |
| Ali H et al. | Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. | 1997 | J. Biol. Chem. | pmid:9115222 |
| Nauck M et al. | Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115750 |
| Okada S et al. | Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet-activating factor and eosinophil-active cytokines. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115757 |
| Greaves MW and Judge MR | Platelet activating factor in psoriasis. | 1997 | Br. J. Dermatol. | pmid:9115938 |
| Muguruma K and Johnston JM | Metabolism of platelet-activating factor in rat epididymal spermatozoa. | 1997 | Biol. Reprod. | pmid:9116157 |
| Le Solleu H et al. | Determination of a PAF antagonist pharmacophore using combined Molecular Electrostatic Potential and Molecular Lipophilicity Potential. | 1994 | Drug Des Discov | pmid:9116169 |
| Miao FJ et al. | Contribution of adrenal hormones to nicotine-induced inhibition of synovial plasma extravasation in the rat. | 1997 | Br. J. Pharmacol. | pmid:9117123 |
| Im SY et al. | A protective role of platelet-activating factor in murine candidiasis. | 1997 | Infect. Immun. | pmid:9119469 |
| Milella M et al. | CD16 cross-linking induces both secretory and extracellular signal-regulated kinase (ERK)-dependent cytosolic phospholipase A2 (PLA2) activity in human natural killer cells: involvement of ERK, but not PLA2, in CD16-triggered granule exocytosis. | 1997 | J. Immunol. | pmid:9120268 |
| Xia D and Samols D | Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9122237 |
| Keskinoglu A et al. | Inflammatory lipid mediators and immunologic recognition in allogeneic renal transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9122948 |
| Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
| Teixeira MM and Hellewell PG | Evidence that the eosinophil is a cellular target for the inhibitory action of salmeterol on eosinophil recruitment in vivo. | 1997 | Eur. J. Pharmacol. | pmid:9128847 |
| He CF et al. | Postural vasoregulation and mediators of reperfusion injury in venous ulceration. | 1997 | J. Vasc. Surg. | pmid:9129619 |
| Isogai E et al. | Role of platelet-activating-factor (PAF) on cellular responses after stimulation with leptospire lipopolysaccharide. | 1997 | Microbiol. Immunol. | pmid:9130240 |
| Hanahan DJ | The continuing biochemical challenge of PAF and closely related lipid mediators. | 1996 | Adv. Exp. Med. Biol. | pmid:9131117 |
| Snyder F et al. | Biosynthesis of platelet-activating factor and enzyme inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131118 |
| Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
| Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
| Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
| Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
| van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
| Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
| Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
| Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
| Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
| Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
| Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
| Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
| Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
| Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Morooka S and Natsume Y | Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131147 |
| Sanchez Crespo M et al. | Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131148 |
| Saito K | PAF response to inflammatory and non-inflammatory stimuli. | 1996 | Adv. Exp. Med. Biol. | pmid:9131150 |
| Silver D et al. | Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131151 |
| Lopes-Martins RA et al. | Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. | 1996 | Adv. Exp. Med. Biol. | pmid:9131152 |
| Camussi G et al. | Platelet-activating factor and angiogenesis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131153 |
| Oh-Ishi S et al. | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131154 |
| Tetta C et al. | The role of platelet-activating factor in the biocompatibility of hemodialysis membranes. | 1996 | Adv. Exp. Med. Biol. | pmid:9131156 |
| O'Neill C | PAF promotes the development of the preimplantation embryo. | 1996 | Adv. Exp. Med. Biol. | pmid:9131158 |
| Ammit AJ and O'Neill C | PAF released by preimplantation embryos binds to albumin. | 1996 | Adv. Exp. Med. Biol. | pmid:9131159 |
| Narahara H et al. | Role of platelet-activating factor in parturition. | 1996 | Adv. Exp. Med. Biol. | pmid:9131160 |
| Ahmed A and Dearn S | The role of platelet-activating factor and its receptor in endometrial receptivity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131161 |
| Korth RM | Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131162 |
| Zimmerman GA et al. | Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. | 1996 | Adv. Exp. Med. Biol. | pmid:9131163 |
| Yang HC et al. | Characterization of plasmalogen-selective phospholipase A2 from bovine brain. | 1996 | Adv. Exp. Med. Biol. | pmid:9131165 |
| Ferby I et al. | PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. | 1996 | Adv. Exp. Med. Biol. | pmid:9131167 |
| Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
| Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
| McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
| Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
| Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
| Bazan HE and Varner L | A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet activating factor (PAF) in corneal epithelium. | 1997 | Curr. Eye Res. | pmid:9134327 |
| Nogami K et al. | Involvement of platelet-activating factor (PAF) in glutamate neurotoxicity in rat neuronal cultures. | 1997 | Brain Res. | pmid:9134961 |
| Bito H et al. | Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:9137600 |
| Caplan MS et al. | The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9138176 |
| Jones RE | Synthesis of ether lipids and phosphatidylethanolamine by ejaculated human spermatozoa. | 1997 May-Jun | Arch. Androl. | pmid:9140614 |
| Schurr MJ et al. | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1997 | Surgery | pmid:9142146 |
| Nakayama R et al. | Changes in PAF (platelet-activating factor) production during cell cycle of yeast Saccharomyces cerevisiae. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9145522 |
| Teixeira MM et al. | Characterization of the prostanoid receptors mediating inhibition of PAF-induced aggregation of guinea-pig eosinophils. | 1997 | Br. J. Pharmacol. | pmid:9146890 |